Compile Data Set for Download or QSAR
Found 178 with Last Name = 'devereux' and Initial = 'n'
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207120(3-isobutyl-8-((6-methoxyisoquinolin-4-yl)methyl)-1...)copy SMILEScopy InChI
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63NSCPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207130(8-((6,7-dimethoxy-1-methylisoquinolin-4-yl)methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63NSCPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207120(3-isobutyl-8-((6-methoxyisoquinolin-4-yl)methyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63NSCPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50117734(8-{5-[4-(2-Hydroxy-ethyl)-piperidine-1-sulfonyl]-2...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5FC2PubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117721(3-Isobutyl-1-methyl-8-[5-(piperazin-1-ylmethanesul...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5FC2PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50117719(4-[3-(3-Isobutyl-1-methyl-2,6-dioxo-2,3,6,7-tetrah...)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5FC2PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50117711(8-{5-[4-(2-Hydroxy-ethyl)-piperazine-1-sulfonyl]-2...)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5FC2PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50117724(3-(3-Isobutyl-1-methyl-2,6-dioxo-2,3,6,7-tetrahydr...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5FC2PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207121(CHEMBL245648 | N-(4-((8-((6,7-dimethoxyisoquinolin...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63NSCPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50117721(3-Isobutyl-1-methyl-8-[5-(piperazin-1-ylmethanesul...)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5FC2PubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117715(3-Isobutyl-1-methyl-8-[5-(4-methyl-piperazine-1-su...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5FC2PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207123(8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-3-(3-hyd...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63NSCPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207127(8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-1-methyl...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63NSCPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207132(8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-3-isobut...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63NSCPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50117707(8-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phe...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5FC2PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50117715(3-Isobutyl-1-methyl-8-[5-(4-methyl-piperazine-1-su...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5FC2PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50117715(3-Isobutyl-1-methyl-8-[5-(4-methyl-piperazine-1-su...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5FC2PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50117714(CHEMBL90164 | N-(2-Dimethylamino-ethyl)-N-ethyl-3-...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5FC2PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50117729(3-Isobutyl-8-{5-[4-(2-methoxy-ethyl)-piperazine-1-...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5FC2PubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117719(4-[3-(3-Isobutyl-1-methyl-2,6-dioxo-2,3,6,7-tetrah...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5FC2PubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117711(8-{5-[4-(2-Hydroxy-ethyl)-piperazine-1-sulfonyl]-2...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5FC2PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50022322(CHEMBL3298923)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human TRPA1 expressed in CHO-TREX cells assessed as inhibition of cinnamaldehyde-induced calcium flux incubated 10 mins prior ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833TKTPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50117732(3-Isobutyl-8-[2-isopropoxy-5-(4-methyl-piperazine-...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5FC2PubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117724(3-(3-Isobutyl-1-methyl-2,6-dioxo-2,3,6,7-tetrahydr...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5FC2PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50117722(CHEMBL89239 | N-(2-Dimethylamino-ethyl)-3-(3-isobu...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5FC2PubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117734(8-{5-[4-(2-Hydroxy-ethyl)-piperidine-1-sulfonyl]-2...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5FC2PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50022322(CHEMBL3298923)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Antagonist activity at human TRPA1 expressed in CHO-TREX cells assessed as inhibition of allyl isothiocyanate-induced calcium flux incubated 10 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833TKTPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50117736(8-{2-Ethoxy-5-[4-(2-hydroxy-ethyl)-piperazine-1-su...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5FC2PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50117701(8-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phe...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5FC2PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207131(3-(cyclopropylmethyl)-8-((6,7-dimethoxyisoquinolin...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63NSCPubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50022322(CHEMBL3298923)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Antagonist activity at human TRPA1 expressed in CHO-TREX cells assessed as inhibition of dibenzo[b,f ][1,4]oxazepine-4-carboxamide-induced calcium fl...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833TKTPubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50022321(CHEMBL3298922)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Antagonist activity at human TRPA1 expressed in CHO-TREX cells assessed as inhibition of cinnamaldehyde-induced calcium flux incubated 10 mins prior ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833TKTPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50117718(8-{5-[4-(2-Dimethylamino-ethyl)-piperazine-1-sulfo...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5FC2PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207137(8-(bicyclo[2.2.1]heptan-2-ylmethyl)-3-isobutyl-1-m...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63NSCPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50117708(8-[2-Ethoxy-5-(piperazin-1-ylmethanesulfonyl)-phen...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5FC2PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207125(8-((6,7-dimethoxy-3-methylisoquinolin-4-yl)methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63NSCPubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50022347(CHEMBL3299022)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Antagonist activity at human TRPA1 expressed in CHO-TREX cells assessed as inhibition of cinnamaldehyde-induced calcium flux incubated 10 mins prior ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833TKTPubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50022327(CHEMBL3299019)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Antagonist activity at human TRPA1 expressed in CHO-TREX cells assessed as inhibition of cinnamaldehyde-induced calcium flux incubated 10 mins prior ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833TKTPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207124(3-(cyclohexylmethyl)-8-((6,7-dimethoxyisoquinolin-...)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63NSCPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50117704(3-Cyclopropylmethyl-8-[2-ethoxy-5-(4-methyl-pipera...)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5FC2PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207126(8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-1-methyl...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63NSCPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207129(3-(3,4-dimethoxybenzyl)-8-((6,7-dimethoxyisoquinol...)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63NSCPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207134(3-isobutyl-8-(isoquinolin-4-ylmethyl)-1-methyl-1H-...)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63NSCPubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50022349(CHEMBL3299024)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:Antagonist activity at human TRPA1 expressed in CHO-TREX cells assessed as inhibition of cinnamaldehyde-induced calcium flux incubated 10 mins prior ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833TKTPubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117718(8-{5-[4-(2-Dimethylamino-ethyl)-piperazine-1-sulfo...)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5FC2PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50022328(CHEMBL3299020)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:Antagonist activity at human TRPA1 expressed in CHO-TREX cells assessed as inhibition of cinnamaldehyde-induced calcium flux incubated 10 mins prior ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833TKTPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207128(CHEMBL393913 | N-(4-((8-((6,7-dimethoxyisoquinolin...)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63NSCPubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50022317(CHEMBL3298251)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Antagonist activity at human TRPA1 expressed in CHO-TREX cells assessed as inhibition of cinnamaldehyde-induced calcium flux incubated 10 mins prior ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833TKTPubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50022323(CHEMBL3298924)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Antagonist activity at human TRPA1 expressed in CHO-TREX cells assessed as inhibition of cinnamaldehyde-induced calcium flux incubated 10 mins prior ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833TKTPubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50022389(CHEMBL3299025)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Antagonist activity at human TRPA1 expressed in CHO-TREX cells assessed as inhibition of cinnamaldehyde-induced calcium flux incubated 10 mins prior ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833TKTPubMed
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