Compile Data Set for Download or QSAR
Found 129 with Last Name = 'auger' and Initial = 'kr'
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataKi:  1.70nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220180(CHEMBL243669 | N-[3-fluoro-4'-(trifluoromethyl)-4-...)copy SMILEScopy InChI
Affinity DataKi:  3.5nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220182(CHEMBL390629 | N-[4'-(trifluoromethyl)-4-biphenyly...)copy SMILEScopy InChI
Affinity DataKi:  6.20nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11 [A356T](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataKi:  66nMpH: 6.8Assay Description:wild-type HCT116 selected at 6WT-6x the IC95More data for this Ligand-Target Pair
TargetKinesin-like protein KIF11 [A356T](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataKi:  109nMpH: 6.8Assay Description:wild-type HCT116 selected at 3 the IC95More data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220169(CHEMBL244933 | N-[4'-(trifluoromethyl)-4-biphenyly...)copy SMILEScopy InChI
Affinity DataKi:  120nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36351(CID148124 | Docetaxel)copy SMILEScopy InChI
Affinity DataIC50: 0.180nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36351(CID148124 | Docetaxel)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36351(CID148124 | Docetaxel)copy SMILEScopy InChI
Affinity DataIC50: 0.230nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36351(CID148124 | Docetaxel)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36351(CID148124 | Docetaxel)copy SMILEScopy InChI
Affinity DataIC50: 0.310nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36351(CID148124 | Docetaxel)copy SMILEScopy InChI
Affinity DataIC50: 0.350nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataIC50: 0.450nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)copy SMILEScopy InChI
Affinity DataIC50: 0.460nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36351(CID148124 | Docetaxel)copy SMILEScopy InChI
Affinity DataIC50: 0.590nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)copy SMILEScopy InChI
Affinity DataIC50: 0.720nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataIC50: 0.830nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
LigandPNGBDBM50091691(CHEMBL3582356)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP04JFPubMed
LigandPNGBDBM50091689(CHEMBL3582354)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP04JFPubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
LigandPNGBDBM50091692(CHEMBL3582357)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP04JFPubMed
LigandPNGBDBM50091696(CHEMBL3582351)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP04JFPubMed
LigandPNGBDBM50091695(CHEMBL3582350)copy SMILEScopy InChI
Affinity DataIC50: 4.40nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP04JFPubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220180(CHEMBL243669 | N-[3-fluoro-4'-(trifluoromethyl)-4-...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
LigandPNGBDBM50091695(CHEMBL3582350)copy SMILEScopy InChI
Affinity DataIC50: 6.5nMAssay Description:Inhibition of wild type his-tagged PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP04JFPubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataIC50: 6.90nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
LigandPNGBDBM50091689(CHEMBL3582354)copy SMILEScopy InChI
Affinity DataIC50: 8.5nMAssay Description:Inhibition of PI3Kalpha H1047R mutant (unknown origin)More data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36351(CID148124 | Docetaxel)copy SMILEScopy InChI
Affinity DataIC50: 8.70nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
LigandPNGBDBM50091696(CHEMBL3582351)copy SMILEScopy InChI
Affinity DataIC50: 9.60nMAssay Description:Inhibition of wild type his-tagged PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP04JFPubMed
LigandPNGBDBM50091696(CHEMBL3582351)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP04JFPubMed
LigandPNGBDBM50091689(CHEMBL3582354)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of wild type his-tagged PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM50091695(CHEMBL3582350)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP04JFPubMed
LigandPNGBDBM50091696(CHEMBL3582351)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of PI3Kalpha H1047R mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP04JFPubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220195(CHEMBL243885 | N-[4'-(trifluoromethyl)-4-biphenyly...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
LigandPNGBDBM50091695(CHEMBL3582350)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of PI3Kalpha H1047R mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP04JFPubMed
LigandPNGBDBM50091691(CHEMBL3582356)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of wild type his-tagged PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP04JFPubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220159(CHEMBL389589 | N-[3'-fluoro-4'-(trifluoromethyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220185(1-(3-fluoro-4'-(trifluoromethyl)biphenyl-4-yl)urea...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
LigandPNGBDBM50091694(CHEMBL3582359)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of PI3Kalpha H1047R mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP04JFPubMed
LigandPNGBDBM50091694(CHEMBL3582359)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of wild type his-tagged PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP04JFPubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220182(CHEMBL390629 | N-[4'-(trifluoromethyl)-4-biphenyly...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
LigandPNGBDBM50091694(CHEMBL3582359)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP04JFPubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)copy SMILEScopy InChI
Affinity DataIC50: 22nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220201(CHEMBL243431 | N-[3-amino-4'-(trifluoromethyl)-4-b...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
LigandPNGBDBM50091694(CHEMBL3582359)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP04JFPubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220155(CHEMBL244697 | N-[3'-nitro-4'-(trifluoromethyl)-4-...)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
LigandPNGBDBM50091697(CHEMBL3582353)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of PI3Kalpha H1047R mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP04JFPubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220176(CHEMBL242181 | N-[4-(2,2-difluoro-1,3-benzodioxol-...)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29023H4PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataIC50: 36nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
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