Compile Data Set for Download or QSAR
Found 358 with Last Name = 'honigberg' and Initial = 'l'
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Pharmacyclics, Inc.

US Patent
LigandPNGBDBM1773(US10280174, Comparative Compound 1 | US8476284, 4 ...)copy SMILEScopy InChI
Affinity DataKi:  14nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CJ8C3GUS Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Pharmacyclics, Inc.

US Patent
LigandPNGBDBM1773(US10280174, Comparative Compound 1 | US8476284, 4 ...)copy SMILEScopy InChI
Affinity DataKi:  97nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CJ8C3GUS Patent
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
PHARMACYCLICS LLC

US Patent
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765D5ZUS Patent
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
PHARMACYCLICS LLC

US Patent
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4TMXUS Patent
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM97672(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4TMXUS Patent
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM97672(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765D5ZUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM191606(US9181263, 23 | US9278100, 23)copy SMILEScopy InChI
Affinity DataIC50: 0.320nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4TMXUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM191606(US9181263, 23 | US9278100, 23)copy SMILEScopy InChI
Affinity DataIC50: 0.320nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765D5ZUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM191605(US9181263, 14 | US9278100, 14)copy SMILEScopy InChI
Affinity DataIC50: 0.390nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765D5ZUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM191605(US9181263, 14 | US9278100, 14)copy SMILEScopy InChI
Affinity DataIC50: 0.390nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4TMXUS Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM97672(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4TMXUS Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM97672(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765D5ZUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765D5ZUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM1774(US10894048, Ref. Ex Comp. 1 | US8476284, 13)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CJ8C3GUS Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4TMXUS Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM1773(US10280174, Comparative Compound 1 | US8476284, 4 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM1773(US10280174, Comparative Compound 1 | US8476284, 4 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM97673(US8476284, 41 | US8497277, 6)copy SMILEScopy InChI
Affinity DataIC50: 0.520nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CJ8C3GUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM181017(US9133201, 6)copy SMILEScopy InChI
Affinity DataIC50: 0.520nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WQ02KCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM97673(US8476284, 41 | US8497277, 6)copy SMILEScopy InChI
Affinity DataIC50: 0.520nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MW2FR5US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM97672(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)copy SMILEScopy InChI
Affinity DataIC50: 0.580nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WQ02KCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM97677(US8476284, 7 | US8497277, 7 | US9133201, 7)copy SMILEScopy InChI
Affinity DataIC50: 0.580nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WQ02KCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM97672(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)copy SMILEScopy InChI
Affinity DataIC50: 0.580nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CJ8C3GUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM97677(US8476284, 7 | US8497277, 7 | US9133201, 7)copy SMILEScopy InChI
Affinity DataIC50: 0.580nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CJ8C3GUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM97678(US8476284, 9 | US8497277, 10 | US8497277, 9 | US91...)copy SMILEScopy InChI
Affinity DataIC50: 0.580nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MW2FR5US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM97677(US8476284, 7 | US8497277, 7 | US9133201, 7)copy SMILEScopy InChI
Affinity DataIC50: 0.580nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MW2FR5US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM191617(US9181263, 13 | US9278100, 13)copy SMILEScopy InChI
Affinity DataIC50: 0.670nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765D5ZUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM191617(US9181263, 13 | US9278100, 13)copy SMILEScopy InChI
Affinity DataIC50: 0.670nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4TMXUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM1773(US10280174, Comparative Compound 1 | US8476284, 4 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.720nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM97674(US8476284, 42 | US8497277, 8 | US9133201, 8)copy SMILEScopy InChI
Affinity DataIC50: 0.720nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CJ8C3GUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM1773(US10280174, Comparative Compound 1 | US8476284, 4 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.720nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM97674(US8476284, 42 | US8497277, 8 | US9133201, 8)copy SMILEScopy InChI
Affinity DataIC50: 0.720nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WQ02KCUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM97674(US8476284, 42 | US8497277, 8 | US9133201, 8)copy SMILEScopy InChI
Affinity DataIC50: 0.720nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MW2FR5US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM1773(US10280174, Comparative Compound 1 | US8476284, 4 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.720nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Pharmacyclics, Inc.

US Patent
LigandPNGBDBM220129(US9278100, 18)copy SMILEScopy InChI
Affinity DataIC50: 0.760nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4TMXUS Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Pharmacyclics, Inc.

US Patent
LigandPNGBDBM191622(US9181263, 18)copy SMILEScopy InChI
Affinity DataIC50: 0.760nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765D5ZUS Patent
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4TMXUS Patent
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
PHARMACYCLICS LLC

US Patent
LigandPNGBDBM97672(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765D5ZUS Patent
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
PHARMACYCLICS LLC

US Patent
LigandPNGBDBM97672(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4TMXUS Patent
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765D5ZUS Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Pharmacyclics, Inc.

US Patent
LigandPNGBDBM191614(US9181263, 10 | US9278100, 10)copy SMILEScopy InChI
Affinity DataIC50: 0.880nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4TMXUS Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Pharmacyclics, Inc.

US Patent
LigandPNGBDBM191614(US9181263, 10 | US9278100, 10)copy SMILEScopy InChI
Affinity DataIC50: 0.880nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765D5ZUS Patent
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