TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
AstraZeneca
AstraZeneca
Affinity DataKi: 4.30nM ΔG°: -47.3kJ/mole EC50: 14nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
AstraZeneca
AstraZeneca
Affinity DataKi: 5.10nM ΔG°: -46.9kJ/mole EC50: 8.64nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
AstraZeneca
AstraZeneca
Affinity DataKi: 10nM ΔG°: -45.2kJ/mole EC50: 15nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
AstraZeneca
AstraZeneca
Affinity DataKi: 14nM ΔG°: -44.4kJ/mole EC50: 23nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
AstraZeneca
AstraZeneca
Affinity DataKi: 15nM ΔG°: -44.2kJ/mole EC50: 19nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
AstraZeneca
AstraZeneca
Affinity DataKi: 33nM ΔG°: -42.3kJ/mole EC50: 41nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
AstraZeneca
AstraZeneca
Affinity DataKi: 48nM ΔG°: -41.4kJ/mole EC50: 81nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
AstraZeneca
AstraZeneca
Affinity DataKi: 50nM ΔG°: -41.3kJ/mole EC50: 130nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
AstraZeneca
AstraZeneca
Affinity DataKi: 70nM ΔG°: -40.4kJ/mole EC50: 250nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
AstraZeneca
AstraZeneca
Affinity DataKi: 94nM ΔG°: -39.7kJ/mole EC50: 220nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
AstraZeneca
AstraZeneca
Affinity DataKi: 180nM ΔG°: -38.1kJ/mole EC50: 150nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
AstraZeneca
AstraZeneca
Affinity DataKi: 200nM ΔG°: -37.9kJ/mole EC50: 270nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
AstraZeneca
AstraZeneca
Affinity DataKi: 220nM ΔG°: -37.6kJ/mole EC50: 750nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
AstraZeneca
AstraZeneca
Affinity DataKi: 480nM ΔG°: -35.7kJ/mole EC50: 1.70E+3nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
AstraZeneca
AstraZeneca
Affinity DataKi: 840nM ΔG°: -34.3kJ/mole EC50: 600nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940](Rattus norvegicus (rat))
AstraZeneca
AstraZeneca
Affinity DataKi: 2.10E+3nM ΔG°: -32.1kJ/mole EC50: 1.10E+3nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataIC50: 0.610nMAssay Description:Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against purified dihydrofolate reductase from ratMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 9.90nMAssay Description:Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.More data for this Ligand-Target Pair
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cellsMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cellsMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.More data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibitory activity against purified dihydrofolate reductase from ratMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Toxoplasma gondiiMore data for this Ligand-Target Pair
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibitory activity against purified dihydrofolate reductase from ratMore data for this Ligand-Target Pair
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibitory activity against purified dihydrofolate reductase from Pneumocystis carinii.More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibitory activity against purified dihydrofolate reductase from ratMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 54nMAssay Description:Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibitory activity against purified dihydrofolate reductase from ratMore data for this Ligand-Target Pair
Affinity DataIC50: 71nMAssay Description:Inhibitory activity against purified dihydrofolate reductase from ratMore data for this Ligand-Target Pair
Affinity DataIC50: 74nMAssay Description:Inhibitory activity against purified dihydrofolate reductase from ratMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 78nMAssay Description:Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
Affinity DataIC50: 95nMAssay Description:Inhibitory activity against purified dihydrofolate reductase from Pneumocystis carinii.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 97nMAssay Description:Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibitory activity against purified dihydrofolate reductase from Pneumocystis carinii.More data for this Ligand-Target Pair
Affinity DataIC50: 109nMAssay Description:Inhibitory activity against purified DHFR (Dihydrofolate reductase) from ratMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.More data for this Ligand-Target Pair
Affinity DataIC50: 114nMAssay Description:Inhibitory activity against purified dihydrofolate reductase from Pneumocystis carinii.More data for this Ligand-Target Pair