Compile Data Set for Download or QSAR
Found 562 with Last Name = 'spear' and Initial = 'kl'
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
G. D. Searle and Company

Curated by ChEMBL
LigandPNGBDBM50016816(CHEMBL412913 | S-S-C-F-G-G-R-I-D-R-I-G-A-Q-S-G-L-G...)copy SMILEScopy InChI
Affinity DataKi:  0.25nMAssay Description:Apparent binding affinity for non-vasorelaxant receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FN156BPubMed
TargetAtrial natriuretic peptide receptor 2(Homo sapiens (Human))
G. D. Searle and Company

Curated by ChEMBL
LigandPNGBDBM50228215(CHEMBL3349651)copy SMILEScopy InChI
Affinity DataKi:  0.25nMAssay Description:Apparent binding constant against multiple binding sitesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26112J6PubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50433372(CHEMBL2375520)copy SMILEScopy InChI
Affinity DataKi:  1.70nMAssay Description:Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92CPCPubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50260725(4H-thieno[3,2-b]pyrrole-5-carboxylic acid | CHEMBL...)copy SMILEScopy InChI
Affinity DataKi:  3.5nMAssay Description:Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serineMore data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50260722(4-(4-chlorophenethyl)-1H-pyrrole-2-carboxylic acid...)copy SMILEScopy InChI
Affinity DataKi:  7.20nMAssay Description:Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serineMore data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50206007(3-Hydroxy-chromen-2-one | 3-hydroxy-2H-chromen-2-o...)copy SMILEScopy InChI
Affinity DataKi:  13nMAssay Description:Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serineMore data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50433371(CHEMBL2375519)copy SMILEScopy InChI
Affinity DataKi:  190nMAssay Description:Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92CPCPubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)copy SMILEScopy InChI
Affinity DataKi:  2.00E+3nMAssay Description:Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92CPCPubMed
TargetD-amino-acid oxidase(Sus scrofa (pig))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50004955(1H-Indole-2-carboxylic acid | CHEMBL278390 | Indol...)copy SMILEScopy InChI
Affinity DataKi:  3.40E+3nMAssay Description:Competitive inhibition of pig kidney DAAO in presence of D-alanineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92CPCPubMed
TargetType-1 angiotensin II receptor A/B(RAT)
G. D. Searle and Company

Curated by ChEMBL
LigandPNGBDBM50452851(CHEMBL2373017)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Concentration required to 50% inhibition in specific binding of [125- I]A-II to Angiotensin II receptor in rat uterine membraneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R78D70PubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor Inc.

Curated by ChEMBL
LigandPNGBDBM50334773(CHEMBL1642904 | trans-((2R,4S)-4-(3,4-dichlorophen...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2639Q0MPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor Inc.

Curated by ChEMBL
LigandPNGBDBM50334781(CHEMBL1642912 | Cis-2-((2S,4S)-4-(3,4-dichlorophen...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2639Q0MPubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337829(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dimethylm...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S46S72PubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337830(CHEMBL1683875 | N-((1-(3,4-dichlorophenyl)cyclohex...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S46S72PubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337831(CHEMBL1683899 | N,N-dimethyl-1-(1-(naphthalen-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S46S72PubMed
TargetType-1 angiotensin II receptor A/B(RAT)
G. D. Searle and Company

Curated by ChEMBL
LigandPNGBDBM50228335(CHEMBL263034)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Concentration required to 50% inhibition in specific binding of [125- I]A-II to Angiotensin II receptor in rat uterine membraneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R78D70PubMed
TargetType-1 angiotensin II receptor A/B(RAT)
G. D. Searle and Company

Curated by ChEMBL
LigandPNGBDBM50030815(CHEMBL404594)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Concentration required to 50% inhibition in specific binding of [125- I]A-II to Angiotensin II receptor from rat uterine membraneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R78D70PubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor Inc.

Curated by ChEMBL
LigandPNGBDBM50334787(CHEMBL1642902 | cis-((2S,4S)-4-(3,4-dichlorophenyl...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2639Q0MPubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337832(CHEMBL1683873 | N-((1-(3,4-dichlorophenyl)cyclohex...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S46S72PubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337823(1-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)pyrrol...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S46S72PubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337822(4-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)morpho...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S46S72PubMed
TargetType-1 angiotensin II receptor A/B(RAT)
G. D. Searle and Company

Curated by ChEMBL
LigandPNGBDBM50228272(CHEMBL411997)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:pA2 value for Angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R78D70PubMed
TargetType-1 angiotensin II receptor A/B(RAT)
G. D. Searle and Company

Curated by ChEMBL
LigandPNGBDBM50228195(Angiotensin Ii | CHEBI:2719)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Concentration required to 50% inhibition in specific binding of [125- I]A-II to Angiotensin II receptor in rat uterine membraneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R78D70PubMed
TargetType-1 angiotensin II receptor A/B(RAT)
G. D. Searle and Company

Curated by ChEMBL
LigandPNGBDBM50228308(CHEMBL413740)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Concentration required to 50% inhibition in specific binding of [125- I]A-II to Angiotensin II receptor in rat uterine membraneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R78D70PubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor Inc.

Curated by ChEMBL
LigandPNGBDBM50028094((1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-te...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor Inc.

Curated by ChEMBL
LigandPNGBDBM50334770(CHEMBL1642900 | cis-(2S,4S)-4-(3,4-dichlorophenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2639Q0MPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor Inc.

Curated by ChEMBL
LigandPNGBDBM50334916(1-(3,4-dichlorophenyl)-N,N-dimethyl-1,2,3,4-tetrah...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant 5HT transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FWSPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor Inc.

Curated by ChEMBL
LigandPNGBDBM50337833(CHEMBL1683902 | N,N-dimethyl-1-(1-(naphthalen-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S46S72PubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337833(CHEMBL1683902 | N,N-dimethyl-1-(1-(naphthalen-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S46S72PubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50433372(CHEMBL2375520)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMAssay Description:Competitive inhibition of human recombinant DAAO after 1 hr by coupled enzyme assay in presence of D-serineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92CPCPubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337834(CHEMBL1683872 | N-((1-(3,4-dichlorophenyl)cyclohex...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S46S72PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337829(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dimethylm...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S46S72PubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor Inc.

Curated by ChEMBL
LigandPNGBDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)copy SMILEScopy InChI
Affinity DataIC50: 5.20nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2639Q0MPubMedDrugBank
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50260725(4H-thieno[3,2-b]pyrrole-5-carboxylic acid | CHEMBL...)copy SMILEScopy InChI
Affinity DataIC50: 5.40nMAssay Description:Competitive inhibition of human recombinant DAAO after 1 hr by coupled enzyme assay in presence of D-serineMore data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50260725(4H-thieno[3,2-b]pyrrole-5-carboxylic acid | CHEMBL...)copy SMILEScopy InChI
Affinity DataIC50: 5.40nMAssay Description:Inhibition of DAAO (unknown origin)More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor Inc.

Curated by ChEMBL
LigandPNGBDBM50334764(CHEMBL1642894 | trans-(2R,4S)-4-(3,4-dichloropheny...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2639Q0MPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor Inc.

Curated by ChEMBL
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CV4J2PPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor Inc.

Curated by ChEMBL
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CV4J2PPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337818(CHEMBL1683876 | N-((1-(3,4-dichlorophenyl)cyclohex...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S46S72PubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor Inc.

Curated by ChEMBL
LigandPNGBDBM50334768(CHEMBL1642898 | trans-(2R,4S)-4-(3,4-dichloropheny...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2639Q0MPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor Inc.

Curated by ChEMBL
LigandPNGBDBM50334920((R)-1-(3,4-dichlorophenyl)-N,N-dimethyl-1,2,3,4-te...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant 5HT transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FWSPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337911((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dim...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CV4J2PPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337911((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dim...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CV4J2PPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337833(CHEMBL1683902 | N,N-dimethyl-1-(1-(naphthalen-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S46S72PubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor Inc.

Curated by ChEMBL
LigandPNGBDBM50334766(CHEMBL1642896 | cis-(2S,4S)-4-(3,4-dichlorophenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2639Q0MPubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50334919((R)-1-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrah...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FWSPubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Sepracor Inc.

Curated by ChEMBL
LigandPNGBDBM50334783(CHEMBL1642914 | trans-(1S,2S)-1-(3,4-dichloropheny...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2639Q0MPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM22417(3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-ami...)copy SMILEScopy InChI
Affinity DataIC50: 8.30nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human NET expressed in MDCK cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2639Q0MPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor Inc.

Curated by ChEMBL
LigandPNGBDBM50334775(CHEMBL1642906 | trans-1-((2R,4S)-4-(3,4-dichloroph...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2639Q0MPubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337835(1-(1-(3,4-dichlorophenyl)cyclopentyl)-N,N-dimethyl...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S46S72PubMed
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