Compile Data Set for Download or QSAR
Found 709 with Last Name = 'phillips' and Initial = 'ma'
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50434228(CHEMBL2385512)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM15339(6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-qui...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant DHODHMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM15339(6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-qui...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM14711(Asinex compound no. 6 | N-(3,5-Dichlorophenyl)-2-m...)copy SMILEScopy InChI
Affinity DataIC50: 16nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50434229(CHEMBL2385511)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4JS3PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
University of Washington

Curated by ChEMBL
LigandPNGBDBM50018011(Aubagio | CHEBI:68540 | HMR-1726 | TERIFLUNOMIDE)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of C-terminal His6-tagged rat DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
University of Washington

Curated by ChEMBL
LigandPNGBDBM50018011(Aubagio | CHEBI:68540 | HMR-1726 | TERIFLUNOMIDE)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of rat DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid production using dihydroorot...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50434230(CHEMBL2385510)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4JS3PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50095120(CHEMBL3589752)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of His-tagged human DHODH assessed as reduction of DCIP by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20V8FJTPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM50345406(CHEMBL1784574 | N-(4-tert-Butyl-3-fluorophenyl)-5-...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of His6-tagged recombinant Plasmodium falciparum dihydroorotate dehydrogenase expressed in Escherichia coli using L-dihydroorotate as subs...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN16HSPubMed
TargetOrnithine decarboxylase(Rattus norvegicus)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50005719((APA)O-(3-Amino-propyl)-hydroxylamine | 3-AMINOOXY...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of rat liver ornithine decarboxylaseMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50434231(CHEMBL2385515)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4JS3PubMed
TargetOrnithine decarboxylase(Rattus norvegicus)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50005727(1-Amino-3-aminooxy-propan-2-ol | CHEMBL26857)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:Inhibition of rat liver ornithine decarboxylaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KS6RQMPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Washington at Seattle

LigandPNGBDBM24400(5-methyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a...)copy SMILEScopy InChI
Affinity DataIC50: 47nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Washington at Seattle

LigandPNGBDBM24400(5-methyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a...)copy SMILEScopy InChI
Affinity DataIC50: 47nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
University of Washington

Curated by ChEMBL
LigandPNGBDBM50018006(CHEMBL3289672 | US9238653, Table 5, Compound 49)copy SMILEScopy InChI
Affinity DataIC50: 49nMAssay Description:Inhibition of rat DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid production using dihydroorot...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM15345(Asinex compound no. 1 | N-(2,4-dichlorophenyl)naph...)copy SMILEScopy InChI
Affinity DataIC50: 50nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM14710(ChemBridge compound no. 2 | N-(4-Bromo-2-methylphe...)copy SMILEScopy InChI
Affinity DataIC50: 50nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [R265A](Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM14710(ChemBridge compound no. 2 | N-(4-Bromo-2-methylphe...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Washington at Seattle

LigandPNGBDBM24413(JMC521864 Compund DSM2 | N-(anthracen-2-yl)-5-meth...)copy SMILEScopy InChI
Affinity DataIC50: 56nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Washington at Seattle

LigandPNGBDBM24413(JMC521864 Compund DSM2 | N-(anthracen-2-yl)-5-meth...)copy SMILEScopy InChI
Affinity DataIC50: 56nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM15349(Asinex compound no. 4 | N-(3-bromophenyl)-2-methyl...)copy SMILEScopy InChI
Affinity DataIC50: 60nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM50345441(5-Methyl-N-(5,6,7,8-tetrahydronaphthalen-2yl)-[1,2...)copy SMILEScopy InChI
Affinity DataIC50: 64nMAssay Description:Inhibition of His6-tagged recombinant Plasmodium falciparum dihydroorotate dehydrogenase expressed in Escherichia coli using L-dihydroorotate as subs...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN16HSPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Washington at Seattle

LigandPNGBDBM28843(N-[3-fluoro-4-(trifluoromethyl)phenyl]-5-methyl-[1...)copy SMILEScopy InChI
Affinity DataIC50: 77nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN653CPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM50345420(CHEMBL1784561 | N-(4-tert-Butylphenyl)-5-methyl-[1...)copy SMILEScopy InChI
Affinity DataIC50: 78nMAssay Description:Inhibition of His6-tagged recombinant Plasmodium falciparum dihydroorotate dehydrogenase expressed in Escherichia coli using L-dihydroorotate as subs...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN16HSPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM15355(2-methyl-3-nitro-N-[3-(trifluoromethyl)phenyl]benz...)copy SMILEScopy InChI
Affinity DataIC50: 80nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM15353(2-methyl-N-(naphthalen-1-yl)-3-nitrobenzamide | Ch...)copy SMILEScopy InChI
Affinity DataIC50: 80nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [R265A](Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM15345(Asinex compound no. 1 | N-(2,4-dichlorophenyl)naph...)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM15354(Asinex compound no. 9 | N-(3,4-dichlorophenyl)-2-m...)copy SMILEScopy InChI
Affinity DataIC50: 80nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL
LigandPNGBDBM50018006(CHEMBL3289672 | US9238653, Table 5, Compound 49)copy SMILEScopy InChI
Affinity DataIC50: 88nMAssay Description:Inhibition of mouse DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid production using dihydroor...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM50345385(CHEMBL1784580 | N-(Benzo[b]thiophen-5-yl)-5-methyl...)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Inhibition of His6-tagged recombinant Plasmodium falciparum dihydroorotate dehydrogenase expressed in Escherichia coli using L-dihydroorotate as subs...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN16HSPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50434232(CHEMBL2385514)copy SMILEScopy InChI
Affinity DataIC50: 95nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4JS3PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM15350(ChemBridge compound no. 5 | N-(3-chloro-4-fluoroph...)copy SMILEScopy InChI
Affinity DataIC50: 100nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL
LigandPNGBDBM50018011(Aubagio | CHEBI:68540 | HMR-1726 | TERIFLUNOMIDE)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of C-terminal His6-tagged mouse DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
University of Washington

Curated by ChEMBL
LigandPNGBDBM50018008(CHEMBL3289671 | US9238653, Table 5, Compound 43)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of rat DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid production using dihydroorot...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1FZ6PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM50345414(CHEMBL1784567 | N-(4-Pentafluorosulfenylphenyl)-5-...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of His6-tagged recombinant Plasmodium falciparum dihydroorotate dehydrogenase expressed in Escherichia coli using L-dihydroorotate as subs...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN16HSPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL
LigandPNGBDBM50018011(Aubagio | CHEBI:68540 | HMR-1726 | TERIFLUNOMIDE)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Inhibition of mouse DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid production using dihydroor...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Washington at Seattle

LigandPNGBDBM24403(5,6-dimethyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1...)copy SMILEScopy InChI
Affinity DataIC50: 160nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HNFPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM50345436(5-Chloro-N-(4-trifluoromethyl)phenyl)-[1,2,4]triaz...)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Inhibition of His6-tagged recombinant Plasmodium falciparum dihydroorotate dehydrogenase expressed in Escherichia coli using L-dihydroorotate as subs...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN16HSPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL
LigandPNGBDBM50018008(CHEMBL3289671 | US9238653, Table 5, Compound 43)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Inhibition of mouse DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid production using dihydroor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1FZ6PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Washington at Seattle

LigandPNGBDBM24402(5-ethyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a]...)copy SMILEScopy InChI
Affinity DataIC50: 190nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HNFPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM50345442(CHEMBL1784577 | N-(3,5-Difluoro-4-(trifluoromethyl...)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Inhibition of His6-tagged recombinant Plasmodium falciparum dihydroorotate dehydrogenase expressed in Escherichia coli using L-dihydroorotate as subs...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN16HSPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50018011(Aubagio | CHEBI:68540 | HMR-1726 | TERIFLUNOMIDE)copy SMILEScopy InChI
Affinity DataIC50: 210nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid pro...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Washington at Seattle

LigandPNGBDBM24401(N-(naphthalen-2-yl)-5-(trifluoromethyl)-[1,2,4]tri...)copy SMILEScopy InChI
Affinity DataIC50: 210nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HNFPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM50345443(CHEMBL586157 | N-(2,3-Dihydro1H-inden-5-yl)-5-meth...)copy SMILEScopy InChI
Affinity DataIC50: 220nMAssay Description:Inhibition of His6-tagged recombinant Plasmodium falciparum dihydroorotate dehydrogenase expressed in Escherichia coli using L-dihydroorotate as subs...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN16HSPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM50345421(CHEMBL600255 | N-(4-isopropylphenyl)-5-methyl-[1,2...)copy SMILEScopy InChI
Affinity DataIC50: 220nMAssay Description:Inhibition of His6-tagged recombinant Plasmodium falciparum dihydroorotate dehydrogenase expressed in Escherichia coli using L-dihydroorotate as subs...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN16HSPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM15357(3-(2-methoxyphenyl)-1-naphthalen-1-ylurea | ChemBr...)copy SMILEScopy InChI
Affinity DataIC50: 230nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [100-517](Plasmodium berghei)
University of Washington at Seattle

LigandPNGBDBM24400(5-methyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a...)copy SMILEScopy InChI
Affinity DataIC50: 230nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN653CPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [R265A](Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM15357(3-(2-methoxyphenyl)-1-naphthalen-1-ylurea | ChemBr...)copy SMILEScopy InChI
Affinity DataIC50: 240nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))TBA
LigandPNGBDBM50567995(CHEMBL4851471 | US11903936, Compound 20)copy SMILES
Affinity DataIC50: 250nMAssay Description:Inhibition of CYP2D6 (unknown origin) by UPLC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ8CD4PubMed
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