Compile Data Set for Download or QSAR
Found 280 with Last Name = 'jayaraman' and Initial = 'l'
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50258790((S)-2-amino-N-(3-(5-(5-(benzo[d]thiazol-7-yl)-1,3,...)copy SMILEScopy InChI
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of human CARM1 assessed as inhibition of histone3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G3WPubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50301077(2-(4-(2-(2,6-dimethoxyphenyl)-7-methyl-1H-benzo[d]...)copy SMILEScopy InChI
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of human CARM1 assessed as inhibition of histone3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G3WPubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50301079(2-(4-(2-(2-fluoro-6-methoxyphenyl)-7-methyl-1H-ben...)copy SMILEScopy InChI
Affinity DataIC50: 0.120nMAssay Description:Inhibition of human CARM1 assessed as inhibition of histone3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G3WPubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50301078(2-(4-(2-(4-fluoro-2-methoxyphenyl)-7-methyl-1H-ben...)copy SMILEScopy InChI
Affinity DataIC50: 0.260nMAssay Description:Inhibition of human CARM1 assessed as inhibition of histone3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G3WPubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50301076(2-(4-(2-(2-methoxyphenyl)-4-methyl-1H-benzo[d]imid...)copy SMILEScopy InChI
Affinity DataIC50: 0.410nMAssay Description:Inhibition of human CARM1 assessed as inhibition of histone3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G3WPubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50301075(2-(4-(2-(2-methoxypyridin-3-yl)-3H-imidazo[4,5-b]p...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human CARM1 assessed as inhibition of histone3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G3WPubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50301069(2-(4-(2-(2-methoxypyridin-3-yl)-4-methyl-1H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 0.840nMAssay Description:Inhibition of human CARM1 assessed as inhibition of histone3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G3WPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM144614(US8969586, 1 | US9598436, 1)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Binding affinity against Melatonin receptor using ovine pars tuberalis membranes of the pituitary.More data for this Ligand-Target Pair
In DepthDetails
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50301073(2-(4-(2-(2-methoxypyridin-3-yl)-1H-benzo[d]imidazo...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human CARM1 assessed as inhibition of histone3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G3WPubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614709(CHEMBL5273615)copy SMILES
Affinity DataIC50: 1.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Macaca fascicularis)TBA
LigandPNGBDBM50405216(CHEMBL5290029)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against cell free dihydrofolate reductase (DHFR) from ratMore data for this Ligand-Target Pair
In DepthDetails
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Macaca fascicularis)TBA
LigandPNGBDBM50405216(CHEMBL5290029)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against cell free dihydrofolate redutase (DHFR) from Mycobacterium lufuMore data for this Ligand-Target Pair
In DepthDetails
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50156232(CHEMBL3782020)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human CYP17A1 expressed in HEK293 cell microsomes using [3H]-pregnenolone as substrate incubated for 45 mins by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8PK5PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Macaca fascicularis)TBA
LigandPNGBDBM50156282(CHEMBL3780847)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of CYP17A1 in cynomolgus monkey using [3H]-pregnenolone as substrate incubated for 45 mins by scintillation proximity assay in presence of...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8PK5PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Macaca fascicularis)TBA
LigandPNGBDBM50391846(CHEMBL2147041 | US9133160, 31)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of CYP17A1 in cynomolgus monkey adrenal microsomes using [3H]-pregnenolone as substrate incubated for 45 mins by scintillation proximity a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8PK5PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50404835(CHEMBL5284599)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Binding affinity against Melatonin receptor using ovine pars tuberalis membranes of the pituitary.More data for this Ligand-Target Pair
In DepthDetails
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50301074(2-(4-(2-(2-methoxypyridin-3-yl)-1-methyl-1H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human CARM1 assessed as inhibition of histone3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G3WPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Macaca fascicularis)TBA
LigandPNGBDBM50156282(CHEMBL3780847)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of CYP17A1 in cynomolgus monkey adrenal microsomes using [3H]-pregnenolone as substrate incubated for 45 mins by scintillation proximity a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8PK5PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50404839(CHEMBL5286021)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Binding affinity against Melatonin receptor using ovine pars tuberalis membranes of the pituitary.More data for this Ligand-Target Pair
In DepthDetails
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50405184(CHEMBL5290743)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Binding affinity against Melatonin receptor using ovine pars tuberalis membranes of the pituitary.More data for this Ligand-Target Pair
In DepthDetails
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50156233(CHEMBL3780658)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human CYP17A1 expressed in HEK293 cell microsomes using [3H]-pregnenolone as substrate incubated for 45 mins by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8PK5PubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614704(CHEMBL5279540)copy SMILES
Affinity DataIC50: 3.40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614710(CHEMBL5267407)copy SMILES
Affinity DataIC50: 3.60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50156281(CHEMBL3780743)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human CYP17A1 expressed in HEK293 cell microsomes using [3H]-pregnenolone as substrate incubated for 45 mins by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8PK5PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50156235(CHEMBL3780266)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human CYP17A1 expressed in HEK293 cell microsomes using [3H]-pregnenolone as substrate incubated for 45 mins by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8PK5PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50405189(CHEMBL5284859)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Binding affinity by the displacement of [3H]NMS binding to muscarinic M1 receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50405217(CHEMBL5265986)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Binding affinity by the displacement of [3H]NMS binding to muscarinic M1 receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Macaca fascicularis)TBA
LigandPNGBDBM50391846(CHEMBL2147041 | US9133160, 31)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of CYP17A1 in cynomolgus monkey using [3H]-pregnenolone as substrate incubated for 45 mins by scintillation proximity assay in presence of...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8PK5PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50301080(CHEMBL567298 | N-methyl-2-(4-(7-methyl-2-phenyl-1H...)copy SMILEScopy InChI
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human CARM1 assessed as inhibition of histone3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G3WPubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614709(CHEMBL5273615)copy SMILES
Affinity DataIC50: 4.60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50405210(CHEMBL5269382)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Binding affinity by the displacement of [3H]NMS binding to A9 L cells transfected with muscarinic M1 receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50405215(CHEMBL5290106)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Binding affinity by the displacement of [3H]NMS binding to muscarinic M2 receptor of rat heartMore data for this Ligand-Target Pair
In DepthDetails
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50405225(CHEMBL5286147)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Binding affinity by the displacement of [3H]NMS binding to muscarinic M1 receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50156231(CHEMBL3781112)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human CYP17A1 expressed in HEK293 cell microsomes using [3H]-pregnenolone as substrate incubated for 45 mins by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8PK5PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50156234(CHEMBL3780226)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human CYP17A1 expressed in HEK293 cell microsomes using [3H]-pregnenolone as substrate incubated for 45 mins by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8PK5PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50156236(CHEMBL3780048)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human CYP17A1 expressed in HEK293 cell microsomes using [3H]-pregnenolone as substrate incubated for 45 mins by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8PK5PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50404834(CHEMBL5280658)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Binding affinity against Melatonin receptor using ovine pars tuberalis membranes of the pituitary.More data for this Ligand-Target Pair
In DepthDetails
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50404843(CHEMBL5284207)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Binding affinity against Melatonin receptor using ovine pars tuberalis membranes of the pituitary.More data for this Ligand-Target Pair
In DepthDetails
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614703(CHEMBL5269992)copy SMILES
Affinity DataIC50: 5.90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50391839(CHEMBL2147034 | US9133160, 2)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of human CYP17A1 expressed in HEK293 cell microsomes using [3H]-pregnenolone as substrate incubated for 45 mins by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8PK5PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50405188(CHEMBL5286511)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Binding affinity by the displacement of [3H]NMS binding to muscarinic M2 receptor of rat heartMore data for this Ligand-Target Pair
In DepthDetails
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Macaca fascicularis)TBA
LigandPNGBDBM50405216(CHEMBL5290029)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibitory activity against cell free dihydrofolate redutase (DHFR) from Mycobacterium lufuMore data for this Ligand-Target Pair
In DepthDetails
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614705(CHEMBL5287356)copy SMILES
Affinity DataIC50: 6.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50404833(CHEMBL5266728)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptor by displacement of radioligand [3H]GR-65630.More data for this Ligand-Target Pair
In DepthDetails
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50454785(CHEMBL4207581)copy SMILEScopy InChI
In DepthDetails
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50405218(CHEMBL5269068)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Binding affinity by the displacement of [3H]NMS binding to muscarinic M1 receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50156237(CHEMBL3781487)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of human CYP17A1 expressed in HEK293 cell microsomes using [3H]-pregnenolone as substrate incubated for 45 mins by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8PK5PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50404844(CHEMBL5290740)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Binding affinity against Melatonin receptor using ovine pars tuberalis membranes of the pituitary.More data for this Ligand-Target Pair
In DepthDetails
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50405216(CHEMBL5290029)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibitory activity against dihydropteroic acid synthase (SYN) from Plasmodium bergheiMore data for this Ligand-Target Pair
In DepthDetails
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50156238(CHEMBL3781910)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of human CYP17A1 expressed in HEK293 cell microsomes using [3H]-pregnenolone as substrate incubated for 45 mins by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8PK5PubMed
Displayed 1 to 50 (of 280 total ) | Next | Last >>
Jump to: