BindingDB PrimarySearch

Found 126 with Last Name = 'prentiss' and Initial = 'm'

Complement factor D(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50524347(CHEMBL4535197)copy SMILEScopy InChI

IC50: 3nMAssay Description:Inhibition of 2-((1E,3E,5E)-5-(1-(6-((((3S,5S)-1-((1-carbamoyl-1H-indol-3-yl)carbamoyl)-5-((3-chloro-2-fluorobenzyl)carbamoyl)-3-fluoropyrrolidin-3-y...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2CC144NPubMed

Complement factor D(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50462108(CHEMBL4246585)copy SMILEScopy InChI

IC50: 5nMAssay Description:Inhibition of 2-((1E,3E,5E)-5-(1-(6-((((3S,5S)-1-((1-carbamoyl-1H-indol-3-yl)carbamoyl)-5-((3-chloro-2-fluorobenzyl)carbamoyl)-3-fluoropyrrolidin-3-y...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2CC144NPubMed

Complement factor B(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50540314(CHEMBL4639592)copy SMILEScopy InChI

IC50: 6nMAssay Description:Inhibition of human serine protease factor B by TR-FRET based competition binding assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Complement factor D(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50524338(CHEMBL4468000)copy SMILEScopy InChI

IC50: 8nMAssay Description:Inhibition of 2-((1E,3E,5E)-5-(1-(6-((((3S,5S)-1-((1-carbamoyl-1H-indol-3-yl)carbamoyl)-5-((3-chloro-2-fluorobenzyl)carbamoyl)-3-fluoropyrrolidin-3-y...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2CC144NPubMed

Complement factor D(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50524344(CHEMBL4584532)copy SMILEScopy InChI

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BindingDB Entry DOI: 10.7270/Q2CC144NPubMed

Complement factor D(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50524340(CHEMBL4483713)copy SMILEScopy InChI

IC50: 10nMAssay Description:Inhibition of 2-((1E,3E,5E)-5-(1-(6-((((3S,5S)-1-((1-carbamoyl-1H-indol-3-yl)carbamoyl)-5-((3-chloro-2-fluorobenzyl)carbamoyl)-3-fluoropyrrolidin-3-y...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2CC144NPubMed

Complement factor B(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM160475(US10093663, Example 26b | US20240109861, Compound ...)copy SMILES

IC50: 12nMAssay Description:Inhibition of human serine protease factor B by TR-FRET based competition binding assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Complement factor D(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50524346(CHEMBL4548070)copy SMILEScopy InChI

IC50: 12nMAssay Description:Inhibition of 2-((1E,3E,5E)-5-(1-(6-((((3S,5S)-1-((1-carbamoyl-1H-indol-3-yl)carbamoyl)-5-((3-chloro-2-fluorobenzyl)carbamoyl)-3-fluoropyrrolidin-3-y...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2CC144NPubMed PDB

3D Structure (crystal)

Complement factor D(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50524344(CHEMBL4584532)copy SMILEScopy InChI

IC50: 13nMAssay Description:Inhibition of FD-mediated alternative complementation pathway in 50% human whole blood assessed as reduction in zymosan-induced membrane-attack compl...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2CC144NPubMed

Complement factor D(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50524339(CHEMBL4463116)copy SMILEScopy InChI

IC50: 15nMAssay Description:Inhibition of 2-((1E,3E,5E)-5-(1-(6-((((3S,5S)-1-((1-carbamoyl-1H-indol-3-yl)carbamoyl)-5-((3-chloro-2-fluorobenzyl)carbamoyl)-3-fluoropyrrolidin-3-y...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2CC144NPubMed

Complement factor B(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50540312(CHEMBL4641109)copy SMILEScopy InChI

IC50: 18nMAssay Description:Inhibition of human serine protease factor B by TR-FRET based competition binding assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Complement factor B(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50540313(CHEMBL4644208)copy SMILEScopy InChI

IC50: 18nMAssay Description:Inhibition of human serine protease factor B by TR-FRET based competition binding assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Complement factor B(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM160036(US10093663, Example 21a | US9682968, Example-21a)copy SMILES

IC50: 18nMAssay Description:Inhibition of human serine protease factor B by TR-FRET based competition binding assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Complement factor D(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50524340(CHEMBL4483713)copy SMILEScopy InChI

IC50: 20nMAssay Description:Inhibition of FD-mediated alternative complementation pathway in 50% human whole blood assessed as reduction in zymosan-induced membrane-attack compl...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2CC144NPubMed

Complement factor D(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50524349(CHEMBL4554970)copy SMILEScopy InChI

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BindingDB Entry DOI: 10.7270/Q2CC144NPubMed

Complement factor B(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50540311(CHEMBL4646504)copy SMILEScopy InChI

IC50: 24nMAssay Description:Inhibition of human serine protease factor B by TR-FRET based competition binding assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Complement factor D(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50524342(CHEMBL4516604)copy SMILEScopy InChI

IC50: 25nMAssay Description:Inhibition of 2-((1E,3E,5E)-5-(1-(6-((((3S,5S)-1-((1-carbamoyl-1H-indol-3-yl)carbamoyl)-5-((3-chloro-2-fluorobenzyl)carbamoyl)-3-fluoropyrrolidin-3-y...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2CC144NPubMed

Complement factor D(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50524349(CHEMBL4554970)copy SMILEScopy InChI

IC50: 30nMAssay Description:Inhibition of 2-((1E,3E,5E)-5-(1-(6-((((3S,5S)-1-((1-carbamoyl-1H-indol-3-yl)carbamoyl)-5-((3-chloro-2-fluorobenzyl)carbamoyl)-3-fluoropyrrolidin-3-y...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2CC144NPubMed

Complement factor D(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50524343(CHEMBL4546264)copy SMILEScopy InChI

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BindingDB Entry DOI: 10.7270/Q2CC144NPubMed

Complement factor B(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM160473(US10093663, Example 25b | US9682968, Example-25a (...)copy SMILES

IC50: 62nMAssay Description:Inhibition of human serine protease factor B by TR-FRET based competition binding assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Complement factor B(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM160473(US10093663, Example 25b | US9682968, Example-25a (...)copy SMILES

IC50: 62nMAssay Description:Inhibition of human serine protease factor B by TR-FRET based competition binding assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Complement factor D(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50524339(CHEMBL4463116)copy SMILEScopy InChI

IC50: 70nMAssay Description:Inhibition of FD-mediated alternative complementation pathway in 50% human whole blood assessed as reduction in zymosan-induced membrane-attack compl...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2CC144NPubMed

Complement factor D(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50462108(CHEMBL4246585)copy SMILEScopy InChI

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BindingDB Entry DOI: 10.7270/Q2CC144NPubMed

Complement factor B(Mus musculus)
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50540314(CHEMBL4639592)copy SMILEScopy InChI

IC50: 80nMAssay Description:Inhibition of serine protease factor B in 50% mouse serum assessed as reduction in C3b deposition pre-incubated for 15 mins before activated zymosan ...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Complement factor B(Mus musculus)
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM160475(US10093663, Example 26b | US20240109861, Compound ...)copy SMILES

IC50: 110nMAssay Description:Inhibition of serine protease factor B in 50% mouse serum assessed as reduction in C3b deposition pre-incubated for 15 mins before activated zymosan ...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Complement factor B(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50540313(CHEMBL4644208)copy SMILEScopy InChI

IC50: 110nMAssay Description:Inhibition of serine protease factor B in 50% human whole blood assessed as reduction in alternative pathway-mediated membrane attack complex formati...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Complement factor B(Mus musculus)
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50540313(CHEMBL4644208)copy SMILEScopy InChI

IC50: 120nMAssay Description:Inhibition of serine protease factor B in 50% mouse serum assessed as reduction in C3b deposition pre-incubated for 15 mins before activated zymosan ...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Complement factor B(Mus musculus)
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50540312(CHEMBL4641109)copy SMILEScopy InChI

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BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Complement factor D(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50524345(CHEMBL4475961)copy SMILEScopy InChI

IC50: 120nMAssay Description:Inhibition of 2-((1E,3E,5E)-5-(1-(6-((((3S,5S)-1-((1-carbamoyl-1H-indol-3-yl)carbamoyl)-5-((3-chloro-2-fluorobenzyl)carbamoyl)-3-fluoropyrrolidin-3-y...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2CC144NPubMed PDB

3D Structure (crystal)

Complement factor B(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM160475(US10093663, Example 26b | US20240109861, Compound ...)copy SMILES

IC50: 130nMAssay Description:Inhibition of serine protease factor B in 50% human whole blood assessed as reduction in alternative pathway-mediated membrane attack complex formati...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Complement factor B(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50540314(CHEMBL4639592)copy SMILEScopy InChI

IC50: 140nMAssay Description:Inhibition of serine protease factor B in 50% human whole blood assessed as reduction in alternative pathway-mediated membrane attack complex formati...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Complement factor B(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50540311(CHEMBL4646504)copy SMILEScopy InChI

IC50: 150nMAssay Description:Inhibition of serine protease factor B in 50% human whole blood assessed as reduction in alternative pathway-mediated membrane attack complex formati...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Complement factor B(Mus musculus)
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM160036(US10093663, Example 21a | US9682968, Example-21a)copy SMILES

IC50: 150nMAssay Description:Inhibition of serine protease factor B in 50% mouse serum assessed as reduction in C3b deposition pre-incubated for 15 mins before activated zymosan ...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Complement factor D(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50524347(CHEMBL4535197)copy SMILEScopy InChI

IC50: 160nMAssay Description:Inhibition of FD-mediated alternative complementation pathway in 50% human whole blood assessed as reduction in zymosan-induced membrane-attack compl...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2CC144NPubMed

Complement factor B(Mus musculus)
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50540311(CHEMBL4646504)copy SMILEScopy InChI

IC50: 160nMAssay Description:Inhibition of serine protease factor B in 50% mouse serum assessed as reduction in C3b deposition pre-incubated for 15 mins before activated zymosan ...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Alpha-2C adrenergic receptor(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50540286(CHEMBL4636550)copy SMILEScopy InChI

IC50: 180nMAssay Description:Inhibition of adrenergic receptor alpha2c (unknown origin)More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Complement factor B(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM160036(US10093663, Example 21a | US9682968, Example-21a)copy SMILES

IC50: 180nMAssay Description:Inhibition of serine protease factor B in 50% human whole blood assessed as reduction in alternative pathway-mediated membrane attack complex formati...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Complement factor B(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50540312(CHEMBL4641109)copy SMILEScopy InChI

IC50: 240nMAssay Description:Inhibition of serine protease factor B in 50% human whole blood assessed as reduction in alternative pathway-mediated membrane attack complex formati...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Complement factor B(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM160473(US10093663, Example 25b | US9682968, Example-25a (...)copy SMILES

IC50: 250nMAssay Description:Inhibition of serine protease factor B in 50% human whole blood assessed as reduction in alternative pathway-mediated membrane attack complex formati...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Complement factor D(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50524346(CHEMBL4548070)copy SMILEScopy InChI

IC50: 260nMAssay Description:Inhibition of FD-mediated alternative complementation pathway in 50% human whole blood assessed as reduction in zymosan-induced membrane-attack compl...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2CC144NPubMed PDB

3D Structure (crystal)

Complement factor D(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50524338(CHEMBL4468000)copy SMILEScopy InChI

IC50: 270nMAssay Description:Inhibition of FD-mediated alternative complementation pathway in 50% human whole blood assessed as reduction in zymosan-induced membrane-attack compl...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2CC144NPubMed

Complement factor D(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50524350(CHEMBL4465159)copy SMILEScopy InChI

IC50: 270nMAssay Description:Inhibition of 2-((1E,3E,5E)-5-(1-(6-((((3S,5S)-1-((1-carbamoyl-1H-indol-3-yl)carbamoyl)-5-((3-chloro-2-fluorobenzyl)carbamoyl)-3-fluoropyrrolidin-3-y...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2CC144NPubMed

Alpha-1A adrenergic receptor(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50540286(CHEMBL4636550)copy SMILEScopy InChI

IC50: 300nMAssay Description:Inhibition of adrenergic receptor alpha1a (unknown origin)More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Tryptase beta-2(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50524338(CHEMBL4468000)copy SMILEScopy InChI

IC50: 350nMAssay Description:Inhibition of tryptase-beta2 (unknown origin)More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2CC144NPubMed

Complement factor B(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM160475(US10093663, Example 26b | US20240109861, Compound ...)copy SMILES

IC50: 400nMAssay Description:Inhibition of human serine protease factor B in human PNH patient derived sample assessed as prevention of erythrocyte lysisMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Coagulation factor XI(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50524338(CHEMBL4468000)copy SMILEScopy InChI

IC50: 600nMAssay Description:Inhibition of F11a (unknown origin)More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2CC144NPubMed

Coagulation factor XI(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50524344(CHEMBL4584532)copy SMILEScopy InChI

IC50: 650nMAssay Description:Inhibition of F11a (unknown origin)More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2CC144NPubMed

Complement factor D(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50524343(CHEMBL4546264)copy SMILEScopy InChI

IC50: 700nMAssay Description:Inhibition of FD-mediated alternative complementation pathway in 50% human whole blood assessed as reduction in zymosan-induced membrane-attack compl...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2CC144NPubMed

Complement factor B(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM159294(US10093663, Example 8 | US9682968, Example-8)copy SMILES

IC50: 710nMAssay Description:Inhibition of human serine protease factor B by TR-FRET based competition binding assayMore data for this Ligand-Target Pair

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Details Article
BindingDB Entry DOI: 10.7270/Q21N84P4PubMed

Urokinase-type plasminogen activator(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL

BDBM50524338(CHEMBL4468000)copy SMILEScopy InChI

IC50: 770nMAssay Description:Inhibition of urokinase (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article
BindingDB Entry DOI: 10.7270/Q2CC144NPubMed

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