Compile Data Set for Download or QSAR
Found 2405 with Last Name = 'reutershan' and Initial = 'mh'
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))TBA
LigandPNGBDBM50433561(CHEMBL2381408)copy SMILEScopy InChI
Affinity DataKi:  0.880nMAssay Description:Binding affinity to recombinant human His6-tagged HDM2 (1 to 118 residues) assessed as reduction in PMDM6-F binding incubated for 15 to 30 mins by fl...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM301997(US9598405, 1.5 | US9598405, 1.6)copy SMILEScopy InChI
Affinity DataIC50: 0.0710nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8V7TUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM302002(US9598405, 2.1)copy SMILEScopy InChI
Affinity DataIC50: 0.0720nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8V7TUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM302016(US9598405, 3.1)copy SMILEScopy InChI
Affinity DataIC50: 0.0730nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8V7TUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM302034(BDBM302035 | US9598405, 4.1)copy SMILEScopy InChI
Affinity DataIC50: 0.0860nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8V7TUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM302018(US9598405, 3.3 | US9598405, 3.7)copy SMILEScopy InChI
Affinity DataIC50: 0.0920nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8V7TUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM302028(US9598405, 3.13)copy SMILEScopy InChI
Affinity DataIC50: 0.0970nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8V7TUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM301993(BDBM301994 | US9598405, 1.1)copy SMILEScopy InChI
Affinity DataIC50: 0.103nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8V7TUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM302029(US9598405, 3.14)copy SMILEScopy InChI
Affinity DataIC50: 0.104nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8V7TUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM302032(US9598405, 3.17)copy SMILEScopy InChI
Affinity DataIC50: 0.113nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8V7TUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM302000(US9598405, 1.8)copy SMILEScopy InChI
Affinity DataIC50: 0.119nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8V7TUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM302030(US9598405, 3.15)copy SMILEScopy InChI
Affinity DataIC50: 0.127nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8V7TUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM302013(US9598405, 2.12)copy SMILEScopy InChI
Affinity DataIC50: 0.152nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8V7TUS Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM227653(3-{6-(5-chloropyridin-3- yl)-8-[1-(2,6- difluoroph...)copy SMILES
Affinity DataIC50: 0.156nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X1FUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM302017(US9598405, 3.2 | US9598405, 3.6)copy SMILEScopy InChI
Affinity DataIC50: 0.158nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8V7TUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM302033(US9598405, 3.18)copy SMILEScopy InChI
Affinity DataIC50: 0.160nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8V7TUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM302042(US9598405, 5.1)copy SMILEScopy InChI
Affinity DataIC50: 0.161nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8V7TUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM301996(US9598405, 1.4)copy SMILEScopy InChI
Affinity DataIC50: 0.164nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8V7TUS Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM227651(6-(5-chloropyridin-3-yl)- 8-[1-fluoro-1-(2- fluoro...)copy SMILEScopy InChI
Affinity DataIC50: 0.176nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X1FUS Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM223046(6-{[(1r)-1- cyclobutylethyl]amino}- 7-[(trans-4- m...)copy SMILEScopy InChI
Affinity DataIC50: 0.202nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X1FUS Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM224125(3-{6-[3-chloro-5- (hydroxymethyl)phen- yl]-7-[(tra...)copy SMILES
Affinity DataIC50: 0.205nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X1FUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM302026(US9598405, 3.11)copy SMILEScopy InChI
Affinity DataIC50: 0.208nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8V7TUS Patent
LigandPNGBDBM515298(US11098059, Example 2 | US11098059, Example 6)copy SMILES
Affinity DataIC50: 0.210nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5X5XUS Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM224261(3-{8-[(2r)-4-acetyl- 2-phenylpiperazin-1- yl]-6-{[...)copy SMILES
Affinity DataIC50: 0.215nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X1FUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM302036(BDBM302037 | US9598405, 4.3)copy SMILEScopy InChI
Affinity DataIC50: 0.228nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8V7TUS Patent
LigandPNGBDBM515310(US11098059, Example 14)copy SMILES
Affinity DataIC50: 0.240nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5X5XUS Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM227665(5-{6-(5-chloropyridin-3- yl)-8-[1-(2,6- difluoroph...)copy SMILES
Affinity DataIC50: 0.289nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X1FUS Patent
LigandPNGBDBM515307(6'-(1-cyclopropyl-1H-1,2,4- triazol-5-yl)-2'-{(2R)...)copy SMILES
Affinity DataIC50: 0.290nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5X5XUS Patent
LigandPNGBDBM515299(US11098059, Example 3 | US11098059, Example 7)copy SMILES
Affinity DataIC50: 0.310nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5X5XUS Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM227683(3-{6-(5-chloropyridin-3- yl)-8-[1-fluoro-1-(3- flu...)copy SMILES
Affinity DataIC50: 0.315nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X1FUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM302006(US9598405, 2.5)copy SMILEScopy InChI
Affinity DataIC50: 0.316nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8V7TUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM302014(US9598405, 2.13)copy SMILEScopy InChI
Affinity DataIC50: 0.333nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8V7TUS Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM223705(3-(6-{[(1r)-1- cyclobutylethyl]amino}- 8- (hexahyd...)copy SMILES
Affinity DataIC50: 0.344nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X1FUS Patent
LigandPNGBDBM515323(6-(hexahydro-3,6- epiminofuro[3,2-b]furan- 7-carbo...)copy SMILES
Affinity DataIC50: 0.350nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5X5XUS Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM227669(5-{6-(5-chloropyridin-3- yl)-8-[1-fluoro-1-(3- flu...)copy SMILES
Affinity DataIC50: 0.359nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X1FUS Patent
LigandPNGBDBM515309(US11098059, Example 13)copy SMILES
Affinity DataIC50: 0.360nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5X5XUS Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM223402(6-{[(1r)-1- cyclobutylethyl]amino}- 7-[(trans-4- m...)copy SMILEScopy InChI
Affinity DataIC50: 0.381nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X1FUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM302039(US9598405, 4.6)copy SMILEScopy InChI
Affinity DataIC50: 0.392nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8V7TUS Patent
LigandPNGBDBM515306(6-(1-cyclopropyl-1H-1,2,4- triazol-5-yl)-4-ethyl-2...)copy SMILES
Affinity DataIC50: 0.400nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5X5XUS Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM226428(3-{6-(5-chloropyridin-3- yl)-8-[1-fluoro-1-(2- flu...)copy SMILES
Affinity DataIC50: 0.424nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X1FUS Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM227696(2-{1-[6-(5-chloropyridin- 3-yl)-7-[(trans-4- methy...)copy SMILES
Affinity DataIC50: 0.435nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X1FUS Patent
LigandPNGBDBM515321(2-((R)-2-hydroxy-2-((S)- 1,2,3,4- tetrahydroisoqui...)copy SMILES
Affinity DataIC50: 0.440nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5X5XUS Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM227678(3-{6-(5-chloropyridin-3- yl)-8-[1-(2,6- difluoroph...)copy SMILES
Affinity DataIC50: 0.452nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X1FUS Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM226426(5-{6-(5-chloropyridin-3- yl)-8-[1-fluoro-1-(2- flu...)copy SMILES
Affinity DataIC50: 0.453nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X1FUS Patent
LigandPNGBDBM515305(6-(1-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-{(2R)-2-...)copy SMILES
Affinity DataIC50: 0.470nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5X5XUS Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM224176(5-{6-(5- chloropyridin-3-yl)- 8-[(3r)-3-(2- fluoro...)copy SMILES
Affinity DataIC50: 0.494nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X1FUS Patent
LigandPNGBDBM515319(US11098059, Example 23)copy SMILES
Affinity DataIC50: 0.5nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5X5XUS Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM224216(3-{6-(5- chloropyridin-3-yl)- 7-[(trans-4- methylc...)copy SMILES
Affinity DataIC50: 0.504nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X1FUS Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM223681(3-(6-{[(1r)-1- cyclobutylethyl]amino}- 8-[2-(1-met...)copy SMILES
Affinity DataIC50: 0.507nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X1FUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Merck Sharp & Dohme Corp.

US Patent
LigandPNGBDBM302034(BDBM302035 | US9598405, 4.1)copy SMILEScopy InChI
Affinity DataIC50: 0.508nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8V7TUS Patent
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