Compile Data Set for Download or QSAR
Found 209 with Last Name = 'mount' and Initial = 'n'
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315675(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridin-2-yl)py...)copy SMILEScopy InChI
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315688(((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrol...)copy SMILEScopy InChI
Affinity DataKi:  5nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315674(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridin-3-yl)py...)copy SMILEScopy InChI
Affinity DataKi:  5.10nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315676(((3R,4S)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-p...)copy SMILEScopy InChI
Affinity DataKi: >5.30nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315686(((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrol...)copy SMILEScopy InChI
Affinity DataKi:  5.80nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315677(((3R,4S)-1-cyclobutyl-4-(2,4-difluorophenyl)pyrrol...)copy SMILEScopy InChI
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315680(((3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3...)copy SMILEScopy InChI
Affinity DataKi:  6.70nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50378743(CHEMBL1204061)copy SMILEScopy InChI
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315681(((3S,4R)-4-(2,4-difluorophenyl)-1-isopropylpyrroli...)copy SMILEScopy InChI
Affinity DataKi: >7.90nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315679(((3R,4S)-1-cyclopropyl-4-(2,4-difluorophenyl)pyrro...)copy SMILEScopy InChI
Affinity DataKi: >9.20nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315673(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridazin-3-yl)...)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315673(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridazin-3-yl)...)copy SMILEScopy InChI
Affinity DataKi: >10nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315691(((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrol...)copy SMILEScopy InChI
Affinity DataKi: >10nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315669(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyrimidin-4-yl)...)copy SMILEScopy InChI
Affinity DataKi: >10nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50378747(CHEMBL1204056)copy SMILEScopy InChI
Affinity DataKi: >10nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50378748(CHEMBL1204054)copy SMILEScopy InChI
Affinity DataKi: >10nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315692(CHEMBL1090488 | CHEMBL1204059)copy SMILEScopy InChI
Affinity DataKi: >10nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50029747((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)copy SMILEScopy InChI
Affinity DataKi:  21nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315692(CHEMBL1090488 | CHEMBL1204059)copy SMILEScopy InChI
Affinity DataKi:  27nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50378743(CHEMBL1204061)copy SMILEScopy InChI
Affinity DataKi:  36nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315676(((3R,4S)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-p...)copy SMILEScopy InChI
Affinity DataKi:  36nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315691(((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrol...)copy SMILEScopy InChI
Affinity DataKi:  48nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315674(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridin-3-yl)py...)copy SMILEScopy InChI
Affinity DataKi:  50nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315672(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridazin-3-yl)...)copy SMILEScopy InChI
Affinity DataKi:  52nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50378748(CHEMBL1204054)copy SMILEScopy InChI
Affinity DataKi:  56nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315677(((3R,4S)-1-cyclobutyl-4-(2,4-difluorophenyl)pyrrol...)copy SMILEScopy InChI
Affinity DataKi:  62nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315669(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyrimidin-4-yl)...)copy SMILEScopy InChI
Affinity DataKi:  64nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315675(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridin-2-yl)py...)copy SMILEScopy InChI
Affinity DataKi:  79nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315689(((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrol...)copy SMILEScopy InChI
Affinity DataKi:  97nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315688(((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrol...)copy SMILEScopy InChI
Affinity DataKi:  99nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50378746(CHEMBL1204065)copy SMILEScopy InChI
Affinity DataKi:  107nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315681(((3S,4R)-4-(2,4-difluorophenyl)-1-isopropylpyrroli...)copy SMILEScopy InChI
Affinity DataKi:  114nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50378747(CHEMBL1204056)copy SMILEScopy InChI
Affinity DataKi:  172nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315687(((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrol...)copy SMILEScopy InChI
Affinity DataKi:  176nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315678(((3R,4S)-1-butyl-4-(2,4-difluorophenyl)pyrrolidin-...)copy SMILEScopy InChI
Affinity DataKi:  233nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315680(((3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3...)copy SMILEScopy InChI
Affinity DataKi:  264nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315679(((3R,4S)-1-cyclopropyl-4-(2,4-difluorophenyl)pyrro...)copy SMILEScopy InChI
Affinity DataKi:  290nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315668(((3R,4S)-4-(2,4-difluorophenyl)-1-(pyrimidin-2-yl)...)copy SMILEScopy InChI
Affinity DataKi:  300nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315683(((3S,4R)-4-(2,4-difluorophenyl)-1-methylpyrrolidin...)copy SMILEScopy InChI
Affinity DataKi:  346nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315686(((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrol...)copy SMILEScopy InChI
Affinity DataKi:  350nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315682(((3S,4R)-4-(2,4-difluorophenyl)-1-ethylpyrrolidin-...)copy SMILEScopy InChI
Affinity DataKi:  355nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315685(((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrol...)copy SMILEScopy InChI
Affinity DataKi:  844nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14408(5-(2-butoxy-5-acetylpyridin-3-yl)-3-ethyl-2-[(1-me...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24TP4PubMed
LigandPNGBDBM14397(5-(5-acetyl-2-ethoxyphenyl)-1-methyl-3-propyl-1H,6...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMpH: 7.4 T: 2°CAssay Description:PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24TP4PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14392(3-ethyl-5-{5-[(4-ethylpiperazine-1-)sulfonyl]-2-(2...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMpH: 7.4 T: 2°CAssay Description:PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24TP4PubMed
LigandPNGBDBM14396(5-{2-ethoxy-5-[2-(morpholin-4-yl)acetyl]phenyl}-1-...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMpH: 7.4 T: 2°CAssay Description:PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24TP4PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14396(5-{2-ethoxy-5-[2-(morpholin-4-yl)acetyl]phenyl}-1-...)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMpH: 7.4 T: 2°CAssay Description:PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24TP4PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14407(5-(2-butoxy-5-acetylpyridin-3-yl)-3-ethyl-2-[2-(mo...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24TP4PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14398(5-(5-Acetyl-2-propoxy-3-pyridinyl)-3-ethyl-2-[(1-m...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMpH: 7.4 T: 2°CAssay Description:PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24TP4PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM14394(5-(2-butoxy-5-acetylpyridin-3-yl)-3-ethyl-2-(pyrid...)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMpH: 7.4 T: 2°CAssay Description:PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24TP4PubMed
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