Compile Data Set for Download or QSAR
Found 156 with Last Name = 'van zandt' and Initial = 'mc'
TargetArginase(Schistosoma mansoni (flatworms))
University of Pennsylvania

LigandPNGBDBM130378(2(S)-amino-6-boronohexanoic acid (ABH))copy SMILEScopy InChI
Affinity DataKi:  1.80E+3nMpH: 8.5Assay Description:Briefly, 0.5-50 mM L-arginine (pH 8.5) was added to a solution of 50 mM 4-(2-hydroxyethyl)piperazine-1-propanesulfonic acid (EPPS) (pH 8.5) and 100 &...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RR1WZQPubMed
TargetArginase(Schistosoma mansoni (flatworms))
University of Pennsylvania

LigandPNGBDBM130379(N-hydroxy-L-arginine (NOHA))copy SMILEScopy InChI
Affinity DataKi:  3.70E+3nMpH: 8.5Assay Description:Briefly, 0.5-50 mM L-arginine (pH 8.5) was added to a solution of 50 mM 4-(2-hydroxyethyl)piperazine-1-propanesulfonic acid (EPPS) (pH 8.5) and 100 &...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RR1WZQPubMed
TargetArginase-1(Homo sapiens (Human))
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509011(CHEMBL4538713)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92FM9PubMed
TargetArginase-1(Homo sapiens (Human))
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509016(CHEMBL4450972)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92FM9PubMed
TargetArginase-1(Homo sapiens (Human))
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509014(CHEMBL4557975)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92FM9PubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16485(2-{6-methoxy-3-[(4,5,7-trifluoro-1,3-benzothiazol-...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16469(2-{3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methy...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16491(2-{7-methyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16482(2-{6-fluoro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16488(2-{7-fluoro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetArginase-1(Homo sapiens (Human))
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509010(CHEMBL4518246)copy SMILEScopy InChI
Affinity DataIC50: 7.70nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92FM9PubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16470(2-{2-methyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)copy SMILEScopy InChI
Affinity DataIC50: 8nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16481(2-[5-(morpholin-4-yl)-3-[(4,5,7-trifluoro-1,3-benz...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16496(2-{3-[(4-bromo-2-fluorophenyl)methyl]-7-chloro-2,4...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16493(2-{3-[2-(4,5,7-trifluoro-1,3-benzothiazol-2-yl)eth...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16483(2-{6-chloro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16477(2-{5-methoxy-3-[(4,5,7-trifluoro-1,3-benzothiazol-...)copy SMILEScopy InChI
Affinity DataIC50: 8nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16476(2-{5-methyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)copy SMILEScopy InChI
Affinity DataIC50: 8nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16489(2-{7-chloro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16464(2-{3-[(5-fluoro-1,3-benzothiazol-2-yl)methyl]-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 9nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetArginase-1(Homo sapiens (Human))
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509018(CHEMBL4461464)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92FM9PubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16484(2-{6-methyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetArginase-1(Homo sapiens (Human))
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509012(CHEMBL4572850)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92FM9PubMed
TargetArginase-1(Homo sapiens (Human))
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509015(CHEMBL4594157)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92FM9PubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16473(2-{5-chloro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)copy SMILEScopy InChI
Affinity DataIC50: 10nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16474(2-{5-fluoro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)copy SMILEScopy InChI
Affinity DataIC50: 11nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16472(2-{4-chloro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)copy SMILEScopy InChI
Affinity DataIC50: 11nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetArginase-1(Homo sapiens (Human))
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509017(CHEMBL4578964)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92FM9PubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16478(2-[5-(benzyloxy)-3-[(4,5,7-trifluoro-1,3-benzothia...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16475(2-{5-bromo-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-...)copy SMILEScopy InChI
Affinity DataIC50: 13nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16490(2-{7-bromo-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16487(2-[6-(morpholin-4-yl)-3-[(4,5,7-trifluoro-1,3-benz...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetArginase-1(Homo sapiens (Human))
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509009(CHEMBL4530103)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92FM9PubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16494(3-{3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methy...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetArginase-1(Homo sapiens (Human))
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509019(CHEMBL4459462)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92FM9PubMed
TargetArginase-1(Homo sapiens (Human))
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509003(CHEMBL4556601)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92FM9PubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16486(2-{6-phenyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetArginase-1(Homo sapiens (Human))
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509013(CHEMBL4434802)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92FM9PubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16479(2-{5-phenoxy-3-[(4,5,7-trifluoro-1,3-benzothiazol-...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16463(2-{3-[(4-fluoro-1,3-benzothiazol-2-yl)methyl]-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 34nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16461(2-(6-bromo-3-{[5-(trifluoromethyl)-1,3-benzothiazo...)copy SMILEScopy InChI
Affinity DataIC50: 52nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16480(2-{5-phenyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)copy SMILEScopy InChI
Affinity DataIC50: 53nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16466(2-{3-[(7-fluoro-1,3-benzothiazol-2-yl)methyl]-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 55nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetArginase-1(Homo sapiens (Human))
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50427899(CHEMBL2326090)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BC40WPPubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL
LigandPNGBDBM50427899(CHEMBL2326090)copy SMILEScopy InChI
Affinity DataIC50: 67nMAssay Description:Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BC40WPPubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16458(2-(3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]m...)copy SMILEScopy InChI
Affinity DataIC50: 99nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16459(2-(5-methyl-3-{[5-(trifluoromethyl)-1,3-benzothiaz...)copy SMILEScopy InChI
Affinity DataIC50: 100nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetArginase-1(Homo sapiens (Human))
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM290395((3R,4S)-3-amino-4-(3-boronopropyl)-1-((1-methyl-1H...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92FM9PubMed
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