Compile Data Set for Download or QSAR
Found 433 with Last Name = 'wishart' and Initial = 'n'
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM26399(14-fluoro-6-(piperazin-1-yl)-3,5-diazatricyclo[9.4...)copy SMILEScopy InChI
Affinity DataKi:  1.45nM ΔG°:  -50.4kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)copy SMILEScopy InChI
Affinity DataKi:  2.70nM ΔG°:  -48.9kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)copy SMILEScopy InChI
Affinity DataKi:  2.70nM ΔG°:  -48.9kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0CD9PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26397(2,4-diamino-5,6-disubstituted pyrimidine, 11 | 6-[...)copy SMILEScopy InChI
Affinity DataKi:  3.5nM ΔG°:  -48.3kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM26398(2,4-diamino-5,6-disubstituted pyrimidine, 12 | 6-[...)copy SMILEScopy InChI
Affinity DataKi:  3.60nM ΔG°:  -48.2kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM26396(2,4-diamino-5,6-disubstituted pyrimidine, 10 | 6-[...)copy SMILEScopy InChI
Affinity DataKi:  3.80nM ΔG°:  -48.1kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM26391(5-chloro-2-(piperazin-1-ylcarbonyl)-1H-indole | JN...)copy SMILEScopy InChI
Affinity DataKi:  4nM ΔG°:  -47.9kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM26400(2,4-diamino-5,6-disubstituted pyrimidine, 14 | 9-p...)copy SMILEScopy InChI
Affinity DataKi:  4.5nM ΔG°:  -47.6kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26396(2,4-diamino-5,6-disubstituted pyrimidine, 10 | 6-[...)copy SMILEScopy InChI
Affinity DataKi:  4.70nM ΔG°:  -47.5kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM26394(2,4-diamino-5,6-disubstituted pyrimidine, 8 | 4-(p...)copy SMILEScopy InChI
Affinity DataKi:  4.80nM ΔG°:  -47.5kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26390(4-(4-methylpiperazin-1-yl)-6-phenylpyrimidin-2-ami...)copy SMILEScopy InChI
Affinity DataKi:  5nM ΔG°:  -47.4kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM26397(2,4-diamino-5,6-disubstituted pyrimidine, 11 | 6-[...)copy SMILEScopy InChI
Affinity DataKi:  5.10nM ΔG°:  -47.3kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26399(14-fluoro-6-(piperazin-1-yl)-3,5-diazatricyclo[9.4...)copy SMILEScopy InChI
Affinity DataKi:  5.10nM ΔG°:  -47.3kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM26392(2,4-diamino-5,6-disubstituted pyrimidine, 6 | 6-(4...)copy SMILEScopy InChI
Affinity DataKi:  5.40nM ΔG°:  -47.2kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM26395(2,4-diamino-5,6-disubstituted pyrimidine, 9 | 6-(p...)copy SMILEScopy InChI
Affinity DataKi:  7.60nM ΔG°:  -46.3kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM26393(2,4-diamino-5,6-disubstituted pyrimidine, 7 | 6-(p...)copy SMILEScopy InChI
Affinity DataKi:  9.20nM ΔG°:  -45.9kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26398(2,4-diamino-5,6-disubstituted pyrimidine, 12 | 6-[...)copy SMILEScopy InChI
Affinity DataKi:  11nM ΔG°:  -45.4kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)copy SMILEScopy InChI
Affinity DataKi:  12nM ΔG°:  -45.2kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0CD9PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)copy SMILEScopy InChI
Affinity DataKi:  12nM ΔG°:  -45.2kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26394(2,4-diamino-5,6-disubstituted pyrimidine, 8 | 4-(p...)copy SMILEScopy InChI
Affinity DataKi:  13nM ΔG°:  -45.0kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM26390(4-(4-methylpiperazin-1-yl)-6-phenylpyrimidin-2-ami...)copy SMILEScopy InChI
Affinity DataKi:  14nM ΔG°:  -44.8kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26392(2,4-diamino-5,6-disubstituted pyrimidine, 6 | 6-(4...)copy SMILEScopy InChI
Affinity DataKi:  15.5nM ΔG°:  -44.6kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26391(5-chloro-2-(piperazin-1-ylcarbonyl)-1H-indole | JN...)copy SMILEScopy InChI
Affinity DataKi:  26nM ΔG°:  -43.3kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26229(2-Aminopyrimidine analog., 4 | 4-[2-amino-6-(4-met...)copy SMILEScopy InChI
Affinity DataKi:  35nM ΔG°:  -42.6kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26229(2-Aminopyrimidine analog., 4 | 4-[2-amino-6-(4-met...)copy SMILEScopy InChI
Affinity DataKi:  35nM ΔG°:  -42.6kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0CD9PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26400(2,4-diamino-5,6-disubstituted pyrimidine, 14 | 9-p...)copy SMILEScopy InChI
Affinity DataKi:  40nM ΔG°:  -42.2kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26230(2-Aminopyrimidine analog., 25 | 4-[2-amino-6-(pipe...)copy SMILEScopy InChI
Affinity DataKi:  42nM ΔG°:  -42.1kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26230(2-Aminopyrimidine analog., 25 | 4-[2-amino-6-(pipe...)copy SMILEScopy InChI
Affinity DataKi:  42nM ΔG°:  -42.1kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0CD9PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26393(2,4-diamino-5,6-disubstituted pyrimidine, 7 | 6-(p...)copy SMILEScopy InChI
Affinity DataKi:  51.9nM ΔG°:  -41.6kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26395(2,4-diamino-5,6-disubstituted pyrimidine, 9 | 6-(p...)copy SMILEScopy InChI
Affinity DataKi:  71nM ΔG°:  -40.8kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM26230(2-Aminopyrimidine analog., 25 | 4-[2-amino-6-(pipe...)copy SMILEScopy InChI
Affinity DataKi:  120nM ΔG°:  -39.5kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0CD9PubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM26229(2-Aminopyrimidine analog., 4 | 4-[2-amino-6-(4-met...)copy SMILEScopy InChI
Affinity DataKi:  245nM ΔG°:  -37.7kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0CD9PubMed
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM26229(2-Aminopyrimidine analog., 4 | 4-[2-amino-6-(4-met...)copy SMILEScopy InChI
Affinity DataKi:  275nM ΔG°:  -37.4kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0CD9PubMed
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM26229(2-Aminopyrimidine analog., 4 | 4-[2-amino-6-(4-met...)copy SMILEScopy InChI
Affinity DataKi:  275nM ΔG°:  -37.4kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM26230(2-Aminopyrimidine analog., 25 | 4-[2-amino-6-(pipe...)copy SMILEScopy InChI
Affinity DataKi:  339nM ΔG°:  -36.9kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0CD9PubMed
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM26230(2-Aminopyrimidine analog., 25 | 4-[2-amino-6-(pipe...)copy SMILEScopy InChI
Affinity DataKi:  339nM ΔG°:  -36.9kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0KM5PubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26230(2-Aminopyrimidine analog., 25 | 4-[2-amino-6-(pipe...)copy SMILEScopy InChI
Affinity DataKi:  933nM ΔG°:  -34.4kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0CD9PubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26229(2-Aminopyrimidine analog., 4 | 4-[2-amino-6-(4-met...)copy SMILEScopy InChI
Affinity DataKi:  1.29E+3nM ΔG°:  -33.6kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0CD9PubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)copy SMILEScopy InChI
Affinity DataKi:  1.32E+3nM ΔG°:  -33.6kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0CD9PubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)copy SMILEScopy InChI
Affinity DataKi:  2.24E+3nM ΔG°:  -32.2kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0CD9PubMed
TargetAromatase(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8826(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD3XSFPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8870(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD3XSFPubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426739(CHEMBL2322135)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN46CTPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8826(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD3XSFPubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426734(CHEMBL2322142)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN46CTPubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM15471(4-[(1-{[2-oxo-2-(thiophen-3-yl)ethyl]amino}cyclope...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q247483FPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8813(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)copy SMILEScopy InChI
Affinity DataIC50: 6nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD3XSFPubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8826(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD3XSFPubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8813(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)copy SMILEScopy InChI
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD3XSFPubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426732(CHEMBL2322134)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN46CTPubMed
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