Compile Data Set for Download or QSAR
Found 170 with Last Name = 'hightower' and Initial = 'k'
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)copy SMILEScopy InChI
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human recombinant GST-6XHis-VEGFR2 by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296010(2-isobutyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of SGK1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03VCPubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296011(2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of SGK1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03VCPubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195878(1-(4-(4-amino-7-phenylfuro[3,2-c]pyridin-3-yl)phen...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant GST-Tie2 by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296009(2-ethyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of SGK1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03VCPubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195879(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195878(1-(4-(4-amino-7-phenylfuro[3,2-c]pyridin-3-yl)phen...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant GST-6XHis-VEGFR2 by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296003(4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic ...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of SGK1 by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296015(2-(4-(5-(3-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of SGK1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03VCPubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195888(2-(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,...)copy SMILEScopy InChI
Affinity DataIC50: 44nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195878(1-(4-(4-amino-7-phenylfuro[3,2-c]pyridin-3-yl)phen...)copy SMILEScopy InChI
Affinity DataIC50: 46nMAssay Description:Inhibition of human recombinant GST-Tie2 by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296014(2-methyl-2-(4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of SGK1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03VCPubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195877(3-(3-chloro-4-fluorophenyl)-7-(pyridin-3-yl)thieno...)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195892(3-(3-chloro-4-fluorophenyl)-7-(3-(methylsulfonyl)p...)copy SMILEScopy InChI
Affinity DataIC50: 59nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296013(2-methyl-2-(4-(5-(naphthalen-2-yl)-1H-pyrrolo[2,3-...)copy SMILEScopy InChI
Affinity DataIC50: 63nMAssay Description:Inhibition of SGK1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03VCPubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296004(2-(4-(5-(naphthalen-2-yl)-1H-pyrrolo[2,3-b]pyridin...)copy SMILEScopy InChI
Affinity DataIC50: 63nMAssay Description:Inhibition of SGK1 by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195884(3-(3-chloro-4-fluorophenyl)-7-(3,4,5-trimethoxyphe...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296012(2-(4-(5-(naphthalen-2-yl)-1H-pyrrolo[2,3-b]pyridin...)copy SMILEScopy InChI
Affinity DataIC50: 125nMAssay Description:Inhibition of SGK1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03VCPubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296008(3-(4-(1H-tetrazol-5-yl)phenyl)-5-phenyl-1H-pyrrolo...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Inhibition of SGK1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03VCPubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195890(3-(4-chlorophenyl)-7-(3,4,5-trimethoxyphenyl)thien...)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM86638copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of human truncated JNK3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB1840PubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195893(3-(2,3-dichlorophenyl)-7-(3,4,5-trimethoxyphenyl)t...)copy SMILEScopy InChI
Affinity DataIC50: 230nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50411406(CHEMBL232601)copy SMILEScopy InChI
Affinity DataIC50: 251nMAssay Description:Inhibition of human truncated JNK3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB1840PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50411407(CHEMBL232610)copy SMILEScopy InChI
Affinity DataIC50: 251nMAssay Description:Inhibition of human truncated JNK3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB1840PubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM86638copy SMILEScopy InChI
Affinity DataIC50: 316nMAssay Description:Inhibition of human JNK2alpha2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB1840PubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50411406(CHEMBL232601)copy SMILEScopy InChI
Affinity DataIC50: 316nMAssay Description:Inhibition of human JNK2alpha2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB1840PubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195885(1-(4-(4-amino-7-(3-chlorophenyl)furo[3,2-c]pyridin...)copy SMILEScopy InChI
Affinity DataIC50: 389nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50411413(CHEMBL234838)copy SMILEScopy InChI
Affinity DataIC50: 398nMAssay Description:Inhibition of human truncated JNK3More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296007((4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 400nMAssay Description:Inhibition of SGK1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03VCPubMed
TargetIntegrase(Human immunodeficiency virus 1)
GlaxoSmithKline Research& Development

Curated by ChEMBL
LigandPNGBDBM50021589(CHEMBL3290944)copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant HIV1 integrase bound with donor DNA-SPA beads using [3H] target DNA as substrate assessed as strand transfer activity prein...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MG7R34PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50411417(CHEMBL391656)copy SMILEScopy InChI
Affinity DataIC50: 501nMAssay Description:Inhibition of human truncated JNK3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB1840PubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195883(7-bromo-3-(3-chloro-4-fluorophenyl)thieno[3,2-c]py...)copy SMILEScopy InChI
Affinity DataIC50: 575nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296011(2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin...)copy SMILEScopy InChI
Affinity DataIC50: 580nMAssay Description:Inhibition of SGK1-mediated epithelial sodium channel activity in human M-1 cells assessed as short circuit current by whole cell electrophysiologica...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03VCPubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296010(2-isobutyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-...)copy SMILEScopy InChI
Affinity DataIC50: 580nMAssay Description:Inhibition of SGK1-mediated epithelial sodium channel activity in human M-1 cells assessed as short circuit current by whole cell electrophysiologica...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03VCPubMed
TargetIntegrase(Human immunodeficiency virus 1)
GlaxoSmithKline Research& Development

Curated by ChEMBL
LigandPNGBDBM50021586(CHEMBL3290941)copy SMILEScopy InChI
Affinity DataIC50: 630nMAssay Description:Inhibition of recombinant HIV1 integrase bound with donor DNA-SPA beads using [3H] target DNA as substrate assessed as strand transfer activity prein...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MG7R34PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50411411(CHEMBL397356)copy SMILEScopy InChI
Affinity DataIC50: 631nMAssay Description:Inhibition of human truncated JNK3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB1840PubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296009(2-ethyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 710nMAssay Description:Inhibition of SGK1-mediated epithelial sodium channel activity in human M-1 cells assessed as short circuit current by whole cell electrophysiologica...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03VCPubMed
TargetIntegrase(Human immunodeficiency virus 1)
GlaxoSmithKline Research& Development

Curated by ChEMBL
LigandPNGBDBM50021585(CHEMBL3290940)copy SMILEScopy InChI
Affinity DataIC50: 790nMAssay Description:Inhibition of recombinant HIV1 integrase bound with donor DNA-SPA beads using [3H] target DNA as substrate assessed as strand transfer activity prein...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MG7R34PubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296013(2-methyl-2-(4-(5-(naphthalen-2-yl)-1H-pyrrolo[2,3-...)copy SMILEScopy InChI
Affinity DataIC50: 870nMAssay Description:Inhibition of SGK1-mediated epithelial sodium channel activity in human M-1 cells assessed as short circuit current by whole cell electrophysiologica...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03VCPubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296004(2-(4-(5-(naphthalen-2-yl)-1H-pyrrolo[2,3-b]pyridin...)copy SMILEScopy InChI
Affinity DataIC50: 880nMAssay Description:Inhibition of SGK1-mediated epithelial sodium channel activity in human M-1 cells assessed as short circuit current by whole cell electrophysiologica...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195885(1-(4-(4-amino-7-(3-chlorophenyl)furo[3,2-c]pyridin...)copy SMILEScopy InChI
Affinity DataIC50: 933nMAssay Description:Inhibition of human recombinant GST-6XHis-VEGFR2 by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50411408(CHEMBL391655)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human truncated JNK3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB1840PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50411419(CHEMBL233002 | SB-814597)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human truncated JNK3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB1840PubMed
TargetIntegrase(Human immunodeficiency virus 1)
GlaxoSmithKline Research& Development

Curated by ChEMBL
LigandPNGBDBM50021588(CHEMBL3290943)copy SMILEScopy InChI
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of recombinant HIV1 integrase bound with donor DNA-SPA beads using [3H] target DNA as substrate assessed as strand transfer activity prein...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MG7R34PubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296003(4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic ...)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of SGK1-mediated epithelial sodium channel activity in human M-1 cells assessed as short circuit current by whole cell electrophysiologica...More data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
GlaxoSmithKline Research& Development

Curated by ChEMBL
LigandPNGBDBM50021591(CHEMBL3290946)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant HIV1 integrase bound with donor DNA-SPA beads using [3H] target DNA as substrate assessed as strand transfer activity prein...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MG7R34PubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
GlaxoSmithKline K.K.

Curated by ChEMBL
LigandPNGBDBM50195880(3-(3-chloro-4-fluorophenyl)thieno[3,2-c]pyridin-4-...)copy SMILEScopy InChI
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB45D5PubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296014(2-methyl-2-(4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3...)copy SMILEScopy InChI
Affinity DataIC50: 1.46E+3nMAssay Description:Inhibition of SGK1-mediated epithelial sodium channel activity in human M-1 cells assessed as short circuit current by whole cell electrophysiologica...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03VCPubMed
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