Compile Data Set for Download or QSAR
Found 273 with Last Name = 'terrell' and Initial = 'lr'
LigandPNGBDBM50521182(CHEMBL4456312 | US11260049, Ex. 123)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity at human TRPV4 expressed in BHK/AC9 cells assessed as inhibition of GSK634775-induced calcium immobilization pre-incubated for 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5KD5PubMed
LigandPNGBDBM50521192(CHEMBL4547537 | US11260049, Ex. 121)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at human TRPV4 expressed in BHK/AC9 cells assessed as inhibition of GSK634775-induced calcium immobilization pre-incubated for 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5KD5PubMed
LigandPNGBDBM50521183(CHEMBL4461475 | US11260049, Ex. 125)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at human TRPV4 expressed in BHK/AC9 cells assessed as inhibition of GSK634775-induced calcium immobilization pre-incubated for 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5KD5PubMed
LigandPNGBDBM50521183(CHEMBL4461475 | US11260049, Ex. 125)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Antagonist activity at rat TRPV4 expressed in BHK/AC9 cells assessed as inhibition of GSK634775-induced calcium immobilization pre-incubated for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5KD5PubMed
LigandPNGBDBM50554960(CHEMBL4749555)copy SMILES
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at human TRPV4 expressed in BHK or HEK MSR2 cells assessed as inhibition of TRPV4 agonist GSK634775 (EC80)-induced response incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4PFKPubMed
LigandPNGBDBM50502640(CHEMBL4470585)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at human TRPV4More data for this Ligand-Target Pair
LigandPNGBDBM50521185(CHEMBL4439448 | US11260049, Ex. 83)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human TRPV4 expressed in BHK/AC9 cells assessed as inhibition of GSK634775-induced calcium immobilization pre-incubated for 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5KD5PubMed
LigandPNGBDBM50521195(CHEMBL4586959 | US11260049, Ex. 84)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human TRPV4 expressed in BHK/AC9 cells assessed as inhibition of GSK634775-induced calcium immobilization pre-incubated for 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5KD5PubMed
LigandPNGBDBM50505550(CHEMBL4439190 | US11260049, Ex. 2)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at human TRPV4 expressed in BHK/AC9 cells assessed as inhibition of GSK634775-induced calcium immobilization pre-incubated for 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5KD5PubMed
LigandPNGBDBM50521186(CHEMBL4547101 | US11260049, Ex. 45)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at human TRPV4 expressed in BHK/AC9 cells assessed as inhibition of GSK634775-induced calcium immobilization pre-incubated for 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5KD5PubMed
LigandPNGBDBM50505550(CHEMBL4439190 | US11260049, Ex. 2)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at human TRPV4More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N30173PubMed
LigandPNGBDBM50505551(CHEMBL4517101)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMAssay Description:Antagonist activity at BacMam virus expressing human TRPV4 transduced in BHK/AC9 or HEK MSR2 cells assessed as inhibition of GSK634775-induced Ca2+ f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N30173PubMed
LigandPNGBDBM50505543(CHEMBL4454801)copy SMILEScopy InChI
Affinity DataIC50: 3.80nMAssay Description:Antagonist activity at BacMam virus expressing human TRPV4 transduced in BHK/AC9 or HEK MSR2 cells assessed as inhibition of GSK634775-induced Ca2+ f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N30173PubMed
LigandPNGBDBM50505550(CHEMBL4439190 | US11260049, Ex. 2)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Antagonist activity at rat TRPV4 expressed in BHK/AC9 cells assessed as inhibition of GSK634775-induced calcium immobilization pre-incubated for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5KD5PubMed
TargetShort transient receptor potential channel 6(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50439218(CHEMBL2418809)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2319X9HPubMed
LigandPNGBDBM539936(4-(((3R,4S)-4-((4-bromophenyl)sulfonyl)-3-hydroxy-...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539981(3-chloro-4-(((3R,4S)-4-((5-chloropyridin-2-yl)sulf...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539910(4-(((3R,4S)-4- ((4-chloro- phenyl)sulfonyl)- 3-hyd...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM50521180(CHEMBL4437115 | US11260049, Ex. 1)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM50505550(CHEMBL4439190 | US11260049, Ex. 2)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539865(4-(((3S,4S)-1- ((2-chloro-4- cyanophenyl)sulfonyl)...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539874(4-(((3S,4R)-1- ((2-chloro-4- fluorophenyl)sulfonyl...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539875(4-(((3S,4R)-1- ((2-chloro-4- methylphenyl)sulfonyl...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539876(2-chloro-4-(difluoro- methyl)benzene-1- sulfonyl c...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539872(4-(((3S,4R)-1- ((2-chloro-4- cyanophenyl)sulfonyl)...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539878(4-chloro-2- methoxybenzene- 1-sulfonyl chloride | ...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539879(5-chloro-2- (((3R,4S)-4-((4- chlorophenyl)sulfonyl...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539916(3-chloro-4- (((3R,4S)-3- hydroxy-3- (hydroxymethyl...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539917(3- (difluoromethyl)- 4-(((3R,4S)-3- hydroxy-3- (hy...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539921(4-(((3S,4R)-1- ((2-bromo-4- chlorophenyl)sulfonyl)...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539969(3-chloro-4- (((3R,4S)-4-((4- chloro-3- fluoropheny...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM50521192(CHEMBL4547537 | US11260049, Ex. 121)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM50521182(CHEMBL4456312 | US11260049, Ex. 123)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM50521183(CHEMBL4461475 | US11260049, Ex. 125)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539932(4-(((3S,4R)-1- ((4-cyano-2-methyl- phenyl)sulfonyl...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539937(4-(((3S,4S)-1- ((2,4- dichlorophenyl) sulfonyl)-4-...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM50505546(CHEMBL4533534 | US11260049, Ex. 82)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM50521195(CHEMBL4586959 | US11260049, Ex. 84)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539949(4-(((3S,4R)-1- ((2,4- dichlorophenyl) sulfonyl)-4-...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539881(4-(((3R,4S)-4- ((4-chloro- phenyl)sulfonyl)- 3-hyd...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539887(4-(((3S,4R)-1- ((4-chloro-2- (trifluoromethyl) phe...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539891(4-(((3S,4R)-1- ((4-fluoro-2- (trifluoromethyl) phe...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539892(4-(((3S,4R)-1- ((4-bromo-2- (trifluoromethyl) phen...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539896(4-(((3S,4R)-1- ((4-bromo-2- chlorophenyl)sulfonyl)...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539897(4-(((3R,4S)-4- ((4-chloro- phenyl)sulfonyl)- 3-hyd...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539900(3-bromo-4- (((3R,4S)-4-((4- chlorophenyl)sulfonyl)...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM50521186(CHEMBL4547101 | US11260049, Ex. 45)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539975(4-(((3R,4S)-4-((5- bromopyridin-2- yl)sulfonyl)-3-...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539979(2-(((3R,4S)-4-((4- chlorophenyl) sulfonyl)-3- hydr...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
LigandPNGBDBM539982(3-chloro-4-(((3R,4S)-4-((5-chloropyridin-2-yl)sulf...)copy SMILES
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85C9ZUS Patent
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