Compile Data Set for Download or QSAR
Found 836 with Last Name = 'ledeboer' and Initial = 'm'
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50300196(10-(4-hydroxyphenyl)-8,13,15-triazatetracyclo[9.6....)copy SMILEScopy InChI
Affinity DataKi:  0.00100nMAssay Description:Inhibition of recombinant JAK2Checked by AuthorMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50093352(CHEMBL3586678)copy SMILEScopy InChI
Affinity DataKi:  0.00200nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89F53PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50093351(CHEMBL3585362)copy SMILEScopy InChI
Affinity DataKi:  0.00300nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89F53PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50093355(CHEMBL3586677)copy SMILEScopy InChI
Affinity DataKi:  0.00300nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89F53PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50300196(10-(4-hydroxyphenyl)-8,13,15-triazatetracyclo[9.6....)copy SMILEScopy InChI
Affinity DataKi:  0.00500nMAssay Description:Inhibition of recombinant JAK3Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0TK0PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50300196(10-(4-hydroxyphenyl)-8,13,15-triazatetracyclo[9.6....)copy SMILEScopy InChI
Affinity DataKi:  0.00500nMAssay Description:Inhibition of recombinant JAK3Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0TK0PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50093356(CHEMBL3586676)copy SMILEScopy InChI
Affinity DataKi:  0.00600nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89F53PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50093354(CHEMBL3586679)copy SMILEScopy InChI
Affinity DataKi:  0.00900nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89F53PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50093395(CHEMBL3586674)copy SMILEScopy InChI
Affinity DataKi:  0.0100nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89F53PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50093417(CHEMBL3586672)copy SMILEScopy InChI
Affinity DataKi:  0.0110nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89F53PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50093437(CHEMBL3586668)copy SMILEScopy InChI
Affinity DataKi:  0.0130nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89F53PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50093399(CHEMBL3586673)copy SMILEScopy InChI
Affinity DataKi:  0.0160nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89F53PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50093434(CHEMBL3586670)copy SMILEScopy InChI
Affinity DataKi:  0.0170nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50093436(CHEMBL3586669)copy SMILEScopy InChI
Affinity DataKi:  0.0240nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89F53PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50093353(CHEMBL3586680)copy SMILEScopy InChI
Affinity DataKi:  0.0250nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89F53PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50093391(CHEMBL3586675)copy SMILEScopy InChI
Affinity DataKi:  0.0340nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89F53PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50093439(CHEMBL3586666)copy SMILEScopy InChI
Affinity DataKi:  0.0480nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50093419(CHEMBL3586671)copy SMILEScopy InChI
Affinity DataKi:  0.0660nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89F53PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50093440(CHEMBL3586665)copy SMILEScopy InChI
Affinity DataKi:  0.157nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89F53PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50093438(CHEMBL3586667)copy SMILEScopy InChI
Affinity DataKi:  0.330nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89F53PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50305149(2-fluoro-4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}...)copy SMILEScopy InChI
Affinity DataKi:  0.5nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95RQPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50305150(3-fluoro-4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}...)copy SMILEScopy InChI
Affinity DataKi:  0.600nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95RQPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50305157(3-chloro-4-{8,12,14,16-tetraazatetracyclo[8.6.1.0^...)copy SMILEScopy InChI
Affinity DataKi:  0.800nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95RQPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50305155(3-fluoro-4-{8,12,14,16-tetraazatetracyclo[8.6.1.0^...)copy SMILEScopy InChI
Affinity DataKi:  1nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95RQPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50305156(2-fluoro-4-{8,12,14,16-tetraazatetracyclo[8.6.1.0^...)copy SMILEScopy InChI
Affinity DataKi:  1nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95RQPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50305148(4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,17...)copy SMILEScopy InChI
Affinity DataKi:  1.60nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95RQPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50305153(2-bromo-4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}....)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95RQPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50305154((4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,1...)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95RQPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50305152(3-chloro-4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}...)copy SMILEScopy InChI
Affinity DataKi:  4nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95RQPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50378535(CHEMBL1204012)copy SMILEScopy InChI
Affinity DataKi:  7nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50305151((4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,1...)copy SMILEScopy InChI
Affinity DataKi:  13nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95RQPubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50300196(10-(4-hydroxyphenyl)-8,13,15-triazatetracyclo[9.6....)copy SMILEScopy InChI
Affinity DataKi:  17nMAssay Description:Inhibition of ALKChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0TK0PubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50067514(CHEMBL3401978)copy SMILEScopy InChI
Affinity DataKi:  23nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40WW5PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50305193(CHEMBL589387 | Methyl 9-(3-fluoro-4-hydroxyphenyl)...)copy SMILEScopy InChI
Affinity DataKi:  29nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95RQPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50297454(1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3...)copy SMILEScopy InChI
Affinity DataKi:  30nMAssay Description:Inhibition of p38alpha by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76CMZPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50305196(10-(2-fluoro-4-hydroxyphenyl)-9,13,15-triazatetrac...)copy SMILEScopy InChI
Affinity DataKi:  34nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95RQPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50305178(9-(4-methoxyphenyl)-8,12,14-triazatetracyclo[8.6.1...)copy SMILEScopy InChI
Affinity DataKi:  42nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95RQPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50305175(9-(2,3,6-trifluorophenyl)-8,12,14-triazatetracyclo...)copy SMILEScopy InChI
Affinity DataKi:  56nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95RQPubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50067515(CHEMBL3401979)copy SMILEScopy InChI
Affinity DataKi:  60nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40WW5PubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50067537(CHEMBL3401987)copy SMILEScopy InChI
Affinity DataKi:  66nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40WW5PubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50297455(1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3...)copy SMILEScopy InChI
Affinity DataKi:  70nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76CMZPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50305179(4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,17...)copy SMILEScopy InChI
Affinity DataKi:  71nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95RQPubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50067540(CHEMBL3401990)copy SMILEScopy InChI
Affinity DataKi:  77nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40WW5PubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50067533(CHEMBL3401984)copy SMILEScopy InChI
Affinity DataKi:  78nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40WW5PubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50067531(CHEMBL3401983)copy SMILEScopy InChI
Affinity DataKi:  85nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40WW5PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50297455(1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3...)copy SMILEScopy InChI
Affinity DataKi:  90nMAssay Description:Inhibition of JNK3 by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76CMZPubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50297456(6-bromo-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)m...)copy SMILEScopy InChI
Affinity DataKi:  100nMAssay Description:Inhibition of JNK3 by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76CMZPubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50067513(CHEMBL3401977)copy SMILEScopy InChI
Affinity DataKi:  120nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40WW5PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50305173(9-(2,6-difluorophenyl)-8,12,14-triazatetracyclo[8....)copy SMILEScopy InChI
Affinity DataKi:  130nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95RQPubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50297457(1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3...)copy SMILEScopy InChI
Affinity DataKi:  140nMAssay Description:Inhibition of JNK3 by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76CMZPubMed
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