Compile Data Set for Download or QSAR
Found 38 with Last Name = 'zhang' and Initial = 'll'
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308556(3-(4-(3-hydroxypropyl)piperazin-1-yl)-1-(2-propoxy...)copy SMILEScopy InChI
Affinity DataIC50: 0.180nMAssay Description:Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308557(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308563(3-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)-1-(...)copy SMILEScopy InChI
Affinity DataIC50: 0.210nMAssay Description:Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308558(3-(4-ethylpiperazin-1-yl)-1-(2-propoxyethyl)-7-(6-...)copy SMILEScopy InChI
Affinity DataIC50: 0.220nMAssay Description:Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308564((R)-3-(4-(2-hydroxypropyl)piperazin-1-yl)-1-(2-iso...)copy SMILEScopy InChI
Affinity DataIC50: 0.230nMAssay Description:Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300957(3-(2-aminoethylamino)-7-(6-methoxypyridin-3-yl)-1-...)copy SMILEScopy InChI
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308561((+/-)-3-(4-((2R,3R)-3-hydroxybutan-2-yl)piperazin-...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308553((S)-3-(4-(2-hydroxypropyl)piperazin-1-yl)-1-(2-iso...)copy SMILEScopy InChI
Affinity DataIC50: 0.310nMAssay Description:Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308562((+/-)-3-(4-((2S,3R)-3-hydroxybutan-2-yl)piperazin-...)copy SMILEScopy InChI
Affinity DataIC50: 0.330nMAssay Description:Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308555(3-(4-(2-hydroxyethyl)-1,4-diazepan-1-yl)-1-(2-isop...)copy SMILEScopy InChI
Affinity DataIC50: 0.720nMAssay Description:Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300958(3-(2-(2-hydroxyethylamino)ethylamino)-7-(6-methoxy...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308554(3-(4-(3-hydroxypropyl)-1,4-diazepan-1-yl)-1-(2-pro...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308559(3-((1R,4R)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-1-(...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308560(3-(2-(2-hydroxyethylamino)ethylamino)-1-(2-propoxy...)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetAurora kinase A(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50079534(CHEMBL3417325)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of Aurora A in human HeLa cells after 12 hrs by ELISA methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78GXSPubMed
TargetAurora kinase A(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50079535(CHEMBL3417327)copy SMILEScopy InChI
Affinity DataIC50: 43nMAssay Description:Inhibition of Aurora A in human HeLa cells after 12 hrs by ELISA methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78GXSPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308562((+/-)-3-(4-((2S,3R)-3-hydroxybutan-2-yl)piperazin-...)copy SMILEScopy InChI
Affinity DataIC50: 54nMAssay Description:Inhibition of human ERG by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308564((R)-3-(4-(2-hydroxypropyl)piperazin-1-yl)-1-(2-iso...)copy SMILEScopy InChI
Affinity DataIC50: 230nMAssay Description:Inhibition of human ERG by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetAurora kinase A(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)copy SMILEScopy InChI
Affinity DataIC50: 261nMAssay Description:Inhibition of Aurora A in human HeLa cells after 12 hrs by ELISA methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78GXSPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308558(3-(4-ethylpiperazin-1-yl)-1-(2-propoxyethyl)-7-(6-...)copy SMILEScopy InChI
Affinity DataIC50: 320nMAssay Description:Inhibition of human ERG by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetAurora kinase B(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50079535(CHEMBL3417327)copy SMILEScopy InChI
Affinity DataIC50: 395nMAssay Description:Inhibition of Aurora B in human HeLa cells after 12 hrs by ELISA methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78GXSPubMed
TargetAurora kinase B(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50079534(CHEMBL3417325)copy SMILEScopy InChI
Affinity DataIC50: 430nMAssay Description:Inhibition of Aurora B in human HeLa cells after 12 hrs by ELISA methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78GXSPubMed
TargetAurora kinase B(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)copy SMILEScopy InChI
Affinity DataIC50: 453nMAssay Description:Inhibition of Aurora B in human HeLa cells after 12 hrs by ELISA methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78GXSPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308560(3-(2-(2-hydroxyethylamino)ethylamino)-1-(2-propoxy...)copy SMILEScopy InChI
Affinity DataIC50: 670nMAssay Description:Inhibition of human ERG by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308557(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)copy SMILEScopy InChI
Affinity DataIC50: 1.79E+3nMAssay Description:Inhibition of human ERG by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308557(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE4BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308557(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE4AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308557(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE3BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308557(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE3AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308557(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE1CMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308557(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE1BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308557(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE1AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308557(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE4CMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308557(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308557(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308557(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50308557(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE7BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300958(3-(2-(2-hydroxyethylamino)ethylamino)-7-(6-methoxy...)copy SMILEScopy InChI
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human ERG by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed