TargetProtein kinase C theta type(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Affinity DataIC50: 0.25nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
TargetProtein kinase C theta type(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Affinity DataIC50: 0.460nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
TargetProtein kinase C theta type(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Affinity DataIC50: 4.30nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 5.80nMAssay Description:Inhibition of GST-tagged human CDK2/CCNA2 (04 to 103 residues) pre-incubated for 5 mins before addition of histone H1 substrate and [gamma-33P]ATP an...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal GST-tagged GSK-3beta (unknown origin) expressed in baculovirus preincubated for 5 mins using GSK3 substrate peptide measured...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal GST-tagged human TrkA expressed in baculovirus preincubated for 5 mins measured after 10 mins in presence of ATP by AlphaScr...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of CLK (unknown origin)More data for this Ligand-Target Pair
TargetProtein kinase C alpha type(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCalpha (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
TargetProtein kinase C delta type(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCdelta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
TargetProtein kinase C beta type(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCbeta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measur...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 13/Cyclin-K(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK13 (1 to 1512 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of GST-tagged human CDK2/CCNA2 (04 to 103 residues) pre-incubated for 5 mins before addition of histone H1 substrate and [gamma-33P]ATP an...More data for this Ligand-Target Pair
In DepthDetails
TargetProtein kinase C theta type(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of PKCtheta in human Jurkat cells after overnight incubation by luminescence analysisMore data for this Ligand-Target Pair
In DepthDetails
TargetProtein kinase C theta type(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Mus musculus)
Takeda California, Inc.
Curated by ChEMBL
Takeda California, Inc.
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of mouse ATX using TG-mTMP as substrate after 2 hrs by fluorometric analysisMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of GST-tagged human CDK9/CycT1 (04 to 110 residues) assessed as reduction in ATP-dependent ULight-4E-BP1 (Thr37/Thr46) substrate peptide p...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of GST-tagged human CDK8/CycC (04 to 109 residues) using kinase tracer 236 probe incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetProtein kinase C theta type(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of PKCtheta in human Jurkat cells after overnight incubation by luminescence analysisMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Mus musculus)
Takeda California, Inc.
Curated by ChEMBL
Takeda California, Inc.
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of mouse ATX using TG-mTMP as substrate after 2 hrs by fluorometric analysisMore data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of GST-tagged human CDK2/CCNA2 (04 to 103 residues) pre-incubated for 5 mins before addition of histone H1 substrate and [gamma-33P]ATP an...More data for this Ligand-Target Pair
In DepthDetails
In DepthDetails
In DepthDetails
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of GST-tagged human CDK2/CCNA2 (04 to 103 residues) pre-incubated for 5 mins before addition of histone H1 substrate and [gamma-33P]ATP an...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of GST-tagged human CDK2/CCNA2 (04 to 103 residues) pre-incubated for 5 mins before addition of histone H1 substrate and [gamma-33P]ATP an...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
TargetProtein kinase C theta type(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
TargetCyclin-K/Cyclin-dependent kinase 12(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 52nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 53nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 13/Cyclin-K(Homo sapiens (Human))
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK13 (1 to 1512 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 59nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
TargetProtein kinase C theta type(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
Affinity DataIC50: 62nMAssay Description:Inhibition of human N-terminal His6-tagged TEV protease site linked DHPS expressed in Escherichia coli BL21 (DE3) assessed as reduction in radiolabel...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 63nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 63nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
TargetU5 small nuclear ribonucleoprotein 200 kDa helicase(Homo sapiens (Human))
Takeda California Inc.
Curated by ChEMBL
Takeda California Inc.
Curated by ChEMBL
Affinity DataIC50: 79nMAssay Description:Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...More data for this Ligand-Target Pair
Affinity DataIC50: 92nMAssay Description:Inhibition of human N-terminal His6-tagged TEV protease site linked DHPS expressed in Escherichia coli BL21 (DE3) assessed as reduction in radiolabel...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
Affinity DataIC50: 99nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of N-terminal FLAG-tagged FAK cytoplasmic domain (unknown origin) expressed in baculovirus preincubated for 5 mins measured after 20 mins ...More data for this Ligand-Target Pair
TargetProtein kinase C theta type(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human c-Met preincubated for 5 mins measured after 10 mins in presence of ATP by AlphaScreen assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of full length N-terminal His-tagged recombinant human SRC preincubated for 5 mins measured after 10 mins in presence of ATP by AlphaScree...More data for this Ligand-Target Pair
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