Compile Data Set for Download or QSAR
Found 325 with Last Name = 'packman' and Initial = 'k'
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12621(2,4-Diamino-5-ketopyrimidine 39 | 5-[(2,3-difluoro...)copy SMILEScopy InChI
Affinity DataKi:  1nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12623(2,4-Diamino-5-ketopyrimidine 41 | 2-N-(1-methanesu...)copy SMILEScopy InChI
Affinity DataKi:  1nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12621(2,4-Diamino-5-ketopyrimidine 39 | 5-[(2,3-difluoro...)copy SMILEScopy InChI
Affinity DataKi:  1nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12623(2,4-Diamino-5-ketopyrimidine 41 | 2-N-(1-methanesu...)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12619(2,4-Diamino-5-ketopyrimidine 37 | 5-[(2-fluoro-6-m...)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12621(2,4-Diamino-5-ketopyrimidine 39 | 5-[(2,3-difluoro...)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12623(2,4-Diamino-5-ketopyrimidine 41 | 2-N-(1-methanesu...)copy SMILEScopy InChI
Affinity DataKi:  5nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12622(2,4-Diamino-5-ketopyrimidine 40 | 5-[(4,5-difluoro...)copy SMILEScopy InChI
Affinity DataKi:  6nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12622(2,4-Diamino-5-ketopyrimidine 40 | 5-[(4,5-difluoro...)copy SMILEScopy InChI
Affinity DataKi:  6nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12617(2,4-Diamino-5-ketopyrimidine 35 | 5-[(5-fluoro-2-m...)copy SMILEScopy InChI
Affinity DataKi:  7nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12617(2,4-Diamino-5-ketopyrimidine 35 | 5-[(5-fluoro-2-m...)copy SMILEScopy InChI
Affinity DataKi:  7nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetAndrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50570254(CHEMBL4865865)copy SMILES
Affinity DataKi:  8.40nMAssay Description:Binding affinity to wild-type androgen receptor in human LNCaP cells assessed as inhibition constant incubated for 24 hrs by Cheng-Prusoff equation a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29027KPPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12619(2,4-Diamino-5-ketopyrimidine 37 | 5-[(2-fluoro-6-m...)copy SMILEScopy InChI
Affinity DataKi:  13nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12617(2,4-Diamino-5-ketopyrimidine 35 | 5-[(5-fluoro-2-m...)copy SMILEScopy InChI
Affinity DataKi:  14nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12611(2,4-Diamino-5-ketopyrimidine 29 | 2-N-(1-methanesu...)copy SMILEScopy InChI
Affinity DataKi:  14nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12622(2,4-Diamino-5-ketopyrimidine 40 | 5-[(4,5-difluoro...)copy SMILEScopy InChI
Affinity DataKi:  14nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12620(2,4-Diamino-5-ketopyrimidine 38 | 5-[(2,6-difluoro...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12612(2,4-Diamino-5-ketopyrimidine 30 | 2-N-[1-(ethanesu...)copy SMILEScopy InChI
Affinity DataKi:  16nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12620(2,4-Diamino-5-ketopyrimidine 38 | 5-[(2,6-difluoro...)copy SMILEScopy InChI
Affinity DataKi:  17nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetAndrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50425732(ENZALUTAMIDE | US10053433, FC 4.129 | US10806720, ...)copy SMILEScopy InChI
Affinity DataKi:  17nMAssay Description:Binding affinity to wild-type androgen receptor in human LNCaP cells assessed as inhibition constant incubated for 24 hrs by Cheng-Prusoff equation a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29027KPPubMedDrugBank
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12619(2,4-Diamino-5-ketopyrimidine 37 | 5-[(2-fluoro-6-m...)copy SMILEScopy InChI
Affinity DataKi:  17nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12616(2,4-Diamino-5-ketopyrimidine 34 | 5-[(4-fluoro-2-m...)copy SMILEScopy InChI
Affinity DataKi:  21nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM468103((R)-N-(1-Acryloylpiperidin-3-yl)-5-(*S)-(6-(cyclop...)copy SMILES
Affinity DataKi:  22nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6HZ3PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12611(2,4-Diamino-5-ketopyrimidine 29 | 2-N-(1-methanesu...)copy SMILEScopy InChI
Affinity DataKi:  24nM ΔG°:  -45.2kJ/molepH: 7.0 T: 2°CAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM468000((R)-N-(1-Acryloylpiperidin-3-yl)-5-(*S)-(4-methyl-...)copy SMILES
Affinity DataKi:  28nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6HZ3PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12611(2,4-Diamino-5-ketopyrimidine 29 | 2-N-(1-methanesu...)copy SMILEScopy InChI
Affinity DataKi:  28nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM467718((R)-N-(1-Acryloylpyrrolidin-3-yl)-5-(2-methyl-4-(2...)copy SMILES
Affinity DataKi:  29nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6HZ3PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM467367((R)-N-(1-Acryloylpiperidin-3-yl)-4-oxo-5-(4-phenox...)copy SMILES
Affinity DataKi:  32nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6HZ3PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12618(2,4-Diamino-5-ketopyrimidine 36 | 5-[(5-chloro-2-m...)copy SMILEScopy InChI
Affinity DataKi:  36nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12620(2,4-Diamino-5-ketopyrimidine 38 | 5-[(2,6-difluoro...)copy SMILEScopy InChI
Affinity DataKi:  38nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12612(2,4-Diamino-5-ketopyrimidine 30 | 2-N-[1-(ethanesu...)copy SMILEScopy InChI
Affinity DataKi:  43nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12612(2,4-Diamino-5-ketopyrimidine 30 | 2-N-[1-(ethanesu...)copy SMILEScopy InChI
Affinity DataKi:  51nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM468010((R)-N-(1-Acryloylpiperidin-3-yl)-5-(6-cyclobutoxy-...)copy SMILES
Affinity DataKi:  64nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6HZ3PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12609(1-[4-({4-amino-5-[(2-methoxyphenyl)carbonyl]pyrimi...)copy SMILEScopy InChI
Affinity DataKi:  66nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM467836((R)-N-(1-Acryloylpiperidin-3-yl)-5-(3-methyl-5-phe...)copy SMILES
Affinity DataKi:  70nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6HZ3PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12616(2,4-Diamino-5-ketopyrimidine 34 | 5-[(4-fluoro-2-m...)copy SMILEScopy InChI
Affinity DataKi:  84nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12610(1-[4-({4-amino-5-[(2-methoxyphenyl)carbonyl]pyrimi...)copy SMILEScopy InChI
Affinity DataKi:  98nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12608(2,4-Diamino-5-ketopyrimidine 26 | 4-[4-Amino-5-(2-...)copy SMILEScopy InChI
Affinity DataKi:  110nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12618(2,4-Diamino-5-ketopyrimidine 36 | 5-[(5-chloro-2-m...)copy SMILEScopy InChI
Affinity DataKi:  133nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM468007((R)-N-(1-Acryloylpiperidin-3-yl)-5-(*S)-(6-isobuty...)copy SMILES
Affinity DataKi:  145nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6HZ3PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12604(2,4-Diamino-5-ketopyrimidine 22 | 5-[(2-methoxyphe...)copy SMILEScopy InChI
Affinity DataKi:  159nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12609(1-[4-({4-amino-5-[(2-methoxyphenyl)carbonyl]pyrimi...)copy SMILEScopy InChI
Affinity DataKi:  181nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12616(2,4-Diamino-5-ketopyrimidine 34 | 5-[(4-fluoro-2-m...)copy SMILEScopy InChI
Affinity DataKi:  193nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM468124((R)-N-(1-Acryloylpiperidin-3-yl)-5-(*S)-(6-isoprop...)copy SMILES
Affinity DataKi:  208nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6HZ3PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12608(2,4-Diamino-5-ketopyrimidine 26 | 4-[4-Amino-5-(2-...)copy SMILEScopy InChI
Affinity DataKi:  246nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12624(2,4-Diamino-5-ketopyrimidine 42 | 2-N-(1-methanesu...)copy SMILEScopy InChI
Affinity DataKi:  267nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12610(1-[4-({4-amino-5-[(2-methoxyphenyl)carbonyl]pyrimi...)copy SMILEScopy InChI
Affinity DataKi:  278nMAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Hoffmann-La Roche Inc.

LigandPNGBDBM12609(1-[4-({4-amino-5-[(2-methoxyphenyl)carbonyl]pyrimi...)copy SMILEScopy InChI
Affinity DataKi:  327nM ΔG°:  -38.5kJ/molepH: 7.0 T: 2°CAssay Description:Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VB2PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM467845((R)-N-(1-Acryloylpiperidin-3-yl)-4-oxo-5-(6-phenox...)copy SMILES
Affinity DataKi:  354nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6HZ3PubMed
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