Compile Data Set for Download or QSAR
Found 212 with Last Name = 'voets' and Initial = 'm'
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8891(3-(6-Methoxy-3,4-dihydronaphthalen-2-yl)pyridine |...)copy SMILEScopy InChI
Affinity DataKi:  1.30nM IC50: 2nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MW2FBSPubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8890(3-(5-Methoxy-1H-inden-2-yl)pyridine | indene 3)copy SMILEScopy InChI
Affinity DataKi:  2.60nM IC50: 4nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MW2FBSPubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8889(3-(3,4-Dihydronaphthalen-2-yl)pyridine | Dihydrona...)copy SMILEScopy InChI
Affinity DataKi:  4.60nM IC50: 7nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MW2FBSPubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8888(3-(1H-Inden-2-yl)pyridine | US9271963, 32 | indene...)copy SMILEScopy InChI
Affinity DataKi:  8.40nM IC50: 13nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MW2FBSPubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8611(4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...)copy SMILEScopy InChI
Affinity DataIC50: 1nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8611(4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...)copy SMILEScopy InChI
Affinity DataIC50: 1nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8611(4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...)copy SMILEScopy InChI
Affinity DataIC50: 1nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8611(4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...)copy SMILEScopy InChI
Affinity DataIC50: 1nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8891(3-(6-Methoxy-3,4-dihydronaphthalen-2-yl)pyridine |...)copy SMILEScopy InChI
Affinity DataIC50: 2nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KBNUS Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8909(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41PNTPubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8909(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)copy SMILEScopy InChI
Affinity DataIC50: 3nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KBNUS Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM220126(US9271963, 34)copy SMILEScopy InChI
Affinity DataIC50: 4nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KBNUS Patent
TargetAromatase(Homo sapiens (Human))
UNIVERSITAT DES SAARLANDES

US Patent
LigandPNGBDBM8889(3-(3,4-Dihydronaphthalen-2-yl)pyridine | Dihydrona...)copy SMILEScopy InChI
Affinity DataIC50: 4.07nMpH: 7.4Assay Description:The enzyme was obtained from the microsome fraction of fresh human placenta (St. Josephs Krankenhaus, Saarbrucken-Dudweiler, Germany) according to th...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KBNUS Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8894(3-(3-Methyl-3,4-dihydronaphthalen-2-yl)pyridine | ...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MW2FBSPubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8894(3-(3-Methyl-3,4-dihydronaphthalen-2-yl)pyridine | ...)copy SMILEScopy InChI
Affinity DataIC50: 5nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KBNUS Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8905(3-(6-Methoxy-2-naphthyl)pyridine | 3-(6-methoxynap...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41PNTPubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8905(3-(6-Methoxy-2-naphthyl)pyridine | 3-(6-methoxynap...)copy SMILEScopy InChI
Affinity DataIC50: 6nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KBNUS Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8905(3-(6-Methoxy-2-naphthyl)pyridine | 3-(6-methoxynap...)copy SMILEScopy InChI
Affinity DataIC50: 6.20nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KBNUS Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8892(3-(1-Methyl-3,4-dihydronaphthalen-2-yl)-pyridine |...)copy SMILEScopy InChI
Affinity DataIC50: 7nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KBNUS Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8889(3-(3,4-Dihydronaphthalen-2-yl)pyridine | Dihydrona...)copy SMILEScopy InChI
Affinity DataIC50: 7nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KBNUS Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8892(3-(1-Methyl-3,4-dihydronaphthalen-2-yl)-pyridine |...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MW2FBSPubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
UNIVERSITAT DES SAARLANDES

US Patent
LigandPNGBDBM8611(4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...)copy SMILEScopy InChI
Affinity DataIC50: 9nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
UNIVERSITAT DES SAARLANDES

US Patent
LigandPNGBDBM8611(4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...)copy SMILEScopy InChI
Affinity DataIC50: 9.70nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
UNIVERSITAT DES SAARLANDES

US Patent
LigandPNGBDBM8611(4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...)copy SMILEScopy InChI
Affinity DataIC50: 10nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM9921(3-(1,2-dihydroacenaphthylen-3-yl)pyridine | acenap...)copy SMILEScopy InChI
Affinity DataIC50: 10nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F18WXWPubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
UNIVERSITAT DES SAARLANDES

US Patent
LigandPNGBDBM8611(4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...)copy SMILEScopy InChI
Affinity DataIC50: 10nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
UNIVERSITAT DES SAARLANDES

US Patent
LigandPNGBDBM8611(4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...)copy SMILEScopy InChI
Affinity DataIC50: 10nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8908(3-(6-Ethoxy-2-naphthyl)pyridine | 3-(6-ethoxynapht...)copy SMILEScopy InChI
Affinity DataIC50: 12nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KBNUS Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8908(3-(6-Ethoxy-2-naphthyl)pyridine | 3-(6-ethoxynapht...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41PNTPubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8932(1-Methyl-5-(2-naphthyl)-1H-imidazole | 1-methyl-5-...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41PNTPubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8910(3-(5-Chloro-6-methoxy-2-naphthyl)pyridine | 3-(5-c...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41PNTPubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8895(3-(4-Methyl-3,4-dihydronaphthalen-2-yl)pyridine | ...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MW2FBSPubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8910(3-(5-Chloro-6-methoxy-2-naphthyl)pyridine | 3-(5-c...)copy SMILEScopy InChI
Affinity DataIC50: 13nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KBNUS Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8895(3-(4-Methyl-3,4-dihydronaphthalen-2-yl)pyridine | ...)copy SMILEScopy InChI
Affinity DataIC50: 13nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KBNUS Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8888(3-(1H-Inden-2-yl)pyridine | US9271963, 32 | indene...)copy SMILEScopy InChI
Affinity DataIC50: 13.5nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KBNUS Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM9922(3-(1,2-dihydroacenaphthylen-5-yl)pyridine | acenap...)copy SMILEScopy InChI
Affinity DataIC50: 14nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F18WXWPubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8907(3-(6-Bromo-2-naphthyl)pyridine | 3-(6-bromonaphtha...)copy SMILEScopy InChI
Affinity DataIC50: 15nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KBNUS Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8907(3-(6-Bromo-2-naphthyl)pyridine | 3-(6-bromonaphtha...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41PNTPubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8611(4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...)copy SMILEScopy InChI
Affinity DataIC50: 18.7nMpH: 7.4 T: 2°CAssay Description:A suspension of fission yeast (S. pombe PE1) with a cell density of 3˙10^7 cells/ml was prepared on a freshly grown culture using fresh EMMG (pH ...More data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8917(1-(3-methoxynaphthalen-2-yl)-1H-imidazole | Imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41PNTPubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8906(6-(pyridin-3-yl)naphthalen-2-ol | 6-Pyridin-3-ylna...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41PNTPubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8906(6-(pyridin-3-yl)naphthalen-2-ol | 6-Pyridin-3-ylna...)copy SMILEScopy InChI
Affinity DataIC50: 23nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KBNUS Patent
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8913(3-(1-Chloro-7-methoxy-2-naphthyl)pyridine | 3-(1-c...)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41PNTPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8913(3-(1-Chloro-7-methoxy-2-naphthyl)pyridine | 3-(1-c...)copy SMILEScopy InChI
Affinity DataIC50: 27nMpH: 7.4 T: 2°CAssay Description:A solution of 6.25 nmol of progesterone (in 5 μl of MeOH) was dissolved in 140 μl of phosphate buffer (0.05 M; pH 7.4; 1 mM MgCl2; 0.1 mM EDTA ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KBNUS Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8904(3-(2-Naphthyl)pyridine | 3-(naphthalen-2-yl)pyridi...)copy SMILEScopy InChI
Affinity DataIC50: 28nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KBNUS Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8912(3-(1,5-Dichloro-6-methoxy-2-naphthyl)pyridine | 3-...)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41PNTPubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8904(3-(2-Naphthyl)pyridine | 3-(naphthalen-2-yl)pyridi...)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41PNTPubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8912(3-(1,5-Dichloro-6-methoxy-2-naphthyl)pyridine | 3-...)copy SMILEScopy InChI
Affinity DataIC50: 28nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KBNUS Patent
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
UNIVERSITAT DES SAARLANDES

US Patent
LigandPNGBDBM8611(4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...)copy SMILEScopy InChI
Affinity DataIC50: 28.3nMpH: 7.4 T: 2°CAssay Description:A suspension of fission yeast (S. pombe PE1) with a cell density of 3˙10^7 cells/ml was prepared on a freshly grown culture using fresh EMMG (pH ...More data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8904(3-(2-Naphthyl)pyridine | 3-(naphthalen-2-yl)pyridi...)copy SMILEScopy InChI
Affinity DataIC50: 28.4nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445KBNUS Patent
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