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Found 667 with Last Name = 'antoni' and Initial = 'l'
TargetAdenosine deaminase(Bos taurus (bovine))
Universita di Pisa

LigandPNGBDBM28388(3-[4-({4-oxo-2H,4H,5H-pyrazolo[3,4-d]pyrimidin-2-y...)copy SMILEScopy InChI
Affinity DataKi:  160nM ΔG°:  -39.4kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K48J8PubMed
TargetAminopeptidase N(Homo sapiens (Human))
Monash University

Curated by ChEMBL
LigandPNGBDBM50518449(CHEMBL4435950)copy SMILEScopy InChI
Affinity DataKi:  300nMAssay Description:Inhibition of human APN expressed in HEK293 cells preincubated for 20 mins followed by L-leucine-7-amido-4-methylcoumarin addition by fluorescence as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0KJWPubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universita di Pisa

LigandPNGBDBM28383(N-[4-({4-oxo-2H,4H,5H-pyrazolo[3,4-d]pyrimidin-2-y...)copy SMILEScopy InChI
Affinity DataKi:  510nM ΔG°:  -36.5kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K48J8PubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universita di Pisa

LigandPNGBDBM28382(4-fluoro-N-[4-({4-oxo-2H,4H,5H-pyrazolo[3,4-d]pyri...)copy SMILEScopy InChI
Affinity DataKi:  960nM ΔG°:  -34.9kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K48J8PubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universita di Pisa

LigandPNGBDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)copy SMILEScopy InChI
Affinity DataKi:  1.14E+3nM ΔG°:  -34.5kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
TargetAdenosine deaminase(Bos taurus (bovine))
Universita di Pisa

LigandPNGBDBM28387(1-(4-fluorophenyl)-3-[4-({4-oxo-2H,4H,5H-pyrazolo[...)copy SMILEScopy InChI
Affinity DataKi:  1.15E+3nM ΔG°:  -34.5kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K48J8PubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universita di Pisa

LigandPNGBDBM28389(1-[4-(dimethylamino)phenyl]-3-[4-({4-oxo-2H,4H,5H-...)copy SMILEScopy InChI
Affinity DataKi:  2.01E+3nM ΔG°:  -33.1kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K48J8PubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universita di Pisa

LigandPNGBDBM28385(3-[4-({4-oxo-2H,4H,5H-pyrazolo[3,4-d]pyrimidin-2-y...)copy SMILEScopy InChI
Affinity DataKi:  2.42E+3nM ΔG°:  -32.6kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K48J8PubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universita di Pisa

LigandPNGBDBM28380(N-[4-({4-oxo-2H,4H,5H-pyrazolo[3,4-d]pyrimidin-2-y...)copy SMILEScopy InChI
Affinity DataKi:  1.27E+4nM ΔG°:  -28.4kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K48J8PubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universita di Pisa

LigandPNGBDBM28381(4-methoxy-N-[4-({4-oxo-2H,4H,5H-pyrazolo[3,4-d]pyr...)copy SMILEScopy InChI
Affinity DataKi:  1.56E+4nM ΔG°:  -27.9kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K48J8PubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universita di Pisa

LigandPNGBDBM28386(1-(4-methoxyphenyl)-3-[4-({4-oxo-2H,4H,5H-pyrazolo...)copy SMILEScopy InChI
Affinity DataKi:  2.83E+4nM ΔG°:  -26.4kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K48J8PubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universita di Pisa

LigandPNGBDBM28384(N-[4-({4-oxo-2H,4H,5H-pyrazolo[3,4-d]pyrimidin-2-y...)copy SMILEScopy InChI
Affinity DataKi:  4.79E+4nM ΔG°:  -25.1kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K48J8PubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universita di Pisa

LigandPNGBDBM28392(1-benzyl-3-[4-({4-oxo-2H,4H,5H-pyrazolo[3,4-d]pyri...)copy SMILEScopy InChI
Affinity DataKi:  8.57E+4nM ΔG°:  -23.6kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K48J8PubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universita di Pisa

LigandPNGBDBM28391(1-[4-(benzyloxy)phenyl]-3-[4-({4-oxo-2H,4H,5H-pyra...)copy SMILEScopy InChI
Affinity DataKi:  1.08E+5nM ΔG°:  -23.0kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K48J8PubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universita di Pisa

LigandPNGBDBM28390(1-(4-benzylphenyl)-3-[4-({4-oxo-2H,4H,5H-pyrazolo[...)copy SMILEScopy InChI
Affinity DataKi:  1.86E+5nM ΔG°:  -21.6kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29K48J8PubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50593468(CHEMBL5199803)copy SMILES
Affinity DataIC50: 0.190nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K0788FPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50593464(CHEMBL5184399)copy SMILES
Affinity DataIC50: 0.260nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K0788FPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50593462(CHEMBL5178058)copy SMILES
Affinity DataIC50: 0.330nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K0788FPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50593471(CHEMBL5195371)copy SMILES
Affinity DataIC50: 0.390nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K0788FPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Monash University

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)copy SMILEScopy InChI
Affinity DataIC50: 0.430nMAssay Description:Inhibition of MMP2 (unknown origin) preincubated for 1 hr followed by (QF)-24 substrate addition measured at 1 min time interval for 1 hr by fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0KJWPubMedDrugBank
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50593476(CHEMBL5191405)copy SMILES
Affinity DataIC50: 0.670nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K0788FPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50593472(CHEMBL5174813)copy SMILES
Affinity DataIC50: 0.710nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K0788FPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)copy SMILEScopy InChI
Affinity DataIC50: 0.740nMMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50593473(CHEMBL5207726)copy SMILES
Affinity DataIC50: 0.75nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K0788FPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50593466(CHEMBL5187253)copy SMILES
Affinity DataIC50: 0.760nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K0788FPubMed
LigandPNGBDBM534094(WO2022081807, Example 201)copy SMILES
Affinity DataIC50: 0.810nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20868HPPubMed
TargetEstrogen receptor beta(Homo sapiens (Human))TBA
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)copy SMILEScopy InChI
Affinity DataIC50: 0.890nMMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)copy SMILEScopy InChI
Affinity DataIC50: 0.890nMMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50593475(CHEMBL5178110)copy SMILES
Affinity DataIC50: 1.10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K0788FPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50593474(CHEMBL5203282)copy SMILES
Affinity DataIC50: 1.10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K0788FPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50180684(4-OHT | Afimoxifene | TamoGel)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K0788FPubMed
LigandPNGBDBM533971(WO2022081807, Example 78)copy SMILES
Affinity DataIC50: 1.41nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20868HPPubMed
LigandPNGBDBM533872(WO2022081807, Example 5)copy SMILES
Affinity DataIC50: 1.42nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20868HPPubMed
LigandPNGBDBM534119(WO2022081807, Example 226)copy SMILES
Affinity DataIC50: 1.79nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20868HPPubMed
LigandPNGBDBM534154(6-Cyclopropyl-N-(2-ethoxy-5-sec-butyl-phenyl)sulfo...)copy SMILES
Affinity DataIC50: 1.84nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VM4GFQPubMed
LigandPNGBDBM534100(WO2022081807, Example 207)copy SMILES
Affinity DataIC50: 1.86nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20868HPPubMed
LigandPNGBDBM534192(N-[(2-Cyclobutoxy-5-isopropylphenyl)sulfonyl]-6-cy...)copy SMILES
Affinity DataIC50: 2.09nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VM4GFQPubMed
LigandPNGBDBM534190(N-((5-(tert-Butyl)-2-cyclobutoxyphenyl)sulfonyl)-6...)copy SMILES
Affinity DataIC50: 2.46nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VM4GFQPubMed
LigandPNGBDBM534121(WO2022081807, Example 228)copy SMILES
Affinity DataIC50: 2.57nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20868HPPubMed
LigandPNGBDBM534187(N-[(2-(Benzyloxy)-5-(tert-butyl)phenyl)sulfonyl]-6...)copy SMILES
Affinity DataIC50: 2.67nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VM4GFQPubMed
LigandPNGBDBM534188(N-((5-(tert-butyl)-2-(cyclopropylmethoxy)phenyl)su...)copy SMILES
Affinity DataIC50: 2.92nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VM4GFQPubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50335684(4-FLUORO-2-(4-{[(3S,4R)-4-(1-HYDROXY-1-METHYLETHYL...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of CHK2 by DELFIA assayMore data for this Ligand-Target Pair
LigandPNGBDBM534161(6-Cyclopropyl-N-[2-(cyclopropylmethoxy)-5-isopropy...)copy SMILES
Affinity DataIC50: 3.01nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VM4GFQPubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Monash University

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMAssay Description:Inhibition of MMP9 (unknown origin) preincubated for 1 hr followed by (QF)-24 substrate addition measured at 1 min time interval for 1 hr by fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0KJWPubMedDrugBank
LigandPNGBDBM534193(N-((5-(tert-butyl)-2-methoxyphenyl)sulfonyl)-6-cyc...)copy SMILES
Affinity DataIC50: 3.31nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VM4GFQPubMed
LigandPNGBDBM534186(N-((5-(tert-butyl)-2-cyclopropoxyphenyl)sulfonyl)-...)copy SMILES
Affinity DataIC50: 3.58nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VM4GFQPubMed
TargetEstrogen receptor beta(Homo sapiens (Human))TBA
LigandPNGBDBM50180684(4-OHT | Afimoxifene | TamoGel)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K0788FPubMed
LigandPNGBDBM534118(6-(Azetidin-1-yl)-N-[(2-(benzyloxy)-5-(tert-butyl)...)copy SMILES
Affinity DataIC50: 3.72nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20868HPPubMed
LigandPNGBDBM534117(WO2022081807, Example 224)copy SMILES
Affinity DataIC50: 3.72nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20868HPPubMed
LigandPNGBDBM534107(6-(azetidin-1-yl)-N-[2-(cyclopropylmethoxy)-5-isop...)copy SMILES
Affinity DataIC50: 3.91nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20868HPPubMed
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