Compile Data Set for Download or QSAR
Found 412 with Last Name = 'de garavilla' and Initial = 'l'
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14073((2S)-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-carbamimi...)copy SMILEScopy InChI
Affinity DataKi:  0.000650nM ΔG°:  -72.4kJ/mole IC50: 4.5nMpH: 7.4 T: 2°CAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14065((2S)-1-[(2R)-2-amino-3-phenylpropanoyl]-N-[1-(1,3-...)copy SMILEScopy InChI
Affinity DataKi:  0.00550nM ΔG°:  -66.9kJ/mole IC50: 21nMpH: 7.4 T: 2°CAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14127(2-(5-carbamimidamido-2-{[(2S)-1-[(2R)-2-(methylami...)copy SMILEScopy InChI
Affinity DataKi:  0.00700nM IC50: 5nMAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14076((2S)-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-carbamimi...)copy SMILEScopy InChI
Affinity DataKi:  0.0180nM ΔG°:  -63.8kJ/mole IC50: 5.30nMpH: 7.4 T: 2°CAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14066((2S)-N-[1-(1,3-benzothiazol-2-yl)-5-carbamimidamid...)copy SMILEScopy InChI
Affinity DataKi:  0.120nM ΔG°:  -58.9kJ/mole IC50: 15nMpH: 7.4 T: 2°CAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14123((2S)-N-[5-carbamimidamido-1-(6-methoxy-1,3-benzoth...)copy SMILEScopy InChI
Affinity DataKi:  0.140nM IC50: 5nMAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14125((2S)-N-[5-carbamimidamido-1-(6-fluoro-1,3-benzothi...)copy SMILEScopy InChI
Affinity DataKi:  0.150nM IC50: 7.5nMAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14068((2S)-N-[1-(1,3-benzothiazol-2-yl)-5-carbamimidamid...)copy SMILEScopy InChI
Affinity DataKi:  0.180nM ΔG°:  -57.9kJ/mole IC50: 48nMpH: 7.4 T: 2°CAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14071((2S)-1-(2-amino-2-benzylpropanoyl)-N-[1-(1,3-benzo...)copy SMILEScopy InChI
Affinity DataKi:  0.200nM ΔG°:  -57.6kJ/mole IC50: 3.5nMpH: 7.4 T: 2°CAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14063((2S)-N-[1-(1,3-benzothiazol-2-yl)-5-carbamimidamid...)copy SMILEScopy InChI
Affinity DataKi:  0.200nM ΔG°:  -57.6kJ/mole IC50: 29nMpH: 7.4 T: 2°CAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14124((2S)-N-[5-carbamimidamido-1-(6-hydroxy-1,3-benzoth...)copy SMILEScopy InChI
Affinity DataKi:  0.230nM IC50: 3nMAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetSerine protease 1(Bos taurus (bovine))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14065((2S)-1-[(2R)-2-amino-3-phenylpropanoyl]-N-[1-(1,3-...)copy SMILEScopy InChI
Affinity DataKi:  0.300nMAssay Description:Trypsin-catalyzed hydrolysis rates were measured spectrophotometrically using bovine trypsin, a chromogenic substrate in aqueous buffer, and a microp...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetSerine protease 1(Bos taurus (bovine))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14127(2-(5-carbamimidamido-2-{[(2S)-1-[(2R)-2-(methylami...)copy SMILEScopy InChI
Affinity DataKi:  0.300nMAssay Description:Trypsin-catalyzed hydrolysis rates were measured spectrophotometrically using bovine trypsin, a chromogenic substrate in aqueous buffer, and a microp...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14086((2S)-N-[1-(1,3-benzothiazol-2-yl)-5-carbamimidamid...)copy SMILEScopy InChI
Affinity DataKi:  0.340nM IC50: 38nMAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14072(2-ketobenzothiazole 12 | 2-{[(2R)-1-[(2S)-2-{[1-(1...)copy SMILEScopy InChI
Affinity DataKi:  0.360nM ΔG°:  -56.1kJ/mole IC50: 29nMpH: 7.4 T: 2°CAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14126((2S)-N-{5-carbamimidamido-1-[6-(hydroxymethyl)-1,3...)copy SMILEScopy InChI
Affinity DataKi:  0.370nM IC50: 7nMAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14075((2S)-N-[1-(1,3-benzothiazol-2-yl)-5-carbamimidamid...)copy SMILEScopy InChI
Affinity DataKi:  0.460nM ΔG°:  -55.4kJ/mole IC50: 34nMpH: 7.4 T: 2°CAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14122((2S)-N-(5-carbamimidamido-1-oxo-1-{3-thia-5-azatri...)copy SMILEScopy InChI
Affinity DataKi:  0.580nM IC50: 60nMAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14139((2S)-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-carbamimi...)copy SMILEScopy InChI
Affinity DataKi:  0.780nM IC50: 110nMAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14092((2S)-N-[(2S)-1-(1,3-benzothiazol-2-yl)-3-(3-carbam...)copy SMILEScopy InChI
Affinity DataKi:  0.990nMAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14074((2S)-N-[1-(1,3-benzothiazol-2-yl)-5-carbamimidamid...)copy SMILEScopy InChI
Affinity DataKi:  1.10nM ΔG°:  -53.2kJ/mole IC50: 11nMpH: 7.4 T: 2°CAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetSerine protease 1(Bos taurus (bovine))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14117((2S)-N-[5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-y...)copy SMILEScopy InChI
Affinity DataKi:  1.20nMAssay Description:Trypsin-catalyzed hydrolysis rates were measured spectrophotometrically using bovine trypsin, a chromogenic substrate in aqueous buffer, and a microp...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetSerine protease 1(Bos taurus (bovine))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14076((2S)-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-carbamimi...)copy SMILEScopy InChI
Affinity DataKi:  1.20nMAssay Description:Trypsin-catalyzed hydrolysis rates were measured spectrophotometrically using bovine trypsin, a chromogenic substrate in aqueous buffer, and a microp...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14128(2-ketobenzothiazole 68 | methyl 2-(5-carbamimidami...)copy SMILEScopy InChI
Affinity DataKi:  1.30nM IC50: 38nMAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14137(2-ketobenzothiazole 75 | methyl (3S)-4-[(2S)-2-{[(...)copy SMILEScopy InChI
Affinity DataKi:  1.40nM IC50: 56nMAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50146293(5-Hydroxy-biphenyl-2-carboxylic acid [3-chloro-4-(...)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:Inhibition of [3H]AVP binding to recombinant human vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN679WPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14138((2S)-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-carbamimi...)copy SMILEScopy InChI
Affinity DataKi:  1.5nM IC50: 95nMAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetSerine protease 1(Bos taurus (bovine))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14085((2S)-N-[1-(1,3-benzothiazol-2-yl)-5-carbamimidamid...)copy SMILEScopy InChI
Affinity DataKi:  1.5nMAssay Description:Trypsin-catalyzed hydrolysis rates were measured spectrophotometrically using bovine trypsin, a chromogenic substrate in aqueous buffer, and a microp...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetSerine protease 1(Bos taurus (bovine))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14125((2S)-N-[5-carbamimidamido-1-(6-fluoro-1,3-benzothi...)copy SMILEScopy InChI
Affinity DataKi:  1.5nMAssay Description:Trypsin-catalyzed hydrolysis rates were measured spectrophotometrically using bovine trypsin, a chromogenic substrate in aqueous buffer, and a microp...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14094((2S)-N-[(2S)-1-(1,3-benzothiazol-2-yl)-3-[(3S)-1-c...)copy SMILEScopy InChI
Affinity DataKi:  1.60nM IC50: 51nMAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetSerine protease 1(Bos taurus (bovine))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14078((2S)-1-(2-amino-2,2-diphenylacetyl)-N-[1-(1,3-benz...)copy SMILEScopy InChI
Affinity DataKi:  1.80nMAssay Description:Trypsin-catalyzed hydrolysis rates were measured spectrophotometrically using bovine trypsin, a chromogenic substrate in aqueous buffer, and a microp...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetSerine protease 1(Bos taurus (bovine))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14092((2S)-N-[(2S)-1-(1,3-benzothiazol-2-yl)-3-(3-carbam...)copy SMILEScopy InChI
Affinity DataKi:  1.80nMAssay Description:Trypsin-catalyzed hydrolysis rates were measured spectrophotometrically using bovine trypsin, a chromogenic substrate in aqueous buffer, and a microp...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetSerine protease 1(Bos taurus (bovine))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14086((2S)-N-[1-(1,3-benzothiazol-2-yl)-5-carbamimidamid...)copy SMILEScopy InChI
Affinity DataKi:  1.80nMAssay Description:Trypsin-catalyzed hydrolysis rates were measured spectrophotometrically using bovine trypsin, a chromogenic substrate in aqueous buffer, and a microp...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50146309(5-Fluoro-biphenyl-2-carboxylic acid [3-chloro-4-((...)copy SMILEScopy InChI
Affinity DataKi:  1.90nMAssay Description:Inhibition of [3H]AVP binding to recombinant human vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN679WPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14129(2-[(2S)-5-carbamimidamido-2-{[(2S)-1-[(2R)-2-(meth...)copy SMILEScopy InChI
Affinity DataKi:  2nM IC50: 45nMAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50146309(5-Fluoro-biphenyl-2-carboxylic acid [3-chloro-4-((...)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Inhibition of 1 nM AVP-induced cAMP accumulation in cells expressing human vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN679WPubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50146304(3'-Methoxy-biphenyl-2-carboxylic acid [3-chloro-4-...)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Inhibition of 1 nM AVP-induced cAMP accumulation in cells expressing human vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN679WPubMed
TargetSerine protease 1(Bos taurus (bovine))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14079((2S)-N-[1-(1,3-benzothiazol-2-yl)-5-carbamimidamid...)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Trypsin-catalyzed hydrolysis rates were measured spectrophotometrically using bovine trypsin, a chromogenic substrate in aqueous buffer, and a microp...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetSerine protease 1(Bos taurus (bovine))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14123((2S)-N-[5-carbamimidamido-1-(6-methoxy-1,3-benzoth...)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Trypsin-catalyzed hydrolysis rates were measured spectrophotometrically using bovine trypsin, a chromogenic substrate in aqueous buffer, and a microp...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14078((2S)-1-(2-amino-2,2-diphenylacetyl)-N-[1-(1,3-benz...)copy SMILEScopy InChI
Affinity DataKi:  2.10nM ΔG°:  -51.5kJ/mole IC50: 15nMpH: 7.4 T: 2°CAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14117((2S)-N-[5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-y...)copy SMILEScopy InChI
Affinity DataKi:  2.10nM IC50: 19nMAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataKi:  2.30nMAssay Description:Inhibition of [3H]AVP binding to recombinant human vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN679WPubMed
TargetChymase(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50208224(2-(3-((1-(2-naphthoyl)piperidin-4-yl)(methyl)carba...)copy SMILEScopy InChI
Affinity DataKi:  2.30nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
TargetSerine protease 1(Bos taurus (bovine))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14069((2S)-N-[1-(1,3-benzothiazol-2-yl)-5-carbamimidamid...)copy SMILEScopy InChI
Affinity DataKi:  2.40nMAssay Description:Trypsin-catalyzed hydrolysis rates were measured spectrophotometrically using bovine trypsin, a chromogenic substrate in aqueous buffer, and a microp...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetSerine protease 1(Bos taurus (bovine))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14077((2S)-N-[1-(1,3-benzothiazol-2-yl)-5-carbamimidamid...)copy SMILEScopy InChI
Affinity DataKi:  2.60nMAssay Description:Trypsin-catalyzed hydrolysis rates were measured spectrophotometrically using bovine trypsin, a chromogenic substrate in aqueous buffer, and a microp...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetSerine protease 1(Bos taurus (bovine))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14129(2-[(2S)-5-carbamimidamido-2-{[(2S)-1-[(2R)-2-(meth...)copy SMILEScopy InChI
Affinity DataKi:  2.70nMAssay Description:Trypsin-catalyzed hydrolysis rates were measured spectrophotometrically using bovine trypsin, a chromogenic substrate in aqueous buffer, and a microp...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetSerine protease 1(Bos taurus (bovine))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14138((2S)-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-carbamimi...)copy SMILEScopy InChI
Affinity DataKi:  2.70nMAssay Description:Trypsin-catalyzed hydrolysis rates were measured spectrophotometrically using bovine trypsin, a chromogenic substrate in aqueous buffer, and a microp...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50146283(4'-Methoxy-biphenyl-2-carboxylic acid [3-chloro-4-...)copy SMILEScopy InChI
Affinity DataKi:  2.80nMAssay Description:Inhibition of [3H]AVP binding to recombinant human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN679WPubMed
TargetSerine protease 1(Bos taurus (bovine))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14139((2S)-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-carbamimi...)copy SMILEScopy InChI
Affinity DataKi:  2.90nMAssay Description:Trypsin-catalyzed hydrolysis rates were measured spectrophotometrically using bovine trypsin, a chromogenic substrate in aqueous buffer, and a microp...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0658XPubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50146283(4'-Methoxy-biphenyl-2-carboxylic acid [3-chloro-4-...)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Inhibition of 1 nM AVP-induced cAMP accumulation in cells expressing human vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN679WPubMed
Displayed 1 to 50 (of 412 total ) | Next | Last >>
Jump to: