Compile Data Set for Download or QSAR
Found 127 with Last Name = 'hickey' and Initial = 'mj'
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343354(2-Amino-4-[2,4-dichloro-6-(2-pyrazol-1-ylethoxy)ph...)copy SMILEScopy InChI
Affinity DataKi:  6nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343355(2-Amino-4-[2,4-dichloro-6-(2-pyrazol-1-ylethoxy)ph...)copy SMILEScopy InChI
Affinity DataKi:  7nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343380(2-Amino-4-[2,4-dichloro-6-(2-pyrazol-1-ylethoxy)ph...)copy SMILEScopy InChI
Affinity DataKi:  7nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343372(Amino-4-(2,4-dichloro-6-phenethyloxyphenyl)-5,7-di...)copy SMILEScopy InChI
Affinity DataKi:  7nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343370(2-Amino-4-[2,4-dichloro-6-(4,4,4-trifluorobutoxy)p...)copy SMILEScopy InChI
Affinity DataKi:  7nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343386(2-Amino-4-[2,4-dichloro-6-(2-pyrazol-1-ylethoxy)ph...)copy SMILEScopy InChI
Affinity DataKi:  9nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343385(2-Amino-4-[2,4-dichloro-6-(2-pyrazol-1-ylethoxy)ph...)copy SMILEScopy InChI
Affinity DataKi:  9nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343356(2-Amino-4-[2,4-dichloro-6-(2-pyrazol-1-ylethoxy)ph...)copy SMILEScopy InChI
Affinity DataKi:  11nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343384(4-(2-(2-(1H-pyrazol-1-yl)ethoxy)-4,6-dichloropheny...)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343383(2-Amino-4-[2,4-dichloro-6-(2-pyrazol-1-ylethoxy)ph...)copy SMILEScopy InChI
Affinity DataKi:  13nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343378(2-Amino-4-{2,4-dichloro-6-[2-(3,3-difluoro-azetidi...)copy SMILEScopy InChI
Affinity DataKi:  16nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343369(2-Amino-4-[2,4-dichloro-6-(4,4,4-trifluorobutoxy)p...)copy SMILEScopy InChI
Affinity DataKi:  18nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343382(2-Amino-4-[2,4-dichloro-6-(2-pyrazol-1-ylethoxy)ph...)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343368(2-Amino-4-[2,4-dichloro-6-(4,4,4-trifluorobutoxy)p...)copy SMILEScopy InChI
Affinity DataKi:  21nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343366(2-Amino-4-[2,4-dichloro-6-(4,4,4-trifluorobutoxy)p...)copy SMILEScopy InChI
Affinity DataKi:  26nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343373(2-Amino-4-[2,4-dichloro-6-(2-pyridin-2-ylethoxy)ph...)copy SMILEScopy InChI
Affinity DataKi:  27nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343381(2-Amino-4-[2,4-dichloro-6-(2-pyrazol-1-ylethoxy)ph...)copy SMILEScopy InChI
Affinity DataKi:  35nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343367(2-Amino-4-[2,4-dichloro-6-(4,4,4-trifluorobutoxy)p...)copy SMILEScopy InChI
Affinity DataKi:  38nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343374(2-amino-N-cyclobutyl-4-(2,4-dichloro-6-(3-cyanopro...)copy SMILEScopy InChI
Affinity DataKi:  40nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343365(4-[2,4-Dichloro-6-(4,4,4-trifluoro-butoxy)-phenyl]...)copy SMILEScopy InChI
Affinity DataKi:  50nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343371(2-amino-N-cyclobutyl-4-(2,4-dichloro-6-propoxyphen...)copy SMILEScopy InChI
Affinity DataKi:  110nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343377(2-Amino-4-[2,4-dichloro-6-(2-methoxyethoxy)phenyl]...)copy SMILEScopy InChI
Affinity DataKi:  120nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343364(4-[2-Chloro-6-(4,4,4-trifluoro-butoxy)-phenyl]-6-m...)copy SMILEScopy InChI
Affinity DataKi:  130nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343376(2-Amino-4-[2,4-dichloro-6-(3-hydroxypropoxy)phenyl...)copy SMILEScopy InChI
Affinity DataKi:  190nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343379(2-Amino-4-[2,4-dichloro-6-(2-ethylamino-ethoxy)-ph...)copy SMILEScopy InChI
Affinity DataKi:  250nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343375(2-Amino-4-[2,4-dichloro-6-(3-cyano-3,3-dimethylpro...)copy SMILEScopy InChI
Affinity DataKi:  300nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343362(4-(2-chloro-6-methoxyphenyl)-6-methylpyrimidin-2-a...)copy SMILEScopy InChI
Affinity DataKi:  700nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343360(4-Chloro-6-(2-methoxyphenyl)-pyrimidin-2-ylamine |...)copy SMILEScopy InChI
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343363(2-(2-amino-6-methylpyrimidin-4-yl)-3-chlorophenol ...)copy SMILEScopy InChI
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343361(4-(2-methoxyphenyl)-6-methylpyrimidin-2-amine | CH...)copy SMILEScopy InChI
Affinity DataKi:  8.30E+3nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343365(4-[2,4-Dichloro-6-(4,4,4-trifluoro-butoxy)-phenyl]...)copy SMILEScopy InChI
Affinity DataKi:  1.16E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320M5PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50028854(CHEMBL3342693)copy SMILEScopy InChI
Affinity DataKi:  4.13E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50028854(CHEMBL3342693)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human microsomal PGES1 expressed in 293E cells by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50142254(CHEMBL3759288)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human microsomal PGES1 expressed in 293E cells by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50142253(CHEMBL3758924)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human microsomal PGES1 expressed in 293E cells by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50142252(CHEMBL3758953)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human microsomal PGES1 expressed in 293E cells by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50227631(2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)iso...)copy SMILEScopy InChI
Affinity DataIC50: 5.30nMAssay Description:Inhibition of human microsomal PGES1 expressed in 293E cells by LC/MS/MS analysisMore data for this Ligand-Target Pair
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50142255(CHEMBL3758222)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human microsomal PGES1 expressed in 293E cells by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50028854(CHEMBL3342693)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of mPGES1 in rhIL-1beta-stimulated human A549 cells assessed as PGE2 level treated for 18 hrs after 30 mins pre-incubation with rhIL-1beta...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50028854(CHEMBL3342693)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of mPGES1 in LPS-induced human whole blood assessed as suppression of PGE2 response after 20 to 24 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50142252(CHEMBL3758953)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of mPGES1 in rhIL-1beta-stimulated human A549 cells assessed as PGE2 level treated for 18 hrs after 30 mins pre-incubation with rhIL-1beta...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50142251(CHEMBL3758663)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of human microsomal PGES1 expressed in 293E cells by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50142253(CHEMBL3758924)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Inhibition of mPGES1 in LPS-induced human whole blood assessed as suppression of PGE2 response after 20 to 24 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50142253(CHEMBL3758924)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Inhibition of mPGES1 in rhIL-1beta-stimulated human A549 cells assessed as PGE2 level treated for 18 hrs after 30 mins pre-incubation with rhIL-1beta...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50142254(CHEMBL3759288)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:Inhibition of mPGES1 in rhIL-1beta-stimulated human A549 cells assessed as PGE2 level treated for 18 hrs after 30 mins pre-incubation with rhIL-1beta...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50142257(CHEMBL3758879)copy SMILEScopy InChI
Affinity DataIC50: 74nMAssay Description:Inhibition of human microsomal PGES1 expressed in 293E cells by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50227631(2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)iso...)copy SMILEScopy InChI
Affinity DataIC50: 76nMAssay Description:Inhibition of mPGES1 in rhIL-1beta-stimulated human A549 cells assessed as PGE2 level treated for 18 hrs after 30 mins pre-incubation with rhIL-1beta...More data for this Ligand-Target Pair
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50142254(CHEMBL3759288)copy SMILEScopy InChI
Affinity DataIC50: 91nMAssay Description:Inhibition of mPGES1 in LPS-induced human whole blood assessed as suppression of PGE2 response after 20 to 24 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50142255(CHEMBL3758222)copy SMILEScopy InChI
Affinity DataIC50: 98nMAssay Description:Inhibition of mPGES1 in rhIL-1beta-stimulated human A549 cells assessed as PGE2 level treated for 18 hrs after 30 mins pre-incubation with rhIL-1beta...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CQRPubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50005781(ALVESPIMYCIN | CHEBI:65324)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of Hsp90 in human H1299 assessed as degradation of Hsp90 client protein AktMore data for this Ligand-Target Pair
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