TargetHistamine H3 receptor(Homo sapiens (Human))
Universit£ Bourgogne Franche-Comt£
Curated by ChEMBL
Universit£ Bourgogne Franche-Comt£
Curated by ChEMBL
Affinity DataKi: 0.5nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human H3 receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation countin...More data for this Ligand-Target Pair
TargetHistamine H3 receptor(Homo sapiens (Human))
Universit£ Bourgogne Franche-Comt£
Curated by ChEMBL
Universit£ Bourgogne Franche-Comt£
Curated by ChEMBL
Affinity DataKi: 40nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human H3 receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation countin...More data for this Ligand-Target Pair
TargetHistamine H3 receptor(Homo sapiens (Human))
Universit£ Bourgogne Franche-Comt£
Curated by ChEMBL
Universit£ Bourgogne Franche-Comt£
Curated by ChEMBL
Affinity DataKi: 60nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human H3 receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation countin...More data for this Ligand-Target Pair
TargetHistamine H3 receptor(Homo sapiens (Human))
Universit£ Bourgogne Franche-Comt£
Curated by ChEMBL
Universit£ Bourgogne Franche-Comt£
Curated by ChEMBL
Affinity DataKi: 83nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human H3 receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation countin...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Laboratory of Medicinal Chemistry (IQOG, CSIC)
Curated by ChEMBL
Laboratory of Medicinal Chemistry (IQOG, CSIC)
Curated by ChEMBL
Affinity DataKi: 147nMAssay Description:Non-competitive inhibition of recombinant human AChE expressed in HEK293 cells assessed as enzyme-substrate-inhibitor complex using varying levels of...More data for this Ligand-Target Pair
TargetHistamine H3 receptor(Homo sapiens (Human))
Universit£ Bourgogne Franche-Comt£
Curated by ChEMBL
Universit£ Bourgogne Franche-Comt£
Curated by ChEMBL
Affinity DataKi: 425nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human H3 receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation countin...More data for this Ligand-Target Pair
TargetHistamine H3 receptor(Homo sapiens (Human))
Universit£ Bourgogne Franche-Comt£
Curated by ChEMBL
Universit£ Bourgogne Franche-Comt£
Curated by ChEMBL
Affinity DataKi: 565nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human H3 receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation countin...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Laboratory of Medicinal Chemistry (IQOG, CSIC)
Curated by ChEMBL
Laboratory of Medicinal Chemistry (IQOG, CSIC)
Curated by ChEMBL
Affinity DataKi: 870nMAssay Description:Non-competitive inhibition of recombinant human AChE expressed in HEK293 cells using varying levels of acetylthiocholine iodide as substrate pretreat...More data for this Ligand-Target Pair
TargetHistamine H3 receptor(Homo sapiens (Human))
Universit£ Bourgogne Franche-Comt£
Curated by ChEMBL
Universit£ Bourgogne Franche-Comt£
Curated by ChEMBL
Affinity DataKi: 1.62E+3nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human H3 receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation countin...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Laboratory of Medicinal Chemistry (IQOG, CSIC)
Curated by ChEMBL
Laboratory of Medicinal Chemistry (IQOG, CSIC)
Curated by ChEMBL
Affinity DataKi: 3.88E+3nMAssay Description:Non-competitive inhibition of recombinant human AChE expressed in HEK293 cells assessed as enzyme-substrate-inhibitor complex using varying levels of...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of horse serum BuChE using butyrylthiocholine as substrate pretreated for 10 mins followed by substrate addition measured after 15 mins by...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universidade de Lisboa
Curated by ChEMBL
Universidade de Lisboa
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of electric eel AChE by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of horse serum BuChE pre-incubated for 10 mins before addition of butyrylthiocholine iodide substrate and further incubated for 15 mins by...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of horse serum BuChE pre-incubated for 10 mins before addition of butyrylthiocholine iodide substrate and further incubated for 15 mins by...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universidade de Lisboa
Curated by ChEMBL
Universidade de Lisboa
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Inhibition of rat MAO B using kynuramine as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Inhibition of horse serum BuChE pre-incubated for 10 mins before addition of butyrylthiocholine iodide substrate and further incubated for 15 mins by...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of horse serum BuChE pre-incubated for 10 mins before addition of butyrylthiocholine iodide substrate and further incubated for 15 mins by...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universidade de Lisboa
Curated by ChEMBL
Universidade de Lisboa
Curated by ChEMBL
Affinity DataIC50: 3.60nMAssay Description:Inhibition of Electrophorus electricus AChE pre-incubated for 10 mins before addition of acetylthiocholine iodide substrate and further incubated for...More data for this Ligand-Target Pair
Affinity DataIC50: 3.90nMAssay Description:Inhibition of horse serum BuChE pre-incubated for 10 mins before addition of butyrylthiocholine iodide substrate and further incubated for 15 mins by...More data for this Ligand-Target Pair
Affinity DataIC50: 5.10nMAssay Description:Inhibition of horse serum BuChE pre-incubated for 10 mins before addition of butyrylthiocholine iodide substrate and further incubated for 15 mins by...More data for this Ligand-Target Pair
Affinity DataIC50: 5.20nMAssay Description:Inhibition of horse serum BChE after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 5.40nMAssay Description:Inhibition of horse serum BuChE pre-incubated for 10 mins before addition of butyrylthiocholine iodide substrate and further incubated for 15 mins by...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Universidade de Lisboa
Curated by ChEMBL
Universidade de Lisboa
Curated by ChEMBL
Affinity DataIC50: 5.40nMAssay Description:Inhibition of human MAO AMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universidade de Lisboa
Curated by ChEMBL
Universidade de Lisboa
Curated by ChEMBL
Affinity DataIC50: 7.60nMAssay Description:Inhibition of Electrophorus electricus AChE pre-incubated for 10 mins before addition of acetylthiocholine iodide substrate and further incubated for...More data for this Ligand-Target Pair
Affinity DataIC50: 8.20nMAssay Description:Inhibition of horse serum BuChE pre-incubated for 10 mins before addition of butyrylthiocholine iodide substrate and further incubated for 15 mins by...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universidade de Lisboa
Curated by ChEMBL
Universidade de Lisboa
Curated by ChEMBL
Affinity DataIC50: 8.40nMAssay Description:Inhibition of Electrophorus electricus AChE pre-incubated for 10 mins before addition of acetylthiocholine iodide substrate and further incubated for...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Laboratory of Medicinal Chemistry (IQOG, CSIC)
Curated by ChEMBL
Laboratory of Medicinal Chemistry (IQOG, CSIC)
Curated by ChEMBL
Affinity DataIC50: 9.40nMAssay Description:Inhibition of human AChE using acetylthiocholine chloride as substrate peincubated for 15 mins followed by substrate addition measured at 1 min inter...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universidade de Lisboa
Curated by ChEMBL
Universidade de Lisboa
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride as substrate peincubated for 15 mins followed by substrate addition measured at 1 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of horse serum BuChE pre-incubated for 10 mins before addition of butyrylthiocholine iodide substrate and further incubated for 15 mins by...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universidade de Lisboa
Curated by ChEMBL
Universidade de Lisboa
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of Electrophorus electricus AChE pre-incubated for 10 mins before addition of acetylthiocholine iodide substrate and further incubated for...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universidade de Lisboa
Curated by ChEMBL
Universidade de Lisboa
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of Electrophorus electricus AChE pre-incubated for 10 mins before addition of acetylthiocholine iodide substrate and further incubated for...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universidade de Lisboa
Curated by ChEMBL
Universidade de Lisboa
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of Electrophorus electricus AChE pre-incubated for 10 mins before addition of acetylthiocholine iodide substrate and further incubated for...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universidade de Lisboa
Curated by ChEMBL
Universidade de Lisboa
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of Electrophorus electricus AChE pre-incubated for 10 mins before addition of acetylthiocholine iodide substrate and further incubated for...More data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
Universit£ Bourgogne Franche-Comt£
Curated by ChEMBL
Universit£ Bourgogne Franche-Comt£
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Antagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calciu...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of BuChE in human erythrocyte hemo-lyzates pre-incubated for 5 mins before addition of butyrylthiocholine iodide substrate by Ellman's met...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universidade de Lisboa
Curated by ChEMBL
Universidade de Lisboa
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride as substrate peincubated for 15 mins followed by substrate addition measured at 1 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of BuChE in human erythrocyte hemo-lyzates pre-incubated for 5 mins before addition of butyrylthiocholine iodide substrate by Ellman's met...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universidade de Lisboa
Curated by ChEMBL
Universidade de Lisboa
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of electric eel AChE after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universidade de Lisboa
Curated by ChEMBL
Universidade de Lisboa
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of Electrophorus electricus AChE pre-incubated for 10 mins before addition of acetylthiocholine iodide substrate and further incubated for...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universidade de Lisboa
Curated by ChEMBL
Universidade de Lisboa
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate pretreated for 10 mins followed by substrate addition measure...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Laboratory of Medicinal Chemistry (IQOG, CSIC)
Curated by ChEMBL
Laboratory of Medicinal Chemistry (IQOG, CSIC)
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine as substrate pretreated for 20 mins followed by substrate addi...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universidade de Lisboa
Curated by ChEMBL
Universidade de Lisboa
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate pretreated for 10 mins followed by substrate addition measure...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universidade de Lisboa
Curated by ChEMBL
Universidade de Lisboa
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate pretreated for 10 mins followed by substrate addition measure...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universidade de Lisboa
Curated by ChEMBL
Universidade de Lisboa
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate pretreated for 10 mins followed by substrate addition measure...More data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Inhibition of recombinant human serum BChE using butyrylthiocholine as substrate pretreated for 20 mins followed by substrate addition by Ellman's me...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Laboratory of Medicinal Chemistry (IQOG, CSIC)
Curated by ChEMBL
Laboratory of Medicinal Chemistry (IQOG, CSIC)
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Inhibition of AChE in human erythrocyte hemo-lyzates pre-incubated for 5 mins before addition of acetylthiocholine iodide substrate by Ellman's metho...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universidade de Lisboa
Curated by ChEMBL
Universidade de Lisboa
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Inhibition of Electrophorus electricus AChE pre-incubated for 10 mins before addition of acetylthiocholine iodide substrate and further incubated for...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universidade de Lisboa
Curated by ChEMBL
Universidade de Lisboa
Curated by ChEMBL
Affinity DataIC50: 51nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride as substrate peincubated for 15 mins followed by substrate addition measured at 1 mi...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Laboratory of Medicinal Chemistry (IQOG, CSIC)
Curated by ChEMBL
Laboratory of Medicinal Chemistry (IQOG, CSIC)
Curated by ChEMBL
Affinity DataIC50: 51nMAssay Description:Inhibition of human AChE using acetylthiocholine chloride as substrate peincubated for 15 mins followed by substrate addition measured at 1 min inter...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universidade de Lisboa
Curated by ChEMBL
Universidade de Lisboa
Curated by ChEMBL
Affinity DataIC50: 51nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride as substrate peincubated for 15 mins followed by substrate addition measured at 1 mi...More data for this Ligand-Target Pair
![](/img/powered_by_small.gif)