TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 4.20nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of EGFR in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q25M69BVPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q25M69BVPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of EGFR in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of HDAC8 in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 54nMAssay Description:Inhibition of human HER2 in human A549 cells by ELISA methodMore data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Inhibition of NFkappaB p65 in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 57nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR (695 to end) expressed in baculovirus infected Sf9 cells using ATP as substrate after 40 m...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 64nMAssay Description:Inhibition of human HER2 in human A549 cells by ELISA methodMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 64nMAssay Description:Inhibition of human HER2 in human A549 cells by ELISA methodMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR (695 to end) expressed in baculovirus infected Sf9 cells using ATP as substrate after 40 m...More data for this Ligand-Target Pair
Affinity DataIC50: 72nMAssay Description:Inhibition of HDAC8 in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 84nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR (695 to end) expressed in baculovirus infected Sf9 cells using ATP as substrate after 40 m...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 87nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 94nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 96nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 96nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 104nMAssay Description:Inhibition of human HER2 in human A549 cells by ELISA methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 105nMAssay Description:Inhibition of VEGFR2 in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of ovine COX2 using arachidonic acid as substrate incubated for 5 mins followed by substrate addition measured after 2 mins by colorimetri...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 113nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 115nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
Affinity DataIC50: 134nMAssay Description:Inhibition of NFkappaB p65 in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 147nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR (695 to end) expressed in baculovirus infected Sf9 cells using ATP as substrate after 40 m...More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of ovine COX1 assessed as PGF2alpha production from PGH2 after 5 mins by enzyme immunoassayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of ovine COX1 by enzyme immuno assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 221nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Kyushu Institute of Technology1-1 Sensuicho
Curated by ChEMBL
Kyushu Institute of Technology1-1 Sensuicho
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of DNA topoisomerase 2 in human MCF7 cells incubated for 18 to 24 hrs by kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of ovine COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:Inhibition of ovine COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 286nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibition of ovine COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of ovine COX-2 using arachidonic acid as substrate assessed as production of PGH2-alpha preincubated for 5 mins followed by addition of su...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of ovine COX2 assessed as PGF2alpha production from PGH2 after 5 mins by enzyme immunoassayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 302nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 319nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
Affinity DataIC50: 330nMAssay Description:Inhibition of ovine COX2 assessed as reduction in PGF2alpha production using arachidonic acid as substrate preincubated with enzyme for 5 mins follow...More data for this Ligand-Target Pair