Compile Data Set for Download or QSAR
Found 202 with Last Name = 'van schravendijk' and Initial = 'mr'
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50132351(({4-[6-(2,6-Dichloro-phenyl)-8-(3-dimethylamino-pr...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21J995TPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50314074(2,6,9-Trisubstitute purine, 6 (AP23464) | 3-(2-(2-...)copy SMILEScopy InChI
Affinity DataIC50: 0.450nMpH: 7.4 T: 2°CAssay Description:Inhibition of human Src kinase activity by ARIAD compounds were measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FR...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M61HRQPubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
ARIAD Gene Therapeutics

Curated by ChEMBL
LigandPNGBDBM50086083(1-[2-(3,4,5-Trimethoxy-phenyl)-pent-4-enoyl]-piper...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Binding affinity for Mutant F36V-FK506 binding protein by competitive assay based on fluorescence polarization.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2057F45PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
ARIAD Gene Therapeutics

Curated by ChEMBL
LigandPNGBDBM50086090(1-[2-(3,4,5-Trimethoxy-phenyl)-butyryl]-piperidine...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Binding affinity for Mutant F36V-FK506 binding protein by competitive assay based on fluorescence polarization.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2057F45PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50132348(({4-[6-(2,6-Dichloro-phenyl)-8-methyl-7-oxo-7,8-di...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21J995TPubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
ARIAD Gene Therapeutics

Curated by ChEMBL
LigandPNGBDBM50086094(1-[2-(3,4,5-Trimethoxy-phenyl)-pentanoyl]-piperidi...)copy SMILEScopy InChI
Affinity DataIC50: 3.80nMAssay Description:Binding affinity for Mutant F36V-FK506 binding protein by competitive assay based on fluorescence polarization.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2057F45PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of Cyclin-dependent kinase 2 (CDK2)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25B01V7PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
ARIAD Gene Therapeutics

Curated by ChEMBL
LigandPNGBDBM50086077(1-[3-Cyclopropyl-2-(3,4,5-trimethoxy-phenyl)-propi...)copy SMILEScopy InChI
Affinity DataIC50: 4.40nMAssay Description:Binding affinity for Mutant F36V-FK506 binding protein by competitive assay based on fluorescence polarization.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2057F45PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
ARIAD Gene Therapeutics

Curated by ChEMBL
LigandPNGBDBM50086092(1-[3-Methyl-2-(3,4,5-trimethoxy-phenyl)-butyryl]-p...)copy SMILEScopy InChI
Affinity DataIC50: 5.80nMAssay Description:Binding affinity for Mutant F36V-FK506 binding protein by competitive assay based on fluorescence polarization.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2057F45PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
ARIAD Gene Therapeutics

Curated by ChEMBL
LigandPNGBDBM50086078(1-(2-Cyclohexyl-2-phenyl-acetyl)-piperidine-2-carb...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Binding affinity for Mutant F36V-FK506 binding protein by competitive assay based on fluorescence polarization.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2057F45PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM3071(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 38 | 2-ani...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21J995TPubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
ARIAD Gene Therapeutics

Curated by ChEMBL
LigandPNGBDBM50086087(1-(3-Methyl-2-phenyl-butyryl)-piperidine-2-carboxy...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Binding affinity for Mutant F36V-FK506 binding protein by competitive assay based on fluorescence polarization.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2057F45PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
ARIAD Gene Therapeutics

Curated by ChEMBL
LigandPNGBDBM50086082(1-[2-(3,4,5-Trimethoxy-phenyl)-pent-4-enoyl]-piper...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Binding affinity for Mutant F36V-FK506 binding protein by competitive assay based on fluorescence polarization.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2057F45PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM81618(2,6,9-Trisubstitute purine, 3)copy SMILEScopy InChI
Affinity DataIC50: 25nMpH: 7.4 T: 2°CAssay Description:Inhibition of human Src kinase activity by ARIAD compounds were measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FR...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M61HRQPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM81619(2,6,9-Trisubstitute purine, 4)copy SMILEScopy InChI
Affinity DataIC50: 26nMpH: 7.4 T: 2°CAssay Description:Inhibition of human Src kinase activity by ARIAD compounds were measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FR...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M61HRQPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM81620(2,6,9-Trisubstitute purine, 5)copy SMILEScopy InChI
Affinity DataIC50: 34nMpH: 7.4 T: 2°CAssay Description:Inhibition of human Src kinase activity by ARIAD compounds were measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FR...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M61HRQPubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
ARIAD Gene Therapeutics

Curated by ChEMBL
LigandPNGBDBM50086085(1-(2-Phenyl-butyryl)-piperidine-2-carboxylic acid ...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Binding affinity for Mutant F36V-FK506 binding protein by competitive assay based on fluorescence polarization.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2057F45PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50451556(CHEMBL3084838)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:Inhibition of Src-mediated dentine resorption in rabbit-osteoclast assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25B01V7PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
ARIAD Gene Therapeutics

Curated by ChEMBL
LigandPNGBDBM50086075(1-[2-(3,4,5-Trimethoxy-phenyl)-pentanoyl]-piperidi...)copy SMILEScopy InChI
Affinity DataIC50: 43nMAssay Description:Binding affinity for Mutant F36V-FK506 binding protein by competitive assay based on fluorescence polarization.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2057F45PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
ARIAD Gene Therapeutics

Curated by ChEMBL
LigandPNGBDBM50086086(1-[3-Methyl-2-(3,4,5-trimethoxy-phenyl)-butyryl]-p...)copy SMILEScopy InChI
Affinity DataIC50: 65nMAssay Description:Binding affinity for Mutant F36V-FK506 binding protein by competitive assay based on fluorescence polarization.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2057F45PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
ARIAD Gene Therapeutics

Curated by ChEMBL
LigandPNGBDBM50086079(1-(2-Cyclohexyl-2-phenyl-acetyl)-piperidine-2-carb...)copy SMILEScopy InChI
Affinity DataIC50: 66nMAssay Description:Binding affinity for Mutant F36V-FK506 binding protein by competitive assay based on fluorescence polarization.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2057F45PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM81623(2,6,9-Trisubstitute purine, 9 (AP23451))copy SMILEScopy InChI
Affinity DataIC50: 67nMpH: 7.4 T: 2°CAssay Description:Inhibition of human Src kinase activity by ARIAD compounds were measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FR...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M61HRQPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Mus musculus (Mouse))
ARIAD Pharmaceuticals, Inc.

LigandPNGBDBM50318870(((4-(2-(cis-4-aminocyclohexyl)-9-ethyl-9H-purin-6-...)copy SMILEScopy InChI
Affinity DataIC50: 68nMAssay Description:2,6,9-Trisubstituted purines were evaluated for their src kinase inhibitory activities using an ELISA assay.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QTQPubMedMMDB
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 70nMpH: 7.4 T: 2°CAssay Description:Inhibition of human Src kinase activity by ARIAD compounds were measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FR...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M61HRQPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Mus musculus (Mouse))
ARIAD Pharmaceuticals, Inc.

LigandPNGBDBM81725(2,6,9-Trisubstituted Purine, AP23517)copy SMILEScopy InChI
Affinity DataIC50: 73nMAssay Description:2,6,9-Trisubstituted purines were evaluated for their src kinase inhibitory activities using an ELISA assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QTQPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50132352(({3-[6-(2,6-Dichloro-phenyl)-8-methyl-7-oxo-7,8-di...)copy SMILEScopy InChI
Affinity DataIC50: 77nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21J995TPubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
ARIAD Gene Therapeutics

Curated by ChEMBL
LigandPNGBDBM50086080(1-(2-Phenyl-propionyl)-piperidine-2-carboxylic aci...)copy SMILEScopy InChI
Affinity DataIC50: 94nMAssay Description:Binding affinity for Mutant F36V-FK506 binding protein by competitive assay based on fluorescence polarization.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2057F45PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Mus musculus (Mouse))
ARIAD Pharmaceuticals, Inc.

LigandPNGBDBM81723(2,6,9-Trisubstituted Purine, 10)copy SMILEScopy InChI
Affinity DataIC50: 101nMAssay Description:2,6,9-Trisubstituted purines were evaluated for their src kinase inhibitory activities using an ELISA assay.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QTQPubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
ARIAD Gene Therapeutics

Curated by ChEMBL
LigandPNGBDBM50086089(1-[3-Cyclopropyl-2-(3,4,5-trimethoxy-phenyl)-propi...)copy SMILEScopy InChI
Affinity DataIC50: 126nMAssay Description:Binding affinity for Mutant F36V-FK506 binding protein by competitive assay based on fluorescence polarization.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2057F45PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
ARIAD Gene Therapeutics

Curated by ChEMBL
LigandPNGBDBM50086084(1-(2-Phenyl-butyryl)-piperidine-2-carboxylic acid ...)copy SMILEScopy InChI
Affinity DataIC50: 133nMAssay Description:Binding affinity for Mutant F36V-FK506 binding protein by competitive assay based on fluorescence polarization.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2057F45PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50451553(CHEMBL3084839)copy SMILEScopy InChI
Affinity DataIC50: 141nMAssay Description:Inhibition of Src-mediated dentine resorption in rabbit-osteoclast assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25B01V7PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
ARIAD Gene Therapeutics

Curated by ChEMBL
LigandPNGBDBM50086081(1-(3-Methyl-2-phenyl-butyryl)-piperidine-2-carboxy...)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Binding affinity for Mutant F36V-FK506 binding protein by competitive assay based on fluorescence polarization.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2057F45PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
ARIAD Gene Therapeutics

Curated by ChEMBL
LigandPNGBDBM50086093(1-[2-(3,4,5-Trimethoxy-phenyl)-butyryl]-piperidine...)copy SMILEScopy InChI
Affinity DataIC50: 187nMAssay Description:Binding affinity for Mutant F36V-FK506 binding protein by competitive assay based on fluorescence polarization.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2057F45PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50132353(CHEMBL102801 | {4-[6-(2,6-Dichloro-phenyl)-8-methy...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21J995TPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Mus musculus (Mouse))
ARIAD Pharmaceuticals, Inc.

LigandPNGBDBM81722(2,6,9-Trisubstituted Purine, 9)copy SMILEScopy InChI
Affinity DataIC50: 205nMAssay Description:2,6,9-Trisubstituted purines were evaluated for their src kinase inhibitory activities using an ELISA assay.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QTQPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM81622(2,6,9-Trisubstitute purine, 8)copy SMILEScopy InChI
Affinity DataIC50: 239nMpH: 7.4 T: 2°CAssay Description:Inhibition of human Src kinase activity by ARIAD compounds were measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FR...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M61HRQPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 240nMpH: 7.4 T: 2°CAssay Description:Inhibition of human Src kinase activity by ARIAD compounds were measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FR...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M61HRQPubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
ARIAD Gene Therapeutics

Curated by ChEMBL
LigandPNGBDBM50086076(1-Diphenylacetyl-piperidine-2-carboxylic acid 1-(3...)copy SMILEScopy InChI
Affinity DataIC50: 273nMAssay Description:Binding affinity for Mutant F36V-FK506 binding protein by competitive assay based on fluorescence polarization.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2057F45PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Mus musculus (Mouse))
ARIAD Pharmaceuticals, Inc.

LigandPNGBDBM50318870(((4-(2-(cis-4-aminocyclohexyl)-9-ethyl-9H-purin-6-...)copy SMILEScopy InChI
Affinity DataIC50: 273nMAssay Description:2,6,9-Trisubstituted purines were evaluated for their src kinase inhibitory activities using an ELISA assay.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QTQPubMedMMDB
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
ARIAD Gene Therapeutics

Curated by ChEMBL
LigandPNGBDBM50086091(1-(2-Phenyl-propionyl)-piperidine-2-carboxylic aci...)copy SMILEScopy InChI
Affinity DataIC50: 590nMAssay Description:Binding affinity for Mutant F36V-FK506 binding protein by competitive assay based on fluorescence polarization.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2057F45PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Mus musculus (Mouse))
ARIAD Pharmaceuticals, Inc.

LigandPNGBDBM81718(2,6,9-Trisubstituted Purine, 4)copy SMILEScopy InChI
Affinity DataIC50: 665nMAssay Description:2,6,9-Trisubstituted purines were evaluated for their src kinase inhibitory activities using an ELISA assay.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QTQPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50132350(({4-[6-(2,6-Dichloro-phenyl)-8-methyl-7-oxo-7,8-di...)copy SMILEScopy InChI
Affinity DataIC50: 750nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21J995TPubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

LigandPNGBDBM5106(1,2,4-Oxadiazole Analogue 15c | 4-[(2S)-2-{[(1S)-2...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SBPPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Mus musculus (Mouse))
ARIAD Pharmaceuticals, Inc.

LigandPNGBDBM81720(2,6,9-Trisubstituted Purine, 6)copy SMILEScopy InChI
Affinity DataIC50: 1.01E+3nMAssay Description:2,6,9-Trisubstituted purines were evaluated for their src kinase inhibitory activities using an ELISA assay.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QTQPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50132349(CHEMBL320374 | {5-[6-(2,6-Dichloro-phenyl)-8-methy...)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21J995TPubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
ARIAD Gene Therapeutics

Curated by ChEMBL
LigandPNGBDBM50132547(1-Phenylacetyl-piperidine-2-carboxylic acid 1-(3-c...)copy SMILEScopy InChI
Affinity DataIC50: 1.53E+3nMAssay Description:Binding affinity for Mutant F36V-FK506 binding protein by competitive assay based on fluorescence polarization.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2057F45PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50113707(2,6,9-Trisubstitute purine, 2 | 2-(2-hydroxyethyla...)copy SMILEScopy InChI
Affinity DataIC50: 1.59E+3nMpH: 7.4 T: 2°CAssay Description:Inhibition of human Src kinase activity by ARIAD compounds were measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FR...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M61HRQPubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

LigandPNGBDBM5105(1,2,4-Oxadiazole Analogue 15b | 4-[(2S)-2-{[(1S)-1...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SBPPubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

LigandPNGBDBM5103(1,2,4-Oxadiazole Analogue 13c | 4-[(2S)-2-{[(1S)-1...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SBPPubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

LigandPNGBDBM5099(1,2,4-Oxadiazole Analogue 12c | 4-[(2S)-2-acetamid...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SBPPubMed
Displayed 1 to 50 (of 202 total ) | Next | Last >>
Jump to: