Compile Data Set for Download or QSAR
Found 79 with Last Name = 'johanson' and Initial = 'ko'
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50083761(CHEMBL87429 | [3-Oxo-8-[3-(pyridin-2-ylamino)-prop...)copy SMILEScopy InChI
Affinity DataKi:  0.900nMAssay Description:Binding affinity for Vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q290230DPubMed
TargetCyclin-A2/Cyclin-dependent kinase 1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.4 T: 2°CAssay Description:In vitro CDK enzymatic assay using purified CDK mixed with cyclin A, was incubated with substrate, and test compounds in the presence of 1.4 uM ATP/ ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798PFPubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
GSK

LigandPNGBDBM17461(1,2,3-triazole analogue, 17 | 5-(4-iodophenyl)-1H-...)copy SMILEScopy InChI
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3537PubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
GSK

LigandPNGBDBM17468(1,2,3-triazole analogue, 24 | 5-(3,4-dibromophenyl...)copy SMILEScopy InChI
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3537PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50083763(CHEMBL86992 | [(S)-8-[2-(6-Methylamino-pyridin-2-y...)copy SMILEScopy InChI
Affinity DataKi:  1.20nMAssay Description:Binding affinity for Vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q290230DPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50083764(CHEMBL421533 | [3-Oxo-8-[3-(pyridin-2-ylamino)-pro...)copy SMILEScopy InChI
Affinity DataKi:  1.30nMAssay Description:Binding affinity for Vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q290230DPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50083762(CHEMBL314022 | {2-Methyl-3-oxo-8-[3-(pyridin-2-yla...)copy SMILEScopy InChI
Affinity DataKi:  1.90nMAssay Description:Binding affinity for Vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q290230DPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059133(CHEMBL50106 | SB-223245 | {(S)-7-[(1H-Benzoimidazo...)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Binding affinity for Vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q290230DPubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126595(3-Phenyl-4-{4-[2-(5,6,7,8-tetrahydro-[1,8]naphthyr...)copy SMILEScopy InChI
Affinity DataKi:  2.5nMAssay Description:Binding affinity for alphav/beta 3 vitronectin receptor in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FN15K8PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126595(3-Phenyl-4-{4-[2-(5,6,7,8-tetrahydro-[1,8]naphthyr...)copy SMILEScopy InChI
Affinity DataKi:  2.5nMAssay Description:Binding affinity for alphaV-beta5 vitronectin receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FN15K8PubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50078714(CHEMBL288493 | SB-265123 | {(S)-3-[3-(Pyridin-2-yl...)copy SMILEScopy InChI
Affinity DataKi:  2.60nMAssay Description:Binding affinity for alphaV-beta3 vitronectin receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FN15K8PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataKi:  2.90nM ΔG°:  -48.2kJ/molepH: 7.4 T: 2°CAssay Description:In vitro CDK enzymatic assay using purified CDK mixed with cyclin A, was incubated with substrate, and test compounds in the presence of 1.4 uM ATP/ ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798PFPubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
GSK

LigandPNGBDBM17474(1,2,3-triazole analogue, 30 | 4-methyl-2-(1H-1,2,3...)copy SMILEScopy InChI
Affinity DataKi:  3nM ΔG°:  -48.2kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3537PubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
GSK

LigandPNGBDBM17460(1,2,3-triazole analogue, 16 | 5-(4-bromophenyl)-1H...)copy SMILEScopy InChI
Affinity DataKi:  3nM ΔG°:  -48.2kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3537PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50078714(CHEMBL288493 | SB-265123 | {(S)-3-[3-(Pyridin-2-yl...)copy SMILEScopy InChI
Affinity DataKi:  4nMAssay Description:Binding affinity for alphaIIb-beta3 vitronectin receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FN15K8PubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
GSK

LigandPNGBDBM17467(1,2,3-triazole analogue, 23 | 5-(3-bromophenyl)-1H...)copy SMILEScopy InChI
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3537PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50078714(CHEMBL288493 | SB-265123 | {(S)-3-[3-(Pyridin-2-yl...)copy SMILEScopy InChI
Affinity DataKi:  4nMAssay Description:Binding affinity for Vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q290230DPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM17054((2S,3R,4R,6R,18R)-18-hydroxy-3-methoxy-2-methyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  5.60nM ΔG°:  -49.0kJ/molepH: 7.4 T: 2°CAssay Description:In vitro Chk1 enzymatic assay using purified enzyme, was incubated with substrate, and test compounds in the presence of 10 uM ATP/ [gamma-32P] ATP. ...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM17140((15R,18R)-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1...)copy SMILEScopy InChI
Affinity DataKi:  5.60nM ΔG°:  -46.6kJ/molepH: 7.4 T: 2°CAssay Description:In vitro CDK enzymatic assay using purified CDK mixed with cyclin A, was incubated with substrate, and test compounds in the presence of 1.4 uM ATP/ ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798PFPubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
GSK

LigandPNGBDBM17459(1,2,3-triazole analogue, 15 | 5-(4-chlorophenyl)-1...)copy SMILEScopy InChI
Affinity DataKi:  6nM ΔG°:  -46.5kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3537PubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
GSK

LigandPNGBDBM17473(1,2,3-triazole analogue, 29 | 3-methyl-2-(1H-1,2,3...)copy SMILEScopy InChI
Affinity DataKi:  6nM ΔG°:  -46.5kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3537PubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126594(3-Phenyl-4-{4-[3-(pyridin-2-ylamino)-propoxy]-phen...)copy SMILEScopy InChI
Affinity DataKi:  6nMAssay Description:Binding affinity for alphaV-beta3 vitronectin receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FN15K8PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126597(4-{4-[2-(6-Methylamino-pyridin-2-yl)-ethoxy]-pheny...)copy SMILEScopy InChI
Affinity DataKi:  7nMAssay Description:Binding affinity for alphaV-beta3 vitronectin receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FN15K8PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataKi:  7.80nM ΔG°:  -48.1kJ/molepH: 7.4 T: 2°CAssay Description:In vitro Chk1 enzymatic assay using purified enzyme, was incubated with substrate, and test compounds in the presence of 10 uM ATP/ [gamma-32P] ATP. ...More data for this Ligand-Target Pair
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
GSK

LigandPNGBDBM17475(1,2,3-triazole analogue, 31 | 5-methyl-2-(1H-1,2,3...)copy SMILEScopy InChI
Affinity DataKi:  8nM ΔG°:  -45.7kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3537PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126596(3-Phenyl-4-{4-[3-(pyridin-2-ylamino)-propoxy]-phen...)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Binding affinity for alphav/beta 3 vitronectin receptor in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FN15K8PubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
GSK

LigandPNGBDBM17469(1,2,3-triazole analogue, 25 | 5-(1-benzofuran-2-yl...)copy SMILEScopy InChI
Affinity DataKi:  13nM ΔG°:  -44.6kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3537PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM17140((15R,18R)-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1...)copy SMILEScopy InChI
Affinity DataKi:  15nM ΔG°:  -46.5kJ/molepH: 7.4 T: 2°CAssay Description:In vitro Chk1 enzymatic assay using purified enzyme, was incubated with substrate, and test compounds in the presence of 10 uM ATP/ [gamma-32P] ATP. ...More data for this Ligand-Target Pair
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
GSK

LigandPNGBDBM17447(1,2,3-triazole analogue, 3 | 5-(4-methylphenyl)-1H...)copy SMILEScopy InChI
Affinity DataKi:  15nM ΔG°:  -44.2kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3537PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM17140((15R,18R)-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1...)copy SMILEScopy InChI
Affinity DataKi:  16nM ΔG°:  -45.2kJ/molepH: 7.5 T: 2°CAssay Description:CDK4 and cyclin D1 were expressed in a baculovirus expression system and subsequently purified. The catalytic activity of the CDK4 protein was assaye...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798PFPubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
GSK

LigandPNGBDBM17466(1,2,3-triazole analogue, 22 | 5-(3-iodophenyl)-1H-...)copy SMILEScopy InChI
Affinity DataKi:  16nM ΔG°:  -44.0kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3537PubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
GSK

LigandPNGBDBM17462(1,2,3-triazole analogue, 18 | 5-(3-methylphenyl)-1...)copy SMILEScopy InChI
Affinity DataKi:  18nM ΔG°:  -43.8kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50083760(CHEMBL86991 | [3-Oxo-8-[3-(pyridin-2-ylamino)-prop...)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Binding affinity for Vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q290230DPubMed
TargetCyclin-A2/Cyclin-dependent kinase 1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM17140((15R,18R)-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1...)copy SMILEScopy InChI
Affinity DataKi:  23nM ΔG°:  -43.2kJ/molepH: 7.4 T: 2°CAssay Description:In vitro CDK enzymatic assay using purified CDK mixed with cyclin A, was incubated with substrate, and test compounds in the presence of 1.4 uM ATP/ ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798PFPubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
GSK

LigandPNGBDBM17465(1,2,3-triazole analogue, 21 | N-benzyl-3-(1H-1,2,3...)copy SMILEScopy InChI
Affinity DataKi:  29nM ΔG°:  -42.6kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3537PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM17054((2S,3R,4R,6R,18R)-18-hydroxy-3-methoxy-2-methyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  30nM ΔG°:  -42.5kJ/molepH: 7.4 T: 2°CAssay Description:In vitro CDK enzymatic assay using purified CDK mixed with cyclin A, was incubated with substrate, and test compounds in the presence of 1.4 uM ATP/ ...More data for this Ligand-Target Pair
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
GSK

LigandPNGBDBM17455(1,2,3-triazole analogue, 11 | 5-(4-ethylphenyl)-1H...)copy SMILEScopy InChI
Affinity DataKi:  30nM ΔG°:  -42.5kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3537PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126594(3-Phenyl-4-{4-[3-(pyridin-2-ylamino)-propoxy]-phen...)copy SMILEScopy InChI
Affinity DataKi:  32nMAssay Description:Binding affinity for alphaV-beta5 vitronectin receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FN15K8PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataKi:  41nM ΔG°:  -42.9kJ/molepH: 7.5 T: 2°CAssay Description:CDK4 and cyclin D1 were expressed in a baculovirus expression system and subsequently purified. The catalytic activity of the CDK4 protein was assaye...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798PFPubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
GSK

LigandPNGBDBM17470(1,2,3-triazole analogue, 26 | 2-(1H-1,2,3-triazol-...)copy SMILEScopy InChI
Affinity DataKi:  41nM ΔG°:  -41.7kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3537PubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
GSK

LigandPNGBDBM17476(1,2,3-triazole analogue, 32 | 2-methyl-6-(1H-1,2,3...)copy SMILEScopy InChI
Affinity DataKi:  52nM ΔG°:  -41.2kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3537PubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
GSK

LigandPNGBDBM17449(1,2,3-triazole analogue, 5 | 1H,4H-indeno[1,2-d][1...)copy SMILEScopy InChI
Affinity DataKi:  52nM ΔG°:  -41.2kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3537PubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
GSK

LigandPNGBDBM17448(1,2,3-triazole analogue, 4 | 5-phenyl-1H-1,2,3-tri...)copy SMILEScopy InChI
Affinity DataKi:  70nM ΔG°:  -40.4kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3537PubMed
TargetCyclin-A2/Cyclin-dependent kinase 1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM17054((2S,3R,4R,6R,18R)-18-hydroxy-3-methoxy-2-methyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  95nM ΔG°:  -39.7kJ/molepH: 7.4 T: 2°CAssay Description:In vitro CDK enzymatic assay using purified CDK mixed with cyclin A, was incubated with substrate, and test compounds in the presence of 1.4 uM ATP/ ...More data for this Ligand-Target Pair
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
GSK

LigandPNGBDBM17452(1,2,3-triazole analogue, 8 | 5-(2-methylphenyl)-1H...)copy SMILEScopy InChI
Affinity DataKi:  112nM ΔG°:  -39.3kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3537PubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
GSK

LigandPNGBDBM17453(1,2,3-triazole analogue, 9 | 5-(2-methoxyphenyl)-1...)copy SMILEScopy InChI
Affinity DataKi:  150nM ΔG°:  -38.6kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3537PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126598(3-Phenyl-4-{4-[3-(pyridin-2-ylamino)-propoxy]-phen...)copy SMILEScopy InChI
Affinity DataKi:  170nMAssay Description:Binding affinity for alphaV-beta3 vitronectin receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FN15K8PubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
GSK

LigandPNGBDBM17471(1,2,3-triazole analogue, 27 | 3-(1H-1,2,3-triazol-...)copy SMILEScopy InChI
Affinity DataKi:  260nM ΔG°:  -37.2kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3537PubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
GSK

LigandPNGBDBM17464(1,2,3-triazole analogue, 20 | 3-(1H-1,2,3-triazol-...)copy SMILEScopy InChI
Affinity DataKi:  280nM ΔG°:  -37.0kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3537PubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
GSK

LigandPNGBDBM17450(4-(4-methylphenyl)-1H-pyrazole | pyrazole analogue...)copy SMILEScopy InChI
Affinity DataKi:  280nM ΔG°:  -37.0kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3537PubMed
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