Compile Data Set for Download or QSAR
Found 288 with Last Name = 'marcin' and Initial = 'lr'
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM22416((3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-f...)copy SMILEScopy InChI
Affinity DataKi:  0.0400nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173715((+)3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1...)copy SMILEScopy InChI
Affinity DataKi:  0.180nMAssay Description:In vitro binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173715((+)3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1...)copy SMILEScopy InChI
Affinity DataKi:  0.560nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173710(3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1H-i...)copy SMILEScopy InChI
Affinity DataKi:  0.580nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)copy SMILEScopy InChI
Affinity DataKi:  0.720nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMedDrugBank
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50209103(CHEMBL3885379)copy SMILEScopy InChI
Affinity DataKi:  1nMAssay Description:Displacement of [3H]-JNJ-40068782 from human mGlu2 receptor expressed in HEK293 cell membranes coexpressing rat glutamate transporter measured after ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR504DPubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM198665(US9221796, 2b)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]Ro 25-6981 from GluN2B receptor in Sprague-Dawley rat forebrain membranes incubated for 1 hr by topcount micro scintillation coun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7ZJTPubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM198694(US9221796, 23b)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]Ro 25-6981 from GluN2B receptor in Sprague-Dawley rat forebrain membranes incubated for 1 hr by topcount micro scintillation coun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7ZJTPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173712(3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1-et...)copy SMILEScopy InChI
Affinity DataKi:  1.80nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50162700(3-(3-(dimethylamino)propyl)-1H-indole-5-carbonitri...)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173717(((1S,2S)-2-(5-fluoro-1H-indol-3-yl)cyclopropyl)-N,...)copy SMILEScopy InChI
Affinity DataKi:  2.10nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173717(((1S,2S)-2-(5-fluoro-1H-indol-3-yl)cyclopropyl)-N,...)copy SMILEScopy InChI
Affinity DataKi:  2.10nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM198728(US9221796, 46, P-4)copy SMILEScopy InChI
Affinity DataKi:  4nMAssay Description:Displacement of [3H]Ro 25-6981 from GluN2B receptor in Sprague-Dawley rat forebrain membranes incubated for 1 hr by topcount micro scintillation coun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7ZJTPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50162708(3-(5-fluoro-1H-indol-3-yl)-N,N-dimethylpropan-1-am...)copy SMILEScopy InChI
Affinity DataKi:  4nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM198726(US9221796, 46, P-2)copy SMILEScopy InChI
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]Ro 25-6981 from GluN2B receptor in Sprague-Dawley rat forebrain membranes incubated for 1 hr by topcount micro scintillation coun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7ZJTPubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50330324(CHEMBL4170867)copy SMILEScopy InChI
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]Ro 25-6981 from GluN2B receptor in Sprague-Dawley rat forebrain membranes incubated for 1 hr by topcount micro scintillation coun...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7ZJTPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173706(3-((1R,2S)-2-Dimethylaminomethyl-cyclopropyl)-1H-i...)copy SMILEScopy InChI
Affinity DataKi:  5.70nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM198728(US9221796, 46, P-4)copy SMILEScopy InChI
Affinity DataKi:  6.30nMAssay Description:Binding affinity to GluN2B receptor in human cortexMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7ZJTPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173713(3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1-me...)copy SMILEScopy InChI
Affinity DataKi:  6.5nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173709(3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1H-i...)copy SMILEScopy InChI
Affinity DataKi:  7.40nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50330409(CHEMBL4168402)copy SMILEScopy InChI
Affinity DataKi:  7.70nMAssay Description:Displacement of [3H]Ro 25-6981 from GluN2B receptor in Sprague-Dawley rat forebrain membranes incubated for 1 hr by topcount micro scintillation coun...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7ZJTPubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50330410(CHEMBL4161899)copy SMILEScopy InChI
Affinity DataKi:  8.40nMAssay Description:Displacement of [3H]Ro 25-6981 from GluN2B receptor in Sprague-Dawley rat forebrain membranes incubated for 1 hr by topcount micro scintillation coun...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7ZJTPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173705((-)3-((1R,2R)-2-Dimethylaminomethyl-cyclopropyl)-1...)copy SMILEScopy InChI
Affinity DataKi:  8.90nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173714(CHEMBL364050 | [(1S,2S)-2-(7-Fluoro-1H-indol-3-yl)...)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM198735(US9221796, 48, P-3)copy SMILEScopy InChI
Affinity DataKi:  11nMAssay Description:Displacement of [3H]Ro 25-6981 from GluN2B receptor in Sprague-Dawley rat forebrain membranes incubated for 1 hr by topcount micro scintillation coun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7ZJTPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173711((+)3-((1S,2R)-2-Dimethylaminomethyl-cyclopropyl)-1...)copy SMILEScopy InChI
Affinity DataKi:  17nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173703((-)[(1R,2S)-2-(5-Fluoro-1H-indol-3-yl)-cyclopropyl...)copy SMILEScopy InChI
Affinity DataKi:  24nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173703((-)[(1R,2S)-2-(5-Fluoro-1H-indol-3-yl)-cyclopropyl...)copy SMILEScopy InChI
Affinity DataKi:  24nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173701(CHEMBL194960 | [(1S,2S)-2-(6-Fluoro-1H-indol-3-yl)...)copy SMILEScopy InChI
Affinity DataKi:  38nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173704((-)[(1R,2R)-2-(5-Fluoro-1H-indol-3-yl)-cyclopropyl...)copy SMILEScopy InChI
Affinity DataKi:  41nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173716(CHEMBL194909 | [(1S,2S)-2-(4-Fluoro-1H-indol-3-yl)...)copy SMILEScopy InChI
Affinity DataKi:  59nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM22416((3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-f...)copy SMILEScopy InChI
Affinity DataKi:  90nMAssay Description:Binding inhibition towards human norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMedDrugBank
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173707((+)[(1S,2R)-2-(5-Fluoro-1H-indol-3-yl)-cyclopropyl...)copy SMILEScopy InChI
Affinity DataKi:  100nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173702(3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1H-i...)copy SMILEScopy InChI
Affinity DataKi:  230nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173702(3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1H-i...)copy SMILEScopy InChI
Affinity DataKi:  230nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM22416((3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-f...)copy SMILEScopy InChI
Affinity DataKi:  400nMAssay Description:Binding inhibition towards human dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)copy SMILEScopy InChI
Affinity DataKi:  440nMAssay Description:Binding inhibition towards human norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)copy SMILEScopy InChI
Affinity DataKi:  1.90E+3nMAssay Description:Binding inhibition towards human dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173715((+)3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1...)copy SMILEScopy InChI
Affinity DataKi:  2.10E+3nMAssay Description:Binding inhibition towards human dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173715((+)3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1...)copy SMILEScopy InChI
Affinity DataKi:  4.60E+3nMAssay Description:In vitro binding affinity towards human norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96DNPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))TBA
LigandPNGBDBM50458163(CHEMBL4209316)copy SMILEScopy InChI
Affinity DataKi:  8.30E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24171P7PubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50295294((+/-)-trans-3-(2-((dimethylamino)methyl)cyclopenty...)copy SMILEScopy InChI
Affinity DataIC50: 0.130nMAssay Description:Displacement of [I125]RTI-55 from human SERT transfected in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125SSBPubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50485806(CHEMBL2164125)copy SMILEScopy InChI
Affinity DataIC50: 0.190nMAssay Description:Inhibition of human gamma-secretase expressed in IMR32 cell membranes using MBPC-125 Swedish as substrate assessed as inhibition of amyloid beta40 pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NBTPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173715((+)3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 0.360nMAssay Description:Displacement of [I125]RTI-55 from human SERT transfected in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125SSBPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173715((+)3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 0.480nMAssay Description:Inhibition of human SERTMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP82Z6PubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50209168((R)-3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indole...)copy SMILEScopy InChI
Affinity DataIC50: 0.720nMAssay Description:Displacement of [I125]RTI-55 from human SERT transfected in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125SSBPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50309602((+)-3-(2-(2-methyl-1,2,3,4-tetrahydroisoquinolin-1...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Displacement of [I125]RTI-55 from human SERT transfected in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125SSBPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50309602((+)-3-(2-(2-methyl-1,2,3,4-tetrahydroisoquinolin-1...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Displacement of [I125]RTI-55 from human SERT transfected in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125SSBPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173705((-)3-((1R,2R)-2-Dimethylaminomethyl-cyclopropyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human SERTMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP82Z6PubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50162700(3-(3-(dimethylamino)propyl)-1H-indole-5-carbonitri...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human SERTMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP82Z6PubMed
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