Compile Data Set for Download or QSAR
Found 145 with Last Name = 'mansour' and Initial = 'mn'
TargetStromelysin-1(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50073839(CHEMBL283066 | [4-(1,3-Dioxo-1,3-dihydro-isoindol-...)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:Inhibition of recombinant matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JD4VZ4PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50073823(CHEMBL24871 | {4-[((S)-1-Acetyl-pyrrolidine-2-carb...)copy SMILEScopy InChI
Affinity DataKi:  6.10nMAssay Description:Inhibition of recombinant matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JD4VZ4PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50073839(CHEMBL283066 | [4-(1,3-Dioxo-1,3-dihydro-isoindol-...)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Inhibition of recombinant matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JD4VZ4PubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50073823(CHEMBL24871 | {4-[((S)-1-Acetyl-pyrrolidine-2-carb...)copy SMILEScopy InChI
Affinity DataKi:  62nMAssay Description:Inhibition of recombinant matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JD4VZ4PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM15413(4-(4-fluorophenyl)-5-[1-(propan-2-yl)-1H-1,2,3-ben...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMpH: 7.2 T: 2°CAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5RMPPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50118009((6,7-Diethoxy-quinazolin-4-yl)-(3-thiazol-2-yl-phe...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PN94Z0PubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31149(3-hydroxyquinolin-2(1H)-one, 3)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31173(naphthyridinone analog., 27)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50117952((6,7-Diethoxy-quinazolin-4-yl)-(3-furan-2-yl-pheny...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PN94Z0PubMed
TargetD-amino-acid oxidase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM31173(naphthyridinone analog., 27)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50095256((6,7-Dimethoxy-quinazolin-4-yl)-(3-ethynyl-4-fluor...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PN94Z0PubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31156(3-hydroxyquinolin-2(1H)-one, 10)copy SMILEScopy InChI
Affinity DataIC50: 4nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)copy SMILEScopy InChI
Affinity DataIC50: 4nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31172(3-hydroxyquinolin-2(1H)-one, 26)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM15414(4-(4-fluorophenyl)-5-[3-(propan-2-yl)-[1,2,4]triaz...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 7.2 T: 2°CAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31161(3-hydroxyquinolin-2(1H)-one, 15)copy SMILEScopy InChI
Affinity DataIC50: 8nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31152(3-hydroxyquinolin-2(1H)-one, 6)copy SMILEScopy InChI
Affinity DataIC50: 8nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31164(naphthyridinone analog.,18)copy SMILEScopy InChI
Affinity DataIC50: 8nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31147(4H-furo[3,2-b]pyrrole-5-carboxylic acid | 5-carbox...)copy SMILEScopy InChI
Affinity DataIC50: 9nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31151(3-hydroxyquinolin-2(1H)-one, 5)copy SMILEScopy InChI
Affinity DataIC50: 9nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31150(3-hydroxyquinolin-2(1H)-one, 4)copy SMILEScopy InChI
Affinity DataIC50: 10nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50117986((6,7-Diethoxy-quinazolin-4-yl)-[3-(1H-pyrazol-3-yl...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PN94Z0PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50117983((6,7-Diethoxy-quinazolin-4-yl)-(3-thiazol-5-yl-phe...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PN94Z0PubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50073830((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JD4VZ4PubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31160(3-hydroxyquinolin-2(1H)-one, 14)copy SMILEScopy InChI
Affinity DataIC50: 16nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50117970((6,7-Diethoxy-quinazolin-4-yl)-(3-thiazol-4-yl-phe...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PN94Z0PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM15412(5-[4-(4-Fluoro-phenyl)-oxazol-5-yl]-1-isopropyl-3-...)copy SMILEScopy InChI
Affinity DataIC50: 30nMpH: 7.2 T: 2°CAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5RMPPubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50073822((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JD4VZ4PubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31165(naphthyridinone analog.,19)copy SMILEScopy InChI
Affinity DataIC50: 32nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31153(3-hydroxyquinolin-2(1H)-one, 7)copy SMILEScopy InChI
Affinity DataIC50: 33nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31157(3-hydroxyquinolin-2(1H)-one, 11)copy SMILEScopy InChI
Affinity DataIC50: 38nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
TargetD-amino-acid oxidase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM31156(3-hydroxyquinolin-2(1H)-one, 10)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50073824((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)copy SMILEScopy InChI
Affinity DataIC50: 45nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JD4VZ4PubMed
TargetD-amino-acid oxidase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM31172(3-hydroxyquinolin-2(1H)-one, 26)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50073833((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JD4VZ4PubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31154(3-hydroxyquinolin-2(1H)-one, 8)copy SMILEScopy InChI
Affinity DataIC50: 100nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50073831((4-Benzyl-benzyl)-[3-cyclobutyl-2-((R)-2,2-dimethy...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JD4VZ4PubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31167(naphthyridinone analog.,21)copy SMILEScopy InChI
Affinity DataIC50: 128nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31155(3-hydroxyquinolin-2(1H)-one, 9)copy SMILEScopy InChI
Affinity DataIC50: 155nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
TargetD-amino-acid oxidase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM31149(3-hydroxyquinolin-2(1H)-one, 3)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50073833((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JD4VZ4PubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50073831((4-Benzyl-benzyl)-[3-cyclobutyl-2-((R)-2,2-dimethy...)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JD4VZ4PubMed
TargetD-amino-acid oxidase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM31152(3-hydroxyquinolin-2(1H)-one, 6)copy SMILEScopy InChI
Affinity DataIC50: 196nMAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31158(3-hydroxyquinolin-2(1H)-one, 12)copy SMILEScopy InChI
Affinity DataIC50: 197nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50073837((4-Benzyl-benzyl)-[3-cyclopropyl-2-((R)-2,2-dimeth...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JD4VZ4PubMed
TargetD-amino-acid oxidase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM31164(naphthyridinone analog.,18)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
TargetD-amino-acid oxidase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)copy SMILEScopy InChI
Affinity DataIC50: 215nMAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50073846((4-Benzyl-benzyl)-{2-[(R)-2-(4-hydroxy-phenyl)-1-m...)copy SMILEScopy InChI
Affinity DataIC50: 270nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JD4VZ4PubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50073828(Benzyl-[2-((R)-2,2-dimethyl-1-methylcarbamoyl-prop...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JD4VZ4PubMed
TargetD-amino-acid oxidase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM31151(3-hydroxyquinolin-2(1H)-one, 5)copy SMILEScopy InChI
Affinity DataIC50: 308nMAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ35HMPubMed
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