Affinity DataKi: 0.800nMAssay Description:Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.80nMAssay Description:Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 3.5nMAssay Description:Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4.20nMAssay Description:Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 9.40nMAssay Description:Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 9.40nMAssay Description:Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 9.60nMAssay Description:Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 18nMAssay Description:Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 42nMAssay Description:Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 135nMAssay Description:Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 141nMAssay Description:Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 160nMAssay Description:Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 186nMAssay Description:Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 204nMAssay Description:Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 216nMAssay Description:Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 299nMAssay Description:Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 304nMAssay Description:Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 330nMAssay Description:Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 370nMAssay Description:Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 400nMAssay Description:Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 454nMAssay Description:Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 584nMAssay Description:Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 752nMAssay Description:Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 804nMAssay Description:Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 857nMAssay Description:Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 857nMAssay Description:Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 949nMAssay Description:Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.36E+3nMAssay Description:Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.54E+3nMAssay Description:Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.74E+3nMAssay Description:Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.07E+3nMAssay Description:Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.55E+3nMAssay Description:Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsMore data for this Ligand-Target Pair
TargetAcyl-CoA (8-3)-desaturase(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 0.520nMAssay Description:Inhibition of D5D in human HepG2 cells assessed as [14C]AA formation from [14C]DGLA preincubated for 30 mins followed by [14C]eicosatrienoic acid add...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2/delta(Rattus norvegicus (Rat))
Kyowa Hakko Kirin Co., Ltd.
US Patent
Kyowa Hakko Kirin Co., Ltd.
US Patent
Affinity DataIC50: 0.700nMT: 2°CAssay Description:A test compound (20 μL) diluted to 5 times of the final concentration with Binding buffer, [3H]-gabapentin diluted to 100 nmol/L with binding buff...More data for this Ligand-Target Pair
TargetAcyl-CoA (8-3)-desaturase(Rattus norvegicus)
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]T-3364366 from D5D in rat liver microsomal membrane preincubated for 15 mins followed by radioligand addition measured after 150 ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2/delta(Rattus norvegicus (Rat))
Kyowa Hakko Kirin Co., Ltd.
US Patent
Kyowa Hakko Kirin Co., Ltd.
US Patent
Affinity DataIC50: 1.20nMT: 2°CAssay Description:A test compound (20 μL) diluted to 5 times of the final concentration with Binding buffer, [3H]-gabapentin diluted to 100 nmol/L with binding buff...More data for this Ligand-Target Pair
TargetAcyl-CoA (8-3)-desaturase(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of D5D in human HepG2 cells assessed as [14C]AA formation from [14C]DGLA preincubated for 30 mins followed by [14C]eicosatrienoic acid add...More data for this Ligand-Target Pair
TargetAcyl-CoA (8-3)-desaturase(Rattus norvegicus)
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Displacement of [3H]T-3364366 from D5D in rat liver microsomal membrane preincubated for 15 mins followed by radioligand addition measured after 150 ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2/delta(Rattus norvegicus (Rat))
Kyowa Hakko Kirin Co., Ltd.
US Patent
Kyowa Hakko Kirin Co., Ltd.
US Patent
Affinity DataIC50: 2.60nMT: 2°CAssay Description:A test compound (20 μL) diluted to 5 times of the final concentration with Binding buffer, [3H]-gabapentin diluted to 100 nmol/L with binding buff...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2/delta(Rattus norvegicus (Rat))
Kyowa Hakko Kirin Co., Ltd.
US Patent
Kyowa Hakko Kirin Co., Ltd.
US Patent
Affinity DataIC50: 2.60nMT: 2°CAssay Description:A test compound (20 μL) diluted to 5 times of the final concentration with Binding buffer, [3H]-gabapentin diluted to 100 nmol/L with binding buff...More data for this Ligand-Target Pair