Compile Data Set for Download or QSAR
Found 188 with Last Name = 'paige' and Initial = 'ma'
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM397477(US9993465, Sazetidine-A)copy SMILEScopy InChI
Affinity DataKi:  0.0620nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MQ8US Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM50382474(CHEMBL2024096 | US9303017, Sazetidine-A)copy SMILEScopy InChI
Affinity DataKi:  0.0620nM ΔG°:  -54.2kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rattus norvegicus (Rat))
Georgetown University; Duke University

US Patent
LigandPNGBDBM50382474(CHEMBL2024096 | US9303017, Sazetidine-A)copy SMILEScopy InChI
Affinity DataKi:  0.0870nM ΔG°:  -53.4kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM397477(US9993465, Sazetidine-A)copy SMILEScopy InChI
Affinity DataKi:  0.0870nMAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MQ8US Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM50166908(5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca...)copy SMILEScopy InChI
Affinity DataKi:  0.120nMMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM221048(US9284322, varenicline | US9303017, Varenicline)copy SMILEScopy InChI
Affinity DataKi:  0.120nM ΔG°:  -52.6kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Rattus norvegicus (Rat))
BioCryst Pharmaceuticals

LigandPNGBDBM397477(US9993465, Sazetidine-A)copy SMILEScopy InChI
Affinity DataKi:  0.380nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MQ8US Patent
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Rattus norvegicus (Rat))
BioCryst Pharmaceuticals

LigandPNGBDBM50382474(CHEMBL2024096 | US9303017, Sazetidine-A)copy SMILEScopy InChI
Affinity DataKi:  0.380nM ΔG°:  -50.0kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rattus norvegicus (Rat))
Georgetown University; Duke University

US Patent
LigandPNGBDBM221048(US9284322, varenicline | US9303017, Varenicline)copy SMILEScopy InChI
Affinity DataKi:  0.480nM ΔG°:  -49.4kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM50166908(5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca...)copy SMILEScopy InChI
Affinity DataKi:  0.480nMAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.H...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Rattus norvegicus (Rat))
BioCryst Pharmaceuticals

LigandPNGBDBM221048(US9284322, varenicline | US9303017, Varenicline)copy SMILEScopy InChI
Affinity DataKi:  2.5nM ΔG°:  -45.6kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Rattus norvegicus (Rat))
BioCryst Pharmaceuticals

LigandPNGBDBM50166908(5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca...)copy SMILEScopy InChI
Affinity DataKi:  2.5nMMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM50428080(CHEMBL2323571 | US9303017, (S)-22, YL-1-231)copy SMILEScopy InChI
Affinity DataKi:  4.20nM ΔG°:  -44.4kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM50428081(CHEMBL2323570 | US9303017, (S)-17)copy SMILEScopy InChI
Affinity DataKi:  4.30nM ΔG°:  -44.4kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM50428081(CHEMBL2323570 | US9303017, (S)-17)copy SMILEScopy InChI
Affinity DataKi:  4.30nM ΔG°:  -44.4kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM397483(US9993465, (S)-17)copy SMILEScopy InChI
Affinity DataKi:  4.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MQ8US Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM50428086(CHEMBL2323572 | US9303017, (S)-21, YL-1-235)copy SMILEScopy InChI
Affinity DataKi:  4.70nM ΔG°:  -44.2kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM50428080(CHEMBL2323571 | US9303017, (S)-22, YL-1-231)copy SMILEScopy InChI
Affinity DataKi:  5.10nM ΔG°:  -44.0kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM397484(US9993465, (S)-22)copy SMILEScopy InChI
Affinity DataKi:  5.10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MQ8US Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM50428086(CHEMBL2323572 | US9303017, (S)-21, YL-1-235)copy SMILEScopy InChI
Affinity DataKi:  5.30nM ΔG°:  -43.9kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM397485(US9993465, (S)-21)copy SMILEScopy InChI
Affinity DataKi:  5.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MQ8US Patent
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM397483(US9993465, (S)-17)copy SMILEScopy InChI
Affinity DataKi:  5.30nMAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MQ8US Patent
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rattus norvegicus (Rat))
Georgetown University; Duke University

US Patent
LigandPNGBDBM50428081(CHEMBL2323570 | US9303017, (S)-17)copy SMILEScopy InChI
Affinity DataKi:  5.30nM ΔG°:  -43.9kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM397485(US9993465, (S)-21)copy SMILEScopy InChI
Affinity DataKi:  8.60nMAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MQ8US Patent
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rattus norvegicus (Rat))
Georgetown University; Duke University

US Patent
LigandPNGBDBM50428086(CHEMBL2323572 | US9303017, (S)-21, YL-1-235)copy SMILEScopy InChI
Affinity DataKi:  8.60nM ΔG°:  -42.8kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM397484(US9993465, (S)-22)copy SMILEScopy InChI
Affinity DataKi:  8.70nMAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MQ8US Patent
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rattus norvegicus (Rat))
Georgetown University; Duke University

US Patent
LigandPNGBDBM50428080(CHEMBL2323571 | US9303017, (S)-22, YL-1-231)copy SMILEScopy InChI
Affinity DataKi:  8.70nM ΔG°:  -42.8kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM397482(US9993465, (S)-27)copy SMILEScopy InChI
Affinity DataKi:  9.60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MQ8US Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM50428079(CHEMBL2323569 | US9303017, 25, YL-1-199)copy SMILEScopy InChI
Affinity DataKi:  9.60nM ΔG°:  -42.5kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM50428079(CHEMBL2323569 | US9303017, 25, YL-1-199)copy SMILEScopy InChI
Affinity DataKi:  9.60nM ΔG°:  -42.5kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)copy SMILEScopy InChI
Affinity DataKi:  10nM ΔG°:  -42.4kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rattus norvegicus (Rat))
Georgetown University; Duke University

US Patent
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)copy SMILEScopy InChI
Affinity DataKi:  12nM ΔG°:  -42.0kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM50428085(CHEMBL2323566 | US9303017, (S)-15, YL-1-127)copy SMILEScopy InChI
Affinity DataKi:  12nM ΔG°:  -42.0kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.H...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM397478(US9993465, (R)-15 | US9993465, (S)-15)copy SMILEScopy InChI
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MQ8US Patent
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM397482(US9993465, (S)-27)copy SMILEScopy InChI
Affinity DataKi:  13nMAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MQ8US Patent
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rattus norvegicus (Rat))
Georgetown University; Duke University

US Patent
LigandPNGBDBM50428079(CHEMBL2323569 | US9303017, 25, YL-1-199)copy SMILEScopy InChI
Affinity DataKi:  13nM ΔG°:  -41.8kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM397478(US9993465, (R)-15 | US9993465, (S)-15)copy SMILEScopy InChI
Affinity DataKi:  16nMAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MQ8US Patent
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rattus norvegicus (Rat))
Georgetown University; Duke University

US Patent
LigandPNGBDBM50428085(CHEMBL2323566 | US9303017, (S)-15, YL-1-127)copy SMILEScopy InChI
Affinity DataKi:  16nM ΔG°:  -41.4kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rattus norvegicus (Rat))
Georgetown University; Duke University

US Patent
LigandPNGBDBM221048(US9284322, varenicline | US9303017, Varenicline)copy SMILEScopy InChI
Affinity DataKi:  28nM ΔG°:  -40.1kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Georgetown University; Duke University

US Patent
LigandPNGBDBM221048(US9284322, varenicline | US9303017, Varenicline)copy SMILEScopy InChI
Affinity DataKi:  37nM ΔG°:  -39.4kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rattus norvegicus (Rat))
Georgetown University; Duke University

US Patent
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)copy SMILEScopy InChI
Affinity DataKi:  40nM ΔG°:  -39.3kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Rattus norvegicus (Rat))
BioCryst Pharmaceuticals

LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  47nMMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Rattus norvegicus (Rat))
BioCryst Pharmaceuticals

LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)copy SMILEScopy InChI
Affinity DataKi:  47nM ΔG°:  -38.9kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rattus norvegicus (Rat))
Georgetown University; Duke University

US Patent
LigandPNGBDBM50382474(CHEMBL2024096 | US9303017, Sazetidine-A)copy SMILEScopy InChI
Affinity DataKi:  52nM ΔG°:  -38.6kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM397480(US9993465, (R)-16 | US9993465, (S)-16)copy SMILEScopy InChI
Affinity DataKi:  73nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MQ8US Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM50428083(CHEMBL2323568 | US9303017, (S)-16, YL-1-169)copy SMILEScopy InChI
Affinity DataKi:  73nM ΔG°:  -37.9kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-4(Rattus norvegicus (Rat))
BioCryst Pharmaceuticals

LigandPNGBDBM50166908(5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca...)copy SMILEScopy InChI
Affinity DataKi:  94nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MQ8US Patent
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-4(Rattus norvegicus (Rat))
BioCryst Pharmaceuticals

LigandPNGBDBM221048(US9284322, varenicline | US9303017, Varenicline)copy SMILEScopy InChI
Affinity DataKi:  94nM ΔG°:  -37.3kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
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