TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Affinity DataIC50: 3.10nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 3.30nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of mouse recombinant Aurora A kinase expressed in insect Sf9 cells by radioactive flashplate assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Affinity DataIC50: 4.20nMAssay Description:Inhibition of wild-type B-RafMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 4.5nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Affinity DataIC50: 4.70nMAssay Description:Inhibition of wild-type B-RafMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 6.20nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Affinity DataIC50: 9.5nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
TargetEphrin type-A receptor 2(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
TargetEphrin type-A receptor 2(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of Aurora A Thr288 autophosphorylation in human HeLa cells after 1 hrMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Inhibition of CDK5/p35NCK (unknown origin) using histone H1 as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) using RPPTLSPIPHIPR peptide as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Takeda Pharmaceuticals International Co. 40 Landsdowne Street, Cambridge, MA 02139, United States.
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair