Compile Data Set for Download or QSAR
Found 89 with Last Name = 'calabrese' and Initial = 'm'
Target5'-AMP-activated protein kinase subunit beta-1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM237920(US9394285, 1)copy SMILEScopy InChI
Affinity DataIC50: 400nMAssay Description:Activation of recombinant AMPKbeta1 in cryopreserved human hepatocytes assessed as reduction in 14C-2-acetic acid incorporation after 1 hr by scintil...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase subunit beta-1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM238079(US9394285, 173)copy SMILEScopy InChI
Affinity DataIC50: 420nMAssay Description:Activation of recombinant AMPKbeta1 in cryopreserved human hepatocytes assessed as reduction in 14C-2-acetic acid incorporation after 1 hr by scintil...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase subunit beta-1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50463100(CHEMBL4249790)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+4nMAssay Description:Activation of recombinant AMPKbeta1 in cryopreserved human hepatocytes assessed as reduction in 14C-2-acetic acid incorporation after 1 hr by scintil...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM237920(US9394285, 1)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of PDE3A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5BRCPubMed
Target5'-AMP-activated protein kinase subunit beta-1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50463101(CHEMBL4250253)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:Activation of recombinant AMPKbeta1 in cryopreserved human hepatocytes assessed as reduction in 14C-2-acetic acid incorporation after 1 hr by scintil...More data for this Ligand-Target Pair
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)copy SMILEScopy InChI
Affinity DataEC50:  1.52E+3nMAssay Description:Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphoryl...More data for this Ligand-Target Pair
LigandPNGBDBM237920(US9394285, 1)copy SMILEScopy InChI
Affinity DataEC50:  7nMAssay Description:Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphoryl...More data for this Ligand-Target Pair
LigandPNGBDBM237921(US9394285, 2)copy SMILEScopy InChI
Affinity DataKd:  150nMAssay Description:Binding affinity to recombinant human AMPK alpha1/beta1/gamma1 by SPR binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5BRCPubMed
Target5'-AMP-activated protein kinase subunit gamma-1(Rattus norvegicus)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM237920(US9394285, 1)copy SMILEScopy InChI
Affinity DataEC50:  7nMAssay Description:Activation of recombinant rat AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphorylat...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase subunit gamma-1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM237920(US9394285, 1)copy SMILEScopy InChI
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of recombinant human AMPK alpha2/beta2/gamma1 using Cy5-labelled SAMS as substrate in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
LigandPNGBDBM237920(US9394285, 1)copy SMILEScopy InChI
Affinity DataEC50:  3.30nMAssay Description:Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
LigandPNGBDBM237920(US9394285, 1)copy SMILEScopy InChI
Affinity DataEC50:  28nMAssay Description:Activation of recombinant human BAP-tagged AMPK alpha1/beta1/gamma1 assessed as protection from Thr172 residue dephosphorylation preincubated for 15 ...More data for this Ligand-Target Pair
LigandPNGBDBM237920(US9394285, 1)copy SMILEScopy InChI
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of recombinant human AMPK alpha1/beta2/gamma1 using Cy5-labelled SAMS as substrate in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
LigandPNGBDBM237952(US9394285, 33)copy SMILEScopy InChI
Affinity DataEC50:  80nMAssay Description:Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphoryl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5BRCPubMed
LigandPNGBDBM237921(US9394285, 2)copy SMILEScopy InChI
Affinity DataEC50:  53nMAssay Description:Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphoryl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5BRCPubMed
LigandPNGBDBM237952(US9394285, 33)copy SMILEScopy InChI
Affinity DataKd:  90nMAssay Description:Binding affinity to recombinant human AMPK alpha1/beta1/gamma1 by SPR binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5BRCPubMed
LigandPNGBDBM237984(US9394285, 67)copy SMILEScopy InChI
Affinity DataKd:  23nMAssay Description:Binding affinity to recombinant human AMPK alpha1/beta1/gamma1 by SPR binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5BRCPubMed
Target5'-AMP-activated protein kinase subunit beta-2(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM237920(US9394285, 1)copy SMILEScopy InChI
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of recombinant human AMPK alpha2/beta2/gamma3 by using Cy5-labelled SAMS as substrate in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5BRCPubMed
LigandPNGBDBM60978(6-Chloro-5-(4-methoxyphenyl)-1H-indazole-3-carboxy...)copy SMILEScopy InChI
Affinity DataKd:  1.78E+3nMAssay Description:Binding affinity to recombinant human AMPK alpha1/beta1/gamma1 by SPR binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5BRCPubMed
LigandPNGBDBM237984(US9394285, 67)copy SMILEScopy InChI
Affinity DataEC50:  1.30nMAssay Description:Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphoryl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5BRCPubMed
LigandPNGBDBM237920(US9394285, 1)copy SMILEScopy InChI
Affinity DataKd:  9nMAssay Description:Binding affinity to recombinant human AMPK alpha1/beta1/gamma1 by SPR binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM237920(US9394285, 1)copy SMILEScopy InChI
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human recombinant 5-HT2b receptor expressed in CHO cells measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5BRCPubMed
LigandPNGBDBM237923(US9394285, 4)copy SMILEScopy InChI
Affinity DataKd:  48nMAssay Description:Binding affinity to human BAP-tagged AMPK alpha1/beta1/gamma1 by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028TZTPubMed
LigandPNGBDBM237925(US9394285, 6)copy SMILEScopy InChI
Affinity DataKd:  20nMAssay Description:Binding affinity to human BAP-tagged AMPK alpha1/beta1/gamma1 by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028TZTPubMed
LigandPNGBDBM238084(US9394285, 178 | US9394285, 179)copy SMILES
Affinity DataKd:  14nMAssay Description:Binding affinity to human BAP-tagged AMPK alpha1/beta1/gamma1 by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028TZTPubMed
LigandPNGBDBM50244636(CHEMBL4087189)copy SMILEScopy InChI
Affinity DataKd:  1.70E+3nMAssay Description:Binding affinity to human BAP-tagged AMPK alpha1/beta1/gamma1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028TZTPubMed
LigandPNGBDBM50244665(CHEMBL4097332)copy SMILEScopy InChI
Affinity DataKd:  410nMAssay Description:Binding affinity to human BAP-tagged AMPK alpha1/beta1/gamma1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028TZTPubMed
LigandPNGBDBM237920(US9394285, 1)copy SMILEScopy InChI
Affinity DataKd:  9nMAssay Description:Binding affinity to human BAP-tagged AMPK alpha1/beta1/gamma1 by SPR assayMore data for this Ligand-Target Pair
LigandPNGBDBM50244667(CHEMBL4105032)copy SMILEScopy InChI
Affinity DataKd:  14nMAssay Description:Binding affinity to human BAP-tagged AMPK alpha1/beta1/gamma1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028TZTPubMed
LigandPNGBDBM50244665(CHEMBL4097332)copy SMILEScopy InChI
Affinity DataEC50:  270nMAssay Description:Allosteric activation of human AMPK alpha1/beta1/gamma1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028TZTPubMed
LigandPNGBDBM50244668(CHEMBL4059813)copy SMILEScopy InChI
Affinity DataEC50:  62nMAssay Description:Allosteric activation of human AMPK alpha1/beta1/gamma1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028TZTPubMed
LigandPNGBDBM238084(US9394285, 178 | US9394285, 179)copy SMILES
Affinity DataEC50:  24nMAssay Description:Allosteric activation of human AMPK alpha1/beta1/gamma1 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028TZTPubMed
LigandPNGBDBM237958(US9394285, 39)copy SMILEScopy InChI
Affinity DataEC50:  43nMAssay Description:Allosteric activation of human AMPK alpha1/beta1/gamma1 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028TZTPubMed
LigandPNGBDBM238051(US9394285, 139)copy SMILEScopy InChI
Affinity DataEC50:  47nMAssay Description:Allosteric activation of human AMPK alpha1/beta1/gamma1 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028TZTPubMed
LigandPNGBDBM237925(US9394285, 6)copy SMILEScopy InChI
Affinity DataEC50:  35nMAssay Description:Allosteric activation of human AMPK alpha1/beta1/gamma1 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028TZTPubMed
LigandPNGBDBM237931(US9394285, 12)copy SMILEScopy InChI
Affinity DataEC50:  100nMAssay Description:Allosteric activation of human AMPK alpha1/beta1/gamma1 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028TZTPubMed
LigandPNGBDBM50244667(CHEMBL4105032)copy SMILEScopy InChI
Affinity DataEC50:  22nMAssay Description:Allosteric activation of human AMPK alpha1/beta1/gamma1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028TZTPubMed
LigandPNGBDBM237920(US9394285, 1)copy SMILEScopy InChI
Affinity DataEC50:  5.60nMAssay Description:Allosteric activation of human AMPK alpha1/beta1/gamma1 by TR-FRET assayMore data for this Ligand-Target Pair
LigandPNGBDBM50244669(CHEMBL4079303)copy SMILEScopy InChI
Affinity DataEC50:  1.60E+3nMAssay Description:Allosteric activation of human AMPK alpha1/beta1/gamma1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028TZTPubMed
LigandPNGBDBM237931(US9394285, 12)copy SMILEScopy InChI
Affinity DataKd:  48nMAssay Description:Binding affinity to human BAP-tagged AMPK alpha1/beta1/gamma1 by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028TZTPubMed
LigandPNGBDBM237958(US9394285, 39)copy SMILEScopy InChI
Affinity DataKd:  22nMAssay Description:Binding affinity to human BAP-tagged AMPK alpha1/beta1/gamma1 by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028TZTPubMed
LigandPNGBDBM50244669(CHEMBL4079303)copy SMILEScopy InChI
Affinity DataKd:  580nMAssay Description:Binding affinity to human BAP-tagged AMPK alpha1/beta1/gamma1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028TZTPubMed
LigandPNGBDBM238086(US9394285, 181)copy SMILEScopy InChI
Affinity DataEC50:  57nMAssay Description:Allosteric activation of human AMPK alpha1/beta1/gamma1 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028TZTPubMed
LigandPNGBDBM237923(US9394285, 4)copy SMILEScopy InChI
Affinity DataEC50:  52nMAssay Description:Allosteric activation of human AMPK alpha1/beta1/gamma1 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028TZTPubMed
LigandPNGBDBM238079(US9394285, 173)copy SMILEScopy InChI
Affinity DataEC50:  12nMAssay Description:Allosteric activation of human AMPK alpha1/beta1/gamma1 by TR-FRET assayMore data for this Ligand-Target Pair
LigandPNGBDBM50463099(CHEMBL4246000)copy SMILEScopy InChI
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of full-length recombinant N-terminal His-tagged human AMPKalpha1beta2gamma1 expressed in Escherichia coli BL21 cells using Cy-5 SAMS pept...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase subunit beta-2(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM238079(US9394285, 173)copy SMILEScopy InChI
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of full-length recombinant N-terminal His-tagged human AMPKalpha2beta2gamma3 expressed in Escherichia coli BL21 cells using Cy-5 SAMS pept...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242WTPubMed
LigandPNGBDBM50463100(CHEMBL4249790)copy SMILEScopy InChI
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of full-length recombinant N-terminal His-tagged human AMPKalpha1beta2gamma1 expressed in Escherichia coli BL21 cells using Cy-5 SAMS pept...More data for this Ligand-Target Pair
LigandPNGBDBM50463100(CHEMBL4249790)copy SMILEScopy InChI
Affinity DataEC50:  38nMAssay Description:Activation of full-length recombinant N-terminal His-tagged human AMPKalpha1beta1gamma1 expressed in Escherichia coli BL21 cells using Cy-5 SAMS pept...More data for this Ligand-Target Pair
LigandPNGBDBM50244667(CHEMBL4105032)copy SMILEScopy InChI
Affinity DataEC50:  6nMAssay Description:Activation of full-length recombinant N-terminal His-tagged human AMPKalpha2beta1gamma1 expressed in Escherichia coli BL21 cells using Cy-5 SAMS pept...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242WTPubMed
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