Compile Data Set for Download or QSAR
Found 844 with Last Name = 'karabelas' and Initial = 'k'
TargetP2Y purinoceptor 1(Homo sapiens (Human))
Pharmaron-Beijing Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50274638(CHEMBL4126156 | US10858355, Example 4)copy SMILEScopy InChI
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity to human P2Y1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27M0BFZPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489244(N-{6-[(5-{2-[(1S)-1-Cyclopropylethyl]-7-(methylsul...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489245(N-{6-[(5-{2-[(1S)-1-Cyclopropylethyl]-7-(methylsul...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM474007(N-(5-{2-[(1S)-1-Cyclopropylethyl]-7-(ethylsulfamoy...)copy SMILEScopy InChI
Affinity DataIC50: 0.398nMAssay Description:The activity of recombinant human PI3Kγ (aa144-1102)-6His was determined by measuring the ADP level after phosphorylation of DiC8-PIP2 using a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BZ6945US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM474011(N-(5-{2-[(1S)-1-Cyclopropylethyl]-7-({[1-(fluorome...)copy SMILEScopy InChI
Affinity DataIC50: 0.398nMAssay Description:The activity of recombinant human PI3Kγ (aa144-1102)-6His was determined by measuring the ADP level after phosphorylation of DiC8-PIP2 using a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BZ6945US Patent
LigandPNGBDBM50239550(CHEMBL4060741)copy SMILEScopy InChI
Affinity DataIC50: 0.398nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T43W8XPubMed
LigandPNGBDBM50239559(CHEMBL4073594)copy SMILEScopy InChI
Affinity DataIC50: 0.398nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489241(N-{6-[(5-{2-[(1S)-1-Cyclopropylethyl]-7-(methylsul...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489251(2-[(1S)-1-Cyclopropylethyl]-6-(2-{[6-(1,1-dioxido-...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489261(2-[(1S)-1-Cyclopropylethyl]-6-(4-methyl-2-{[6-(2-o...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489281(2-[(1S)-1-Cyclopropylethyl]-6-[2-({6-[(3R)-3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489283(2-[(1S)-1-Cyclopropylethyl]-6-[2-({6-[(3S)-3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489287(6-[2-({6-[(3S)-3-Hydroxy-2-oxopyrrolidin-1-yl]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489253(N-{6-[(5-{2-[(1S)-1-Cyclopropylethyl]-7-(ethylsulf...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489256(6-(4-Methyl-2-{[6-(2-oxo-1,3-oxazinan-3-yl)pyridin...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489257(6-(4-Methyl-2-{[6-(2-oxoimidazolidin-1-yl)pyridin-...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM474028(N-(5-{7-[(3-Cyanophenyl)sulfamoyl]-2-[(1S)-1-cyclo...)copy SMILEScopy InChI
Affinity DataIC50: 0.501nMAssay Description:The activity of recombinant human PI3Kγ (aa144-1102)-6His was determined by measuring the ADP level after phosphorylation of DiC8-PIP2 using a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BZ6945US Patent
LigandPNGBDBM50239549(CHEMBL4096646)copy SMILEScopy InChI
Affinity DataIC50: 0.501nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T43W8XPubMed
LigandPNGBDBM50239542(CHEMBL4069417)copy SMILEScopy InChI
Affinity DataIC50: 0.501nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T43W8XPubMed
LigandPNGBDBM50239552(CHEMBL4070433)copy SMILEScopy InChI
Affinity DataIC50: 0.501nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T43W8XPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM50579666(CHEMBL5081964)copy SMILES
Affinity DataIC50: 0.501nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7ZVJPubMed
LigandPNGBDBM50239540(CHEMBL4086230)copy SMILEScopy InChI
Affinity DataIC50: 0.501nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T43W8XPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489281(2-[(1S)-1-Cyclopropylethyl]-6-[2-({6-[(3R)-3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 0.501nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7ZVJPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM50579665(CHEMBL5082066)copy SMILES
Affinity DataIC50: 0.501nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7ZVJPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489264(6-(4-Methyl-2-{[6-(2-oxopyrrolidin-1-yl)pyridin-2-...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489237(5-(4-Methyl-2-{[6-(2-oxopyrrolidin-1-yl)pyridin-2-...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489248(2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-(4-methyl-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489247(2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-(4-methyl-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7ZVJPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM50274660(CHEMBL4128537 | US10858355, Example 12)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human 6His-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 10 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27M0BFZPubMed
LigandPNGBDBM50239553(CHEMBL4083582)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T43W8XPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM50579671(CHEMBL5090959)copy SMILES
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human PI3Kgamma assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7ZVJPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM50579667(CHEMBL5090799)copy SMILES
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7ZVJPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM50579668(CHEMBL5091438)copy SMILES
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7ZVJPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM50512861(CHEMBL4558527)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7ZVJPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489261(2-[(1S)-1-Cyclopropylethyl]-6-(4-methyl-2-{[6-(2-o...)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7ZVJPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM50274648(CHEMBL4127396 | US10858355, Example 22)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human 6His-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 10 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27M0BFZPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489248(2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-(4-methyl-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7ZVJPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM50274640(CHEMBL4126445)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human 6His-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 10 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27M0BFZPubMed
LigandPNGBDBM50239548(CHEMBL4080523)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T43W8XPubMed
LigandPNGBDBM50239557(CHEMBL4102634)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T43W8XPubMed
LigandPNGBDBM50239555(CHEMBL4094000)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T43W8XPubMed
LigandPNGBDBM50239551(CHEMBL4091365)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T43W8XPubMed
LigandPNGBDBM50239560(CHEMBL4081062)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:Inhibition of photolabeling of 24 kDa polypeptide in adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T43W8XPubMed
LigandPNGBDBM50239545(CHEMBL4092688)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T43W8XPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM474015(N-(5-{2-[(1S)-1-Cyclopropylethyl]-7-[(cyclopropyls...)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:The activity of recombinant human PI3Kγ (aa144-1102)-6His was determined by measuring the ADP level after phosphorylation of DiC8-PIP2 using a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BZ6945US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM474012(N-(5-{2-[(1S)-1-Cyclopropylethyl]-1-oxo-7-[(2,2,2-...)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:The activity of recombinant human PI3Kγ (aa144-1102)-6His was determined by measuring the ADP level after phosphorylation of DiC8-PIP2 using a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BZ6945US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM474008(N-(5-{2-[(1S)-1-Cyclopropylethyl]-7-(oxetan-3-ylsu...)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:The activity of recombinant human PI3Kγ (aa144-1102)-6His was determined by measuring the ADP level after phosphorylation of DiC8-PIP2 using a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BZ6945US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM50274648(CHEMBL4127396 | US10858355, Example 22)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:The activity of recombinant human PI3Kγ (aa144-1102)-6His was determined by measuring the ADP level after phosphorylation of DiC8-PIP2 using a c...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BZ6945US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM50274638(CHEMBL4126156 | US10858355, Example 4)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:The activity of recombinant human PI3Kγ (aa144-1102)-6His was determined by measuring the ADP level after phosphorylation of DiC8-PIP2 using a c...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BZ6945US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489275(2-[(1S)-1-Cyclopropylethyl]-6-(2-{[6-(5,5-dimethyl...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
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