Compile Data Set for Download or QSAR
Found 437 with Last Name = 'bratton' and Initial = 'l'
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50215692(CHEMBL400874 | sodium (3R,5R)-7-(5-((4-cyanobenzyl...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1K9QPubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50001450((SP)Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH...)copy SMILEScopy InChI
Affinity DataIC50: 0.240nMAssay Description:Compound was evaluated for the antagonistic activity against NK1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1RJ0
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50215693(CHEMBL437774 | sodium (3R,5R)-7-(5-((4-carboxyphen...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1K9QPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50215689(CHEMBL250317 | sodium (3R,5R)-7-(5-((4-carbamoylph...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1K9QPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50215688(CHEMBL399773 | sodium (3R,5R)-7-(5-((3-(dimethylca...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1K9QPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50215700(CHEMBL400973 | sodium (3R,5R)-7-(3-(4-fluorophenyl...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1K9QPubMed
TargetSubstance-P receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50000040(((2S,3S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...)copy SMILEScopy InChI
Affinity DataIC50: 0.560nMAssay Description:Antagonism of the guinea pig tachykinin NK1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1RJ0
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50215704(CHEMBL398551 | sodium (3R,5R)-7-(5-(((1,5-dimethyl...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1K9QPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50215699(CHEMBL400747 | sodium (3R,5R)-7-(3,4-bis(4-fluorop...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1K9QPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50215707(CHEMBL250749 | sodium (3R,5R)-7-(5-((4-(methoxymet...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1K9QPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50215684(CHEMBL398240 | sodium (3R,5R)-7-(3-(4-fluorophenyl...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1K9QPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50215708(CHEMBL249724 | sodium (3R,5R)-7-(5-((4-methoxybenz...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1K9QPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50215690(CHEMBL399313 | sodium (3R,5R)-7-(5-(benzylcarbamoy...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1K9QPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM18382(Alkyl substituted pyrrole compound, 29f | disodium...)copy SMILEScopy InChI
Affinity DataIC50: 0.850nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3B7GPubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50382321(CHEMBL2024688)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04H9PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50382322(CHEMBL2024689)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04H9PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50215694(CHEMBL249906 | sodium (3R,5R)-7-(5-((3-carbamoylbe...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1K9QPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50215698(CHEMBL251499 | sodium (3R,5R)-7-(5-((4-(dimethylca...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1K9QPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50215683(CHEMBL403127 | sodium (3R,5R)-7-(5-((4-(dimethylca...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1K9QPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50215691(CHEMBL398239 | sodium (3R,5R)-7-(3-(4-fluorophenyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1K9QPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM18387(Alkyl substituted pyrrole compound, 29d | sodium (...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3B7GPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM18384(Alkyl substituted pyrrole compound, 29c | sodium (...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3B7GPubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50212698(2-(7-(2-(4-(trifluoromethyl)benzyloxy)-5-fluoroben...)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Displacement of [3H]2-(4-(3-(4-acetyl-3-hydroxy-2 propyl-phenoxy)propoxy)phenoxy)acetic acid from human PPARdelta after 30 mins by SPA assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S1826NPubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50212693(2-(4-(4-(4-(trifluoromethyl)benzyloxy)benzylthio)-...)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Displacement of [3H]2-(4-(3-(4-acetyl-3-hydroxy-2 propyl-phenoxy)propoxy)phenoxy)acetic acid from human PPARdelta after 30 mins by SPA assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S1826NPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM18374(CHEMBL394937 | Pyrrole-based compound, 30 | sodium...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1K9QPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50215706(CHEMBL399315 | sodium (3R,5R)-7-(5-((3-methoxybenz...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1K9QPubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50382324(CHEMBL2024691)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04H9PubMed
TargetSubstance-K receptor(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50290298((1-{2-[(R)-3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimet...)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154H1T
TargetSubstance-K receptor(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50290306((1-{2-[(R)-3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimet...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154H1T
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50215686(CHEMBL401293 | sodium (3R,5R)-7-(5-((4-carboxybenz...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1K9QPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM18381(Pyridyl substituted pyrrole compound, 14 | sodium ...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3B7GPubMed
TargetSubstance-P receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50290313((1'-{2-[(R)-3-(3,4-Dichloro-phenyl)-1-(3,4,5-trime...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154H1T
TargetSubstance-P receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50290302(1-{2-[(R)-3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimeth...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154H1T
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50215696(CHEMBL400560 | sodium (3R,5R)-7-(3-(4-fluorophenyl...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1K9QPubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM28661(2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Displacement of [3H]2-(4-(3-(4-acetyl-3-hydroxy-2 propyl-phenoxy)propoxy)phenoxy)acetic acid from human PPARdelta after 30 mins by SPAMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50213331(2-(5-((4-methyl-2-(trifluoromethyl)thiazol-5-yl)me...)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMAssay Description:Displacement of [3H]2-(4-(3-(4-acetyl-3-hydroxy-2 propyl-phenoxy)propoxy)phenoxy)acetic acid from human PPARdelta after 30 mins by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GBBPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM18376((3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)...)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM18386(Alkyl substituted pyrrole compound, 29b | sodium (...)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3B7GPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50215680(CHEMBL250953 | sodium (3R,5R)-7-[3-(4-fluoro-pheny...)copy SMILEScopy InChI
Affinity DataIC50: 2.90nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1K9QPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50215687(CHEMBL438694 | sodium (3R,5R)-7-(5-carbamoyl-3-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1K9QPubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50175494(1-{2-[(R)-3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimeth...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Compound was evaluated for the antagonistic activity against NK1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1RJ0
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50382320(CHEMBL2024687)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04H9PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM18372((3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethan...)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
TargetSubstance-K receptor(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50290303((1-{2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy...)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMAssay Description:Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154H1T
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50213326(2-(6-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiaz...)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMAssay Description:Displacement of [3H]2-(4-(3-(4-acetyl-3-hydroxy-2 propyl-phenoxy)propoxy)phenoxy)acetic acid from human PPARdelta after 30 mins by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GBBPubMed
TargetSubstance-P receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50290297(1-{2-[(R)-3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimeth...)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMAssay Description:Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154H1T
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Pfizer Global Research & Development

Curated by ChEMBL
LigandPNGBDBM50215685(CHEMBL249273 | sodium (3R,5R)-7-(3-(4-fluorophenyl...)copy SMILEScopy InChI
Affinity DataIC50: 3.40nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1K9QPubMed
TargetSubstance-K receptor(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50290312((1-{2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMAssay Description:Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154H1T
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50213330(2-(6-(4-((4-(trifluoromethyl)phenoxy)methyl)benzyl...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMAssay Description:Displacement of [3H]2-(4-(3-(4-acetyl-3-hydroxy-2 propyl-phenoxy)propoxy)phenoxy)acetic acid from human PPARdelta after 30 mins by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GBBPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM18372((3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethan...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
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