Compile Data Set for Download or QSAR
Found 30 with Last Name = 'ciufolini' and Initial = 'ma'
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)copy SMILEScopy InChI
Affinity DataIC50: 3.10E+3nMpH: 7.0Assay Description:Inhibition of human placental HexA using MUGS substrate incubated for 1 to 2 hrs at pH 7.0 by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit beta(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)copy SMILEScopy InChI
Affinity DataIC50: 4.50E+3nMpH: 7.0Assay Description:Inhibition of human placental HexB using MUGS substrate incubated for 1 to 2 hrs at pH 7.0 by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)copy SMILEScopy InChI
Affinity DataIC50: 8.50E+3nMpH: 4.5Assay Description:Inhibition of HexA alpha G269S mutant in ATSD patient fibroblasts using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)copy SMILEScopy InChI
Affinity DataIC50: 8.90E+3nMpH: 4.5Assay Description:Inhibition of human placental HexA using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit beta(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)copy SMILEScopy InChI
Affinity DataIC50: 9.10E+3nMpH: 4.5Assay Description:Inhibition of human placental HexB using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM18788(6-ethyl-5-phenylpyrimidine-2,4-diamine | CHEMBL221...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+4nMpH: 7.0Assay Description:Inhibition of human placental HexA using MUGS substrate incubated for 1 to 2 hrs at pH 7.0 by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+4nMpH: 4.5Assay Description:Inhibition of HexA in normal human fibroblasts using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha/beta(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of beta-N-acetylhexosaminidase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit beta(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM18788(6-ethyl-5-phenylpyrimidine-2,4-diamine | CHEMBL221...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+4nMpH: 7.0Assay Description:Inhibition of human placental HexB using MUGS substrate incubated for 1 to 2 hrs at pH 7.0 by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM50089680(CHEMBL3577321)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM18780(6-ethyl-5-(4-methoxyphenyl)pyrimidine-2,4-diamine ...)copy SMILEScopy InChI
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM50089676(CHEMBL3577317)copy SMILEScopy InChI
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM18788(6-ethyl-5-phenylpyrimidine-2,4-diamine | CHEMBL221...)copy SMILEScopy InChI
Affinity DataIC50: 2.70E+4nMpH: 4.5Assay Description:Inhibition of HexA in normal human fibroblasts using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM18788(6-ethyl-5-phenylpyrimidine-2,4-diamine | CHEMBL221...)copy SMILEScopy InChI
Affinity DataIC50: 2.70E+4nMpH: 4.5Assay Description:Inhibition of HexA alpha G269S mutant in ATSD patient fibroblasts using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM18788(6-ethyl-5-phenylpyrimidine-2,4-diamine | CHEMBL221...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMpH: 4.5Assay Description:Inhibition of human placental HexA using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM18788(6-ethyl-5-phenylpyrimidine-2,4-diamine | CHEMBL221...)copy SMILEScopy InChI
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM50089681(CHEMBL3577322)copy SMILEScopy InChI
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit beta(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM18788(6-ethyl-5-phenylpyrimidine-2,4-diamine | CHEMBL221...)copy SMILEScopy InChI
Affinity DataIC50: 3.80E+4nMpH: 4.5Assay Description:Inhibition of human placental HexB using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM18779(6-ethyl-5-(4-methylphenyl)pyrimidine-2,4-diamine |...)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM50089682(CHEMBL3577323)copy SMILEScopy InChI
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM50089683(CHEMBL3577324)copy SMILEScopy InChI
Affinity DataIC50: 4.70E+4nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM50089679(CHEMBL3577320)copy SMILEScopy InChI
Affinity DataIC50: 1.80E+5nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM50089674(CHEMBL3577315)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM50089673(CHEMBL3577314)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM50089677(CHEMBL3577318)copy SMILEScopy InChI
Affinity DataIC50: 4.10E+5nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM18775(5-(4-chlorophenyl)-6-methylpyrimidine-2,4-diamine ...)copy SMILEScopy InChI
Affinity DataIC50: 5.60E+5nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM50089675(CHEMBL3577316)copy SMILEScopy InChI
Affinity DataIC50: 9.40E+5nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM50089678(CHEMBL3577319)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+6nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Curated by ChEMBL
LigandPNGBDBM50089672(CHEMBL3577313)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+6nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054CKPubMed