Compile Data Set for Download or QSAR
Found 53 with Last Name = 'kilgore' and Initial = 'ks'
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50220087(2-(3,5-dichlorophenyl)-7-methylpyrido[2,3-d]pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 0.720nMAssay Description:Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KWKPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50220096(3-methoxy-5-(7-methylpyrido[2,3-d]pyrimidin-2-yl)b...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KWKPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50220088(3-methoxy-5-(pyrido[2,3-d]pyrimidin-2-yl)benzonitr...)copy SMILEScopy InChI
Affinity DataIC50: 4.95nMAssay Description:Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KWKPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224920(3-methoxy-5-(2-methyl-1,6-naphthyridin-7-yl)benzon...)copy SMILEScopy InChI
Affinity DataIC50: 6.19nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50220085(2-(3-bromophenyl)-7-methylpyrido[2,3-d]pyrimidine ...)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KWKPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50220076(2-(3-fluoro-5-methylphenyl)-7-methylpyrido[2,3-d]p...)copy SMILEScopy InChI
Affinity DataIC50: 39.7nMAssay Description:Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KWKPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224924(2-(3,4-dimethylphenyl)-1,8-naphthyridine | CHEMBL2...)copy SMILEScopy InChI
Affinity DataIC50: 45nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224929(2-(3-bromophenyl)-7-methyl-1,8-naphthyridine | CHE...)copy SMILEScopy InChI
Affinity DataIC50: 47.9nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224922(2-(3,5-dimethoxyphenyl)-7-methyl-1,8-naphthyridine...)copy SMILEScopy InChI
Affinity DataIC50: 51.7nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50220084(7-methyl-2-m-tolylpyrido[2,3-d]pyrimidine | CHEMBL...)copy SMILEScopy InChI
Affinity DataIC50: 53nMAssay Description:Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KWKPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224932(3-methoxy-5-(1,5-naphthyridin-3-yl)benzonitrile | ...)copy SMILEScopy InChI
Affinity DataIC50: 55nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224941(2-(3,5-dimethoxyphenyl)-1,8-naphthyridine | CHEMBL...)copy SMILEScopy InChI
Affinity DataIC50: 67nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224940(3-methoxy-5-(1,6-naphthyridin-7-yl)benzonitrile | ...)copy SMILEScopy InChI
Affinity DataIC50: 68nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224923(3-(1,8-naphthyridin-2-yl)benzonitrile | CHEMBL2353...)copy SMILEScopy InChI
Affinity DataIC50: 115nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224936(2-(3-chlorophenyl)-7-methyl-1,8-naphthyridine | CH...)copy SMILEScopy InChI
Affinity DataIC50: 177nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50220079(2-(3,5-dimethoxyphenyl)-7-methylpyrido[2,3-d]pyrim...)copy SMILEScopy InChI
Affinity DataIC50: 179nMAssay Description:Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KWKPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224925(2-(3,5-difluorophenyl)-7-methyl-1,8-naphthyridine ...)copy SMILEScopy InChI
Affinity DataIC50: 181nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224917(2-m-tolyl-1,8-naphthyridine | CHEMBL395902)copy SMILEScopy InChI
Affinity DataIC50: 225nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50220077(2-(3,5-dichlorophenyl)pyrido[2,3-d]pyrimidine | CH...)copy SMILEScopy InChI
Affinity DataIC50: 228nMAssay Description:Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KWKPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50220094(3-(7-methylpyrido[2,3-d]pyrimidin-2-yl)benzonitril...)copy SMILEScopy InChI
Affinity DataIC50: 240nMAssay Description:Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KWKPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224939(2-methyl-7-m-tolyl-1,8-naphthyridine | CHEMBL23562...)copy SMILEScopy InChI
Affinity DataIC50: 277nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50220082(2-(3-fluoro-5-methylphenyl)pyrido[2,3-d]pyrimidine...)copy SMILEScopy InChI
Affinity DataIC50: 321nMAssay Description:Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KWKPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50220083(2-(3-bromophenyl)pyrido[2,3-d]pyrimidine | CHEMBL2...)copy SMILEScopy InChI
Affinity DataIC50: 333nMAssay Description:Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KWKPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224926(7-(3,5-dimethoxyphenyl)-2-methyl-1,6-naphthyridine...)copy SMILEScopy InChI
Affinity DataIC50: 345nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224921(3-(methoxymethoxy)-5-(1,6-naphthyridin-7-yl)benzon...)copy SMILEScopy InChI
Affinity DataIC50: 468nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224931(3-(7-methyl-1,8-naphthyridin-2-yl)benzonitrile | C...)copy SMILEScopy InChI
Affinity DataIC50: 480nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50090686(2-Methyl-7-phenyl-[1,8]naphthyridine | 2-methyl-7-...)copy SMILEScopy InChI
Affinity DataIC50: 664nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224938(2-methyl-7-m-tolyl-1,6-naphthyridine | CHEMBL23643...)copy SMILEScopy InChI
Affinity DataIC50: 676nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224930(7-m-tolyl-1,6-naphthyridine | CHEMBL238388)copy SMILEScopy InChI
Affinity DataIC50: 1.27E+3nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50220081(2-(3-methoxyphenyl)-7-methylpyrido[2,3-d]pyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KWKPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224933(3-fluoro-5-(1,6-naphthyridin-7-yl)benzonitrile | C...)copy SMILEScopy InChI
Affinity DataIC50: 1.59E+3nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224918(2-phenyl-1,8-naphthyridine | CHEMBL235396)copy SMILEScopy InChI
Affinity DataIC50: 1.84E+3nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50220097(7-methyl-2-phenylpyrido[2,3-d]pyrimidine | CHEMBL3...)copy SMILEScopy InChI
Affinity DataIC50: 2.70E+3nMAssay Description:Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KWKPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224943(7-(3-fluoro-5-methylphenyl)-2-methyl-1,6-naphthyri...)copy SMILEScopy InChI
Affinity DataIC50: 2.93E+3nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224927(7-(3,5-dimethoxyphenyl)-1,6-naphthyridine | CHEMBL...)copy SMILEScopy InChI
Affinity DataIC50: 6.07E+3nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224937(7-(3-fluoro-5-methylphenyl)-1,6-naphthyridine | CH...)copy SMILEScopy InChI
Affinity DataIC50: 6.57E+3nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224944(7-(3-methoxyphenyl)-2-methyl-1,6-naphthyridine | C...)copy SMILEScopy InChI
Affinity DataIC50: 7.90E+3nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224945(3-(3,4-dimethylphenyl)-1,5-naphthyridine | CHEMBL2...)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+4nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224919(3-m-tolyl-1,5-naphthyridine | CHEMBL236263)copy SMILEScopy InChI
Affinity DataIC50: 1.57E+4nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224942(3-(1,5-naphthyridin-3-yl)benzonitrile | CHEMBL3947...)copy SMILEScopy InChI
Affinity DataIC50: 1.86E+4nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50220098(3-(pyrido[2,3-d]pyrimidin-2-yl)benzonitrile | CHEM...)copy SMILEScopy InChI
Affinity DataIC50: 2.61E+4nMAssay Description:Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KWKPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50224934(2-methyl-7-phenyl-1,6-naphthyridine | CHEMBL236429)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TXSPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50220089(7-methyl-2-(3-(methylsulfonyl)phenyl)pyrido[2,3-d]...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KWKPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50220091(2-(2,4-dichlorophenyl)-7-methylpyrido[2,3-d]pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KWKPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50220095(2-(2-methoxyphenyl)-7-methylpyrido[2,3-d]pyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KWKPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50220090(2-(3,4-dichlorophenyl)-7-methylpyrido[2,3-d]pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KWKPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50220093(2-(4-bromophenyl)-7-methylpyrido[2,3-d]pyrimidine ...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KWKPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50220092(CHEMBL238554 | methyl 4-(7-methylpyrido[2,3-d]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KWKPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50220080((3-(7-methylpyrido[2,3-d]pyrimidin-2-yl)phenyl)met...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KWKPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50220078(7-methyl-2-(3,4,5-trimethoxyphenyl)pyrido[2,3-d]py...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3KWKPubMed
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