Compile Data Set for Download or QSAR
Found 406 with Last Name = 'lafrance' and Initial = 'lv'
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM25004(3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(3-aminoprop...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM24994(4-[1-ethyl-7-(piperidin-4-ylmethoxy)-1H-imidazo[4,...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM25004(3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(3-aminoprop...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM25013(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM25009(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(2-aminoetho...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM25010(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-[(3S)-3-amin...)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM25014(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3R...)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM24994(4-[1-ethyl-7-(piperidin-4-ylmethoxy)-1H-imidazo[4,...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM24991(4-(7-{[(3R)-3-aminopyrrolidin-1-yl]carbonyl}-1-eth...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM25016((2S)-3-[(3-{[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-et...)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM25010(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-[(3S)-3-amin...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM25015(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(3-{...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM24991(4-(7-{[(3R)-3-aminopyrrolidin-1-yl]carbonyl}-1-eth...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM24990(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-[2-(met...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM25016((2S)-3-[(3-{[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-et...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM25003(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(3-aminoprop...)copy SMILEScopy InChI
Affinity DataIC50: 6nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM25005(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(3-aminoprop...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRho-associated protein kinase 1(Rattus norvegicus (Rat))
GlaxoSmithKline

LigandPNGBDBM24995(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-(piperi...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM25015(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(3-{...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM25011(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(pyr...)copy SMILEScopy InChI
Affinity DataIC50: 8nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM25012(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(pip...)copy SMILEScopy InChI
Affinity DataIC50: 8nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM24989(4-[1-ethyl-7-(piperidin-4-yloxy)-1H-imidazo[4,5-c]...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM25012(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(pip...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM24996(4-{1-ethyl-7-[(piperidin-4-ylamino)methyl]-1H-imid...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM25008(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(pip...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM25007(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(4-aminobuto...)copy SMILEScopy InChI
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM25013(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM25007(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(4-aminobuto...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
LigandPNGBDBM259367(US9505745, 44 | US9505745, 45 | US9790212, Example...)copy SMILES
Affinity DataIC50: 10nMAssay Description:Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23B5Z3TUS Patent
LigandPNGBDBM259356(US9505745, 33 | US9790212, Example 33)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23B5Z3TUS Patent
LigandPNGBDBM347682(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)copy SMILES
Affinity DataIC50: 10nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2US Patent
LigandPNGBDBM259335(US9505745, 12 | US9790212, Example 12)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2US Patent
LigandPNGBDBM259342(US9505745, 19 | US9790212, Example 19)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2US Patent
LigandPNGBDBM259355(US9505745, 32 | US9790212, Example 32)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2US Patent
LigandPNGBDBM259356(US9505745, 33 | US9790212, Example 33)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2US Patent
LigandPNGBDBM259359(US9505745, 36 | US9790212, Example 36)copy SMILES
Affinity DataIC50: 10nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2US Patent
LigandPNGBDBM259367(US9505745, 44 | US9505745, 45 | US9790212, Example...)copy SMILES
Affinity DataIC50: 10nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2US Patent
LigandPNGBDBM347682(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)copy SMILES
Affinity DataIC50: 10nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2US Patent
LigandPNGBDBM259339(US9505745, 16 | US9790212, Example 16)copy SMILES
Affinity DataIC50: 10nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2US Patent
LigandPNGBDBM259341(US9505745, 18 | US9790212, Example 18)copy SMILES
Affinity DataIC50: 10nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PZ5BZ2US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

US Patent
LigandPNGBDBM439129((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...)copy SMILES
Affinity DataIC50: 10nMAssay Description:1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23X89N4US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

US Patent
LigandPNGBDBM439130((R)-2-(1-(1-(Cyclobutylmethyl)piperidin-4-yl)ethyl...)copy SMILES
Affinity DataIC50: 10nMAssay Description:1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23X89N4US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

US Patent
LigandPNGBDBM439132((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...)copy SMILES
Affinity DataIC50: 10nMAssay Description:1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23X89N4US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

US Patent
LigandPNGBDBM439133((R)-2-(1-(1-(Cyclopentylmethyl)piperidin-4-yl)ethy...)copy SMILES
Affinity DataIC50: 10nMAssay Description:1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23X89N4US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

US Patent
LigandPNGBDBM439163((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...)copy SMILES
Affinity DataIC50: 10nMAssay Description:1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23X89N4US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

US Patent
LigandPNGBDBM439164((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...)copy SMILES
Affinity DataIC50: 10nMAssay Description:1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23X89N4US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

US Patent
LigandPNGBDBM439165((R)-2-(1-(1-(Cyclopropylmethyl)piperidin-4-yl)ethy...)copy SMILES
Affinity DataIC50: 10nMAssay Description:1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23X89N4US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

US Patent
LigandPNGBDBM439169((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...)copy SMILES
Affinity DataIC50: 10nMAssay Description:1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23X89N4US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

US Patent
LigandPNGBDBM439190((R)-2-(1-(1-(Bicyclo[2.2.2]octan-1-ylmethyl)piperi...)copy SMILES
Affinity DataIC50: 10nMAssay Description:1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23X89N4US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

US Patent
LigandPNGBDBM439192((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...)copy SMILES
Affinity DataIC50: 10nMAssay Description:1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23X89N4US Patent
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