Compile Data Set for Download or QSAR
Found 280 with Last Name = 'volak' and Initial = 'lp'
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397798(CHEMBL2177836)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of Akt1 (1 to 480) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397783(CHEMBL2177833)copy SMILEScopy InChI
Affinity DataIC50: 5.20nMAssay Description:Inhibition of Akt1 (1 to 480) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetGTPase KRas(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514386(CHEMBL4456801)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of KRAS in human MIAPaca2 cells assessed as decrease in EGF-stimulated ERK1/2 phosphorylation preincubated for 2 hrs followed by EGF stimu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ93Q2PubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397780(CHEMBL2177831)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of Akt1 (1 to 480) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetGTPase KRas(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514393(CHEMBL4539214)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of KRAS in human MIAPaca2 cells assessed as decrease in EGF-stimulated ERK1/2 phosphorylation preincubated for 2 hrs followed by EGF stimu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ93Q2PubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397800(CHEMBL2177817)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of Akt1 (1 to 480) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397794(CHEMBL2177827)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of Akt2 (1 to 481) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397782(CHEMBL2177834)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of Akt1 (1 to 480) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397796(CHEMBL2177828)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of Akt 1 in human A2780 cells assessed as phosphorylation of Akt at T308 after 2 hrs by Western Blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397794(CHEMBL2177827)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of Akt1 (1 to 480) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397796(CHEMBL2177828)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of Akt1 (1 to 480) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397798(CHEMBL2177836)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of Akt2 (1 to 481) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetGTPase KRas(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514400(CHEMBL4434842)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of GDP bound recombinant human His-tagged KRAS G12C/C118A mutant (1 to 169 residues) assessed as reduction in SOS1-mediated GDP/GTP nucleo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ93Q2PubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397790(CHEMBL2177819)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of Akt1 (1 to 480) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397793(CHEMBL2177835)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of Akt1 (1 to 480) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397796(CHEMBL2177828)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of Akt2 (1 to 481) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397792(CHEMBL2177829)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of Akt2 (1 to 481) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetGTPase KRas(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514379(CHEMBL4452137)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of GDP bound recombinant human His-tagged KRAS G12C/C118A mutant (1 to 169 residues) assessed as reduction in SOS1-mediated GDP/GTP nucleo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ93Q2PubMed
TargetGTPase KRas(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514400(CHEMBL4434842)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of KRAS in human MIAPaca2 cells assessed as decrease in EGF-stimulated ERK1/2 phosphorylation preincubated for 2 hrs followed by EGF stimu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ93Q2PubMed
TargetGTPase KRas(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514372(CHEMBL4464232)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of KRAS in human MIAPaca2 cells assessed as decrease in EGF-stimulated ERK1/2 phosphorylation preincubated for 2 hrs followed by EGF stimu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ93Q2PubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397783(CHEMBL2177833)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:Inhibition of Akt2 (1 to 481) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397798(CHEMBL2177836)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:Inhibition of Akt1 in human A2780 cells assessed as phosphorylation of Akt at S473 after 2 hrs by Western Blot analysisMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397799(CHEMBL2177825)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:Inhibition of Akt1 (1 to 480) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetGTPase KRas(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514379(CHEMBL4452137)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of KRAS in human MIAPaca2 cells assessed as decrease in EGF-stimulated ERK1/2 phosphorylation preincubated for 2 hrs followed by EGF stimu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ93Q2PubMed
TargetGTPase KRas(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514388(CHEMBL4449810)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of KRAS in human MIAPaca2 cells assessed as decrease in EGF-stimulated ERK1/2 phosphorylation preincubated for 2 hrs followed by EGF stimu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ93Q2PubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397788(CHEMBL2177818)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of Akt1 (1 to 480) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397787(CHEMBL2177832)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of Akt1 (1 to 480) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397780(CHEMBL2177831)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of Akt2 (1 to 481) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397798(CHEMBL2177836)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Inhibition of Akt 1 in human A2780 cells assessed as phosphorylation of Akt at T308 after 2 hrs by Western Blot analysisMore data for this Ligand-Target Pair
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397787(CHEMBL2177832)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Inhibition of Akt2 (1 to 481) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397779(CHEMBL2177830)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:Inhibition of Akt1 (1 to 480) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397787(CHEMBL2177832)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Inhibition of Akt1 in human A2780 cells assessed as phosphorylation of Akt at S473 after 2 hrs by Western Blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetGTPase KRas(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514370(CHEMBL4588277)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Inhibition of GDP bound recombinant human His-tagged KRAS G12C/C118A mutant (1 to 169 residues) assessed as reduction in SOS1-mediated GDP/GTP nucleo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ93Q2PubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397793(CHEMBL2177835)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of Akt2 (1 to 481) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetGTPase KRas(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514383(CHEMBL4554946)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:Inhibition of KRAS in human MIAPaca2 cells assessed as decrease in EGF-stimulated ERK1/2 phosphorylation preincubated for 2 hrs followed by EGF stimu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ93Q2PubMed
TargetGTPase KRas(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514370(CHEMBL4588277)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:Inhibition of KRAS in human MIAPaca2 cells assessed as decrease in EGF-stimulated ERK1/2 phosphorylation preincubated for 2 hrs followed by EGF stimu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ93Q2PubMed
TargetGTPase KRas(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514395(CHEMBL4527861)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Inhibition of KRAS in human MIAPaca2 cells assessed as decrease in EGF-stimulated ERK1/2 phosphorylation preincubated for 2 hrs followed by EGF stimu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ93Q2PubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397798(CHEMBL2177836)copy SMILEScopy InChI
Affinity DataIC50: 44nMAssay Description:Inhibition of Akt1 in human AN3CA cells assessed as phosphorylation of Akt at S473 after 2 hrs by Western Blot analysisMore data for this Ligand-Target Pair
TargetGTPase KRas(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514378(CHEMBL4450657)copy SMILEScopy InChI
Affinity DataIC50: 44nMAssay Description:Inhibition of KRAS in human MIAPaca2 cells assessed as decrease in EGF-stimulated ERK1/2 phosphorylation preincubated for 2 hrs followed by EGF stimu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ93Q2PubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397798(CHEMBL2177836)copy SMILEScopy InChI
Affinity DataIC50: 45nMAssay Description:Inhibition of Akt 1 in human AN3CA cells assessed as phosphorylation of Akt at T308 after 2 hrs by Western Blot analysisMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397783(CHEMBL2177833)copy SMILEScopy InChI
Affinity DataIC50: 46nMAssay Description:Inhibition of Akt1 in human AN3CA cells assessed as phosphorylation of Akt at S473 after 2 hrs by Western Blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397794(CHEMBL2177827)copy SMILEScopy InChI
Affinity DataIC50: 46nMAssay Description:Inhibition of Akt1 in human A2780 cells assessed as phosphorylation of Akt at S473 after 2 hrs by Western Blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397782(CHEMBL2177834)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Inhibition of Akt2 (1 to 481) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetGTPase KRas(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514387(CHEMBL4465551)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Inhibition of KRAS in human MIAPaca2 cells assessed as decrease in EGF-stimulated ERK1/2 phosphorylation preincubated for 2 hrs followed by EGF stimu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ93Q2PubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397789(CHEMBL2177837)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Inhibition of Akt1 (1 to 480) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397794(CHEMBL2177827)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Inhibition of Akt1 in human AN3CA cells assessed as phosphorylation of Akt at S473 after 2 hrs by Western Blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397794(CHEMBL2177827)copy SMILEScopy InChI
Affinity DataIC50: 49nMAssay Description:Inhibition of Akt 1 in human AN3CA cells assessed as phosphorylation of Akt at T308 after 2 hrs by Western Blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397783(CHEMBL2177833)copy SMILEScopy InChI
Affinity DataIC50: 49nMAssay Description:Inhibition of Akt 1 in human AN3CA cells assessed as phosphorylation of Akt at T308 after 2 hrs by Western Blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
ArQule Inc.

Curated by ChEMBL
LigandPNGBDBM50397792(CHEMBL2177829)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of Akt1 (1 to 480) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3G5JPubMed
TargetGTPase KRas(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514378(CHEMBL4450657)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Inhibition of GDP bound recombinant human His-tagged KRAS G12C/C118A mutant (1 to 169 residues) assessed as reduction in SOS1-mediated GDP/GTP nucleo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ93Q2PubMed
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