Compile Data Set for Download or QSAR
Found 54 with Last Name = 'hérin' and Initial = 'm'
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50202406((+)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...)copy SMILEScopy InChI
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR3 in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z442NPubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50202406((+)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...)copy SMILEScopy InChI
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR3 in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z442NPubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50202406((+)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...)copy SMILEScopy InChI
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR2 in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z442NPubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50202406((+)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...)copy SMILEScopy InChI
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR2 in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z442NPubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50074750((1R,4S,5S,6S)-4-amino-2-thia-bicyclo[3.1.0]hexane-...)copy SMILEScopy InChI
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR3 in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z442NPubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50074749((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...)copy SMILEScopy InChI
Affinity DataKi:  5.80nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR3 in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z442NPubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50074749((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...)copy SMILEScopy InChI
Affinity DataKi:  14.1nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR2 in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z442NPubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50074750((1R,4S,5S,6S)-4-amino-2-thia-bicyclo[3.1.0]hexane-...)copy SMILEScopy InChI
Affinity DataKi:  40.6nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR2 in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z442NPubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50056272((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...)copy SMILEScopy InChI
Affinity DataKi:  74.9nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR2 in RGT cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50202407((-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexa...)copy SMILEScopy InChI
Affinity DataKi:  92nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR3 in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z442NPubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50056272((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...)copy SMILEScopy InChI
Affinity DataKi:  93.3nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR3 in RGT cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50202407((-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexa...)copy SMILEScopy InChI
Affinity DataKi:  149nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR2 in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z442NPubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50062520((1S,2S)-2-((R)-1-Amino-1-carboxy-3-m-tolyl-propyl)...)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7423PubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50408697(CHEMBL2112634)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7423PubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50062534((S)-2-[(R)-1-Amino-1-carboxy-3-(3-methoxy-phenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7423PubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50062543((1S,2S)-2-((S)-1-Amino-1-carboxy-3,3-diphenyl-prop...)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7423PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50062518((S)-2-[(R)-1-Amino-1-carboxy-3-(3-chloro-phenyl)-p...)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7423PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50062526((S)-2-[(R)-1-Amino-1-carboxy-3-(4-fluoro-phenyl)-p...)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7423PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50062520((1S,2S)-2-((R)-1-Amino-1-carboxy-3-m-tolyl-propyl)...)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7423PubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50062518((S)-2-[(R)-1-Amino-1-carboxy-3-(3-chloro-phenyl)-p...)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7423PubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50408696(CHEMBL2111822)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7423PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50408696(CHEMBL2111822)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7423PubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50062539((S)-2-[(R)-1-Amino-3-(3-amino-phenyl)-1-carboxy-pr...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7423PubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50062526((S)-2-[(R)-1-Amino-1-carboxy-3-(4-fluoro-phenyl)-p...)copy SMILEScopy InChI
Affinity DataIC50: 210nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7423PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50062538((S)-2-[(R)-1-Amino-1-carboxy-3-(3-trifluoromethyl-...)copy SMILEScopy InChI
Affinity DataIC50: 220nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7423PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50062543((1S,2S)-2-((S)-1-Amino-1-carboxy-3,3-diphenyl-prop...)copy SMILEScopy InChI
Affinity DataIC50: 220nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7423PubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50062529((S)-2-[(R)-1-Amino-1-carboxy-3-(3-hydroxy-phenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 260nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7423PubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50062538((S)-2-[(R)-1-Amino-1-carboxy-3-(3-trifluoromethyl-...)copy SMILEScopy InChI
Affinity DataIC50: 420nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7423PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50062534((S)-2-[(R)-1-Amino-1-carboxy-3-(3-methoxy-phenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 430nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7423PubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50408693(CHEMBL2112582)copy SMILEScopy InChI
Affinity DataIC50: 650nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7423PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50408693(CHEMBL2112582)copy SMILEScopy InChI
Affinity DataIC50: 850nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7423PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50062529((S)-2-[(R)-1-Amino-1-carboxy-3-(3-hydroxy-phenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7423PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50408697(CHEMBL2112634)copy SMILEScopy InChI
Affinity DataIC50: 1.80E+3nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7423PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50062539((S)-2-[(R)-1-Amino-3-(3-amino-phenyl)-1-carboxy-pr...)copy SMILEScopy InChI
Affinity DataIC50: 3.10E+3nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7423PubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50202406((+)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...)copy SMILEScopy InChI
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at human mGluR3 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z442NPubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50202407((-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexa...)copy SMILEScopy InChI
Affinity DataEC50:  48nMAssay Description:Agonist activity at human mGluR3 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z442NPubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50202407((-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexa...)copy SMILEScopy InChI
Affinity DataEC50:  4.78E+4nMAssay Description:Agonist activity at human mGluR8 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z442NPubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50074749((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...)copy SMILEScopy InChI
Affinity DataEC50:  4.60nMAssay Description:Agonist activity at human mGluR3 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z442NPubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50074749((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...)copy SMILEScopy InChI
Affinity DataEC50:  2.70nMAssay Description:Agonist activity at human mGluR2 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z442NPubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50056272((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...)copy SMILEScopy InChI
Affinity DataEC50:  11.1nMAssay Description:Agonist activity at human mGluR2 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50056272((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...)copy SMILEScopy InChI
Affinity DataEC50:  38nMAssay Description:Agonist activity at human mGluR3 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50202407((-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexa...)copy SMILEScopy InChI
Affinity DataEC50:  23.4nMAssay Description:Agonist activity at human mGluR2 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z442NPubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50202406((+)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...)copy SMILEScopy InChI
Affinity DataEC50:  0.0890nMAssay Description:Agonist activity at human mGluR2 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z442NPubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50074750((1R,4S,5S,6S)-4-amino-2-thia-bicyclo[3.1.0]hexane-...)copy SMILEScopy InChI
Affinity DataEC50:  7.34E+3nMAssay Description:Agonist activity at human mGluR8 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z442NPubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50074750((1R,4S,5S,6S)-4-amino-2-thia-bicyclo[3.1.0]hexane-...)copy SMILEScopy InChI
Affinity DataEC50:  3.90nMAssay Description:Agonist activity at human mGluR2 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z442NPubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50202406((+)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human mGluR8 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z442NPubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50202406((+)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...)copy SMILEScopy InChI
Affinity DataEC50:  3.07E+3nMAssay Description:Agonist activity at human mGluR8 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z442NPubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50202406((+)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...)copy SMILEScopy InChI
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at human mGluR3 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z442NPubMed
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