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Found 112 with Last Name = 'vanejevs' and Initial = 'm'
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231755(6,6-dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinol...)copy SMILEScopy InChI
Affinity DataKi:  51nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231728(5-methoxy-2-phenylethynyl-5,6,7,8-tetrahydro-quino...)copy SMILEScopy InChI
Affinity DataKi:  139nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231738(7,7-dimethyl-2-pyridin-2-ylethynyl-7,8-dihydro-6H-...)copy SMILEScopy InChI
Affinity DataKi:  210nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231741(2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one | CH...)copy SMILEScopy InChI
Affinity DataKi:  800nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231751(6-phenylethynyl-nicotinic acid methyl ester | CHEM...)copy SMILEScopy InChI
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231753(2-phenylethynyl-5,6,7,8-tetrahydro-quinoline | CHE...)copy SMILEScopy InChI
Affinity DataKi:  1.50E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231721(2-pyridin-2-ylethynyl-7,8-dihydro-6H-quinolin-5-on...)copy SMILEScopy InChI
Affinity DataKi:  2.36E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231747((R)-2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-...)copy SMILEScopy InChI
Affinity DataKi:  4.71E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231719(2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-ol |...)copy SMILEScopy InChI
Affinity DataKi:  7.60E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231759((S)-2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-...)copy SMILEScopy InChI
Affinity DataKi:  9.28E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231750((3-ethyl-2-methylquinolin-6-yl)(4-methoxycyclohexy...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231744(CHEMBL399160 | NPS 2390 | quinoxaline-2-carboxylic...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231749(6-ethyl-5-methyl-3-(1,2,4,5-tetrahydrobenzo[d]azep...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50231755(6,6-dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinol...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231755(6,6-dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinol...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50438277(CHEMBL2408412)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50438295(CHEMBL2408568)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50438289(CHEMBL2408574)copy SMILEScopy InChI
Affinity DataIC50: 43nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231748(CHEMBL253347 | quinoline-3-carboxylic acid adamant...)copy SMILEScopy InChI
Affinity DataIC50: 52nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50438278(CHEMBL2408411)copy SMILEScopy InChI
Affinity DataIC50: 68nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231758(2-cyclopentylamino-7,7-dimethyl-5-oxo-5,6,7,8-tetr...)copy SMILEScopy InChI
Affinity DataIC50: 78nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231728(5-methoxy-2-phenylethynyl-5,6,7,8-tetrahydro-quino...)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50438294(CHEMBL2408569)copy SMILEScopy InChI
Affinity DataIC50: 83nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50438298(CHEMBL2408565)copy SMILEScopy InChI
Affinity DataIC50: 85nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231757(2-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50438288(CHEMBL2408575)copy SMILEScopy InChI
Affinity DataIC50: 111nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50438305(CHEMBL2408585)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50438291(CHEMBL2408572)copy SMILEScopy InChI
Affinity DataIC50: 125nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231743(7,7-dimethyl-5-oxo-2-(4-phenyl-piperazin-1-yl)-5,6...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50438293(CHEMBL2408570)copy SMILEScopy InChI
Affinity DataIC50: 157nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231764(2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-7,7-dimethy...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50438298(CHEMBL2408565)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50438298(CHEMBL2408565)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50438300(CHEMBL2408563)copy SMILEScopy InChI
Affinity DataIC50: 245nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50438303(CHEMBL2408561)copy SMILEScopy InChI
Affinity DataIC50: 272nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231752(CHEMBL399161 | quinoline-2-carboxylic acid adamant...)copy SMILEScopy InChI
Affinity DataIC50: 440nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50438281(CHEMBL2408408)copy SMILEScopy InChI
Affinity DataIC50: 452nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50438301(CHEMBL1389853)copy SMILEScopy InChI
Affinity DataIC50: 492nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50438299(CHEMBL2408564)copy SMILEScopy InChI
Affinity DataIC50: 493nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50438309(CHEMBL2408582)copy SMILEScopy InChI
Affinity DataIC50: 496nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231753(2-phenylethynyl-5,6,7,8-tetrahydro-quinoline | CHE...)copy SMILEScopy InChI
Affinity DataIC50: 510nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50438292(CHEMBL2408571)copy SMILEScopy InChI
Affinity DataIC50: 598nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50438290(CHEMBL2408573)copy SMILEScopy InChI
Affinity DataIC50: 721nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50438304(CHEMBL2408413)copy SMILEScopy InChI
Affinity DataIC50: 722nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50003013(CHEMBL401270)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC04B2PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50438283(CHEMBL2408406)copy SMILEScopy InChI
Affinity DataIC50: 1.04E+3nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50438286(CHEMBL2408577)copy SMILEScopy InChI
Affinity DataIC50: 1.12E+3nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals GmbH

Curated by ChEMBL
LigandPNGBDBM50438287(CHEMBL2408576)copy SMILEScopy InChI
Affinity DataIC50: 1.13E+3nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20B8PubMed
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