Compile Data Set for Download or QSAR
Found 55 with Last Name = 'warren' and Initial = 'n'
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236228(CHEMBL4076035 | US11186582, Example 6)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236271(CHEMBL4103411 | US11186582, Example 225)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM107767(US11419874, PF-05180999 | US8598155, 2)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human full length PDE2a using cGMP as substrate by Scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236235(CHEMBL4066029 | US11186582, Example 4)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236243(CHEMBL4059930 | US11186582, Example 340)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236231(CHEMBL4087945 | US11186582, Example 349 | US114198...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Tested for the inhibitory activity against pepsin (Second pure eluting diastereomer )More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50166893(2-(3,4-Dimethoxy-benzyl)-7-[(R)-1-((R)-1-hydroxy-e...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of PDE2a (unknown origin) using cAMP as substrate after 30 mins by Scintillation proximity assayMore data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236226(CHEMBL4087412 | US11186582, Example 378 | US114198...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236242(CHEMBL4093237 | US11186582, Example 516)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236236(CHEMBL4095099 | US11186582, Example 5)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236241(CHEMBL4069050 | US11186582, Example 481)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236275(CHEMBL4081851 | US11186582, Example 235)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
TargetVoltage-dependent calcium channel alpha-2 delta subunit(Sus scrofa)
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50305900((+)-2-((1S,5S,6R)-6-(aminomethyl)bicyclo[3.2.0]hep...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7GCQPubMed
TargetVoltage-dependent calcium channel alpha-2 delta subunit(Sus scrofa)
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50305887(3,4-trans-2-(1-(aminomethyl)-3,4-dimethylcyclopent...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7GCQPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236233(CHEMBL4077469 | US11186582, Example 319)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetVoltage-dependent calcium channel alpha-2 delta subunit(Sus scrofa)
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50305894((+/-)-2-((6S)-6-(aminomethyl)bicyclo[3.2.0]heptan-...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7GCQPubMed
TargetVoltage-dependent calcium channel alpha-2 delta subunit(Sus scrofa)
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50305885(CHEMBL595172 | cis-2-((1R,5S)-3-(aminomethyl)bicyc...)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7GCQPubMed
TargetVoltage-dependent calcium channel alpha-2 delta subunit(Sus scrofa)
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50305899((-)-2-((1R,5R,6S)-6-(aminomethyl)bicyclo[3.2.0]hep...)copy SMILEScopy InChI
Affinity DataIC50: 46nMAssay Description:Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7GCQPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236239(CHEMBL4095653 | US11186582, Example 338)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Agonistic activity evaluated in CHO(Chinese hamster ovary) cells expressing mGluR2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236244(CHEMBL4065588 | US11186582, Example 268)copy SMILEScopy InChI
Affinity DataIC50: 52nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236276(CHEMBL4082820 | US11186582, Example 239)copy SMILEScopy InChI
Affinity DataIC50: 52nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236232(CHEMBL4062668 | US11186582, Example 309)copy SMILEScopy InChI
Affinity DataIC50: 62nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236273(CHEMBL4066638 | US11186582, Example 475)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetVoltage-dependent calcium channel alpha-2 delta subunit(Sus scrofa)
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50305886(2-((3R,4S)-1-(aminomethyl)-3,4-dimethylcyclopentyl...)copy SMILEScopy InChI
Affinity DataIC50: 107nMAssay Description:Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7GCQPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236229(CHEMBL4074644)copy SMILEScopy InChI
Affinity DataIC50: 140nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236227(CHEMBL1482245)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236272(CHEMBL4102860)copy SMILEScopy InChI
Affinity DataIC50: 210nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetVoltage-dependent calcium channel alpha-2 delta subunit(Sus scrofa)
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50305884(CHEMBL609569 | cis-2-((1R,5S)-3-(aminomethyl)bicyc...)copy SMILEScopy InChI
Affinity DataIC50: 332nMAssay Description:Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7GCQPubMed
TargetVoltage-dependent calcium channel alpha-2 delta subunit(Sus scrofa)
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50305897((+/-)-2-((7S)-7-(aminomethyl)bicyclo[4.2.0]octan-7...)copy SMILEScopy InChI
Affinity DataIC50: 600nMAssay Description:Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7GCQPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236274(CHEMBL4090625 | US11186582, Example 246)copy SMILEScopy InChI
Affinity DataIC50: 679nMAssay Description:Agonistic activity evaluated in CHO(Chinese hamster ovary) cells expressing mGluR2 receptorMore data for this Ligand-Target Pair
TargetVoltage-dependent calcium channel alpha-2 delta subunit(Sus scrofa)
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50305892(2-((2R,3aR)-2-(aminomethyl)octahydro-1H-inden-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 720nMAssay Description:Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7GCQPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236277(CHEMBL4100798 | US11186582, Example 244)copy SMILEScopy InChI
Affinity DataIC50: 987nMAssay Description:Agonistic activity evaluated in CHO(Chinese hamster ovary) cells expressing mGluR2 receptorMore data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236245(CHEMBL4064972)copy SMILEScopy InChI
Affinity DataIC50: 1.52E+3nMAssay Description:Tested for the inhibitory activity against HIV protease (Second pure eluting diastereomer )More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of PDE10A1 (unknown origin) using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetVoltage-dependent calcium channel alpha-2 delta subunit(Sus scrofa)
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50305890(2-((2R,3aR)-2-(aminomethyl)octahydropentalen-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 2.60E+3nMAssay Description:Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7GCQPubMed
TargetVoltage-dependent calcium channel alpha-2 delta subunit(Sus scrofa)
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50305895((+/-)-2-((6R)-6-(aminomethyl)bicyclo[3.2.0]heptan-...)copy SMILEScopy InChI
Affinity DataIC50: 2.80E+3nMAssay Description:Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7GCQPubMed
TargetVoltage-dependent calcium channel alpha-2 delta subunit(Sus scrofa)
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50305884(CHEMBL609569 | cis-2-((1R,5S)-3-(aminomethyl)bicyc...)copy SMILEScopy InChI
Affinity DataIC50: 2.90E+3nMAssay Description:Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7GCQPubMed
TargetVoltage-dependent calcium channel alpha-2 delta subunit(Sus scrofa)
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50305898((+/-)-2-((7R)-7-(aminomethyl)bicyclo[4.2.0]octan-7...)copy SMILEScopy InChI
Affinity DataIC50: 3.09E+3nMAssay Description:Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7GCQPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236234(CHEMBL4084910)copy SMILEScopy InChI
Affinity DataIC50: 5.36E+3nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetVoltage-dependent calcium channel alpha-2 delta subunit(Sus scrofa)
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50305896((+/-)-2-((1S)-1-(aminomethyl)octahydropentalen-1-y...)copy SMILEScopy InChI
Affinity DataIC50: 7.18E+3nMAssay Description:Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7GCQPubMed
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE1B (unknown origin) using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured after 30 min...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE5A1 (unknown origin) expressed in Baculovirus infected Sf9 insect cells using fluorescently labeled cGMP as substrate by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE6C (unknown origin) expressed in Baculovirus infected Sf9 insect cells using cGMP as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE7A (unknown origin) using fluorescently labeled cAMP as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human full length N-terminal GST-tagged PDE8A1 expressed in Baculovirus infected Sf9 insect cells using cAMP as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human full length N-terminal GST-tagged PDE11A4 expressed in Baculovirus infected Sf9 insect cells using cAMP as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human full length N-terminal GST-tagged PDE9A2 expressed in Baculovirus infected Sf9 insect cells using cGMP as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE4D3 (unknown origin) using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured after 30 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Agonistic activity evaluated in CHO(Chinese hamster ovary) cells expressing mGluR2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
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