Compile Data Set for Download or QSAR
Found 356 with Last Name = 'stamm' and Initial = 'nb'
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6811(18,23-dimethyl-3,13,18-triazahexacyclo[14.7.0.0^{2...)copy SMILEScopy InChI
Affinity DataIC50: 2nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6832(3-[3-(4-hydroxypiperidin-1-yl)propyl]-6-methoxy-18...)copy SMILEScopy InChI
Affinity DataIC50: 4nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6838(1-(2-{18-methyl-12,14-dioxo-3,13,18-triazahexacycl...)copy SMILEScopy InChI
Affinity DataIC50: 5nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6846(5-{2-[(4-hydroxycyclohexyl)amino]ethyl}-18-methyl-...)copy SMILEScopy InChI
Affinity DataIC50: 5nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6803(6-methoxy-18-methyl-3,13,18-triazahexacyclo[14.7.0...)copy SMILEScopy InChI
Affinity DataIC50: 6nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6815(6-fluoro-18,23-dimethyl-3,13,18-triazahexacyclo[14...)copy SMILEScopy InChI
Affinity DataIC50: 6nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6800(6-hydroxy-3,13,18-triazahexacyclo[14.7.0.0^{2,10}....)copy SMILEScopy InChI
Affinity DataIC50: 6nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6816(6-methoxy-18,23-dimethyl-3,13,18-triazahexacyclo[1...)copy SMILEScopy InChI
Affinity DataIC50: 7nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50032762((4aR,10bR)-8-Chloro-4-methyl-1,4,4a,5,6,10b-hexahy...)copy SMILEScopy InChI
Affinity DataIC50: 7.90nMAssay Description:In vitro inhibitory concentration required to inhibit Steroid 5-alpha-reductase type 1 in cultured Hs 68 human foreskin fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VD70NP
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6840(5-[2-(4-hydroxypiperidin-1-yl)ethyl]-18-methyl-3,1...)copy SMILEScopy InChI
Affinity DataIC50: 8nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6818(3-(3-hydroxypropyl)-3,13,18-triazahexacyclo[14.7.0...)copy SMILEScopy InChI
Affinity DataIC50: 8nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50368782(Bexlosteride | CHEMBL24955 | LY-191704)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T43TQXPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031890((10R,13S)-17-tert-Butylcarbamoyl-10,13-dimethyl-2,...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Compound was tested for inhibition of Type II 5-alpha-reductase in Human Prostate Homogenates (HPH)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T43TQXPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6796(18-methyl-6-(trifluoromethyl)-3,13,18-triazahexacy...)copy SMILEScopy InChI
Affinity DataIC50: 9nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6801(6-hydroxy-18-methyl-3,13,18-triazahexacyclo[14.7.0...)copy SMILEScopy InChI
Affinity DataIC50: 9nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6794(6-fluoro-18-methyl-3,13,18-triazahexacyclo[14.7.0....)copy SMILEScopy InChI
Affinity DataIC50: 9nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6804(6-ethoxy-18-methyl-3,13,18-triazahexacyclo[14.7.0....)copy SMILEScopy InChI
Affinity DataIC50: 10nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6843(5-{2-[(2-hydroxyethyl)amino]ethyl}-18-methyl-3,13,...)copy SMILEScopy InChI
Affinity DataIC50: 10nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6797(18-methyl-12,14-dioxo-3,13,18-triazahexacyclo[14.7...)copy SMILEScopy InChI
Affinity DataIC50: 10nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Compound was tested for inhibition of Type II 5-alpha-reductase in Human Prostate Homogenates (HPH).More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T43TQXPubMedDrugBank
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6794(6-fluoro-18-methyl-3,13,18-triazahexacyclo[14.7.0....)copy SMILEScopy InChI
Affinity DataIC50: 11nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6797(18-methyl-12,14-dioxo-3,13,18-triazahexacyclo[14.7...)copy SMILEScopy InChI
Affinity DataIC50: 11nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50044878(4,8-Dimethyl-1,4,4a,5,6,10b-hexahydro-2H-benzo[f]q...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T43TQXPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6842(18-methyl-5-[2-(piperidin-1-yl)ethyl]-3,13,18-tria...)copy SMILEScopy InChI
Affinity DataIC50: 11nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6818(3-(3-hydroxypropyl)-3,13,18-triazahexacyclo[14.7.0...)copy SMILEScopy InChI
Affinity DataIC50: 12nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6822(3-(3-hydroxypropyl)-6-methoxy-18-methyl-3,13,18-tr...)copy SMILEScopy InChI
Affinity DataIC50: 12nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6795(6-bromo-18-methyl-3,13,18-triazahexacyclo[14.7.0.0...)copy SMILEScopy InChI
Affinity DataIC50: 13nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6831(1-(3-{6-methoxy-18-methyl-12,14-dioxo-3,13,18-tria...)copy SMILEScopy InChI
Affinity DataIC50: 13nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6837(indolocarbazole deriv. 13a | methyl 1-(2-{18-methy...)copy SMILEScopy InChI
Affinity DataIC50: 13nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6833(6-methoxy-18-methyl-3-[3-(4-methylpiperazin-1-yl)p...)copy SMILEScopy InChI
Affinity DataIC50: 14nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6844(18-methyl-5-[2-(morpholin-4-yl)ethyl]-3,13,18-tria...)copy SMILEScopy InChI
Affinity DataIC50: 15nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6839(18-methyl-5-[2-(piperazin-1-yl)ethyl]-3,13,18-tria...)copy SMILEScopy InChI
Affinity DataIC50: 15nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6812(23-fluoro-18-methyl-3,13,18-triazahexacyclo[14.7.0...)copy SMILEScopy InChI
Affinity DataIC50: 16nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6800(6-hydroxy-3,13,18-triazahexacyclo[14.7.0.0^{2,10}....)copy SMILEScopy InChI
Affinity DataIC50: 17nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50044879((4aR,10bR)-8-Chloro-4,10b-dimethyl-1,4,4a,5,6,10b-...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T43TQXPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6798(6,18-dimethyl-3,13,18-triazahexacyclo[14.7.0.0^{2,...)copy SMILEScopy InChI
Affinity DataIC50: 18nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6813(23-methoxy-18-methyl-3,13,18-triazahexacyclo[14.7....)copy SMILEScopy InChI
Affinity DataIC50: 18nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6784(18-ethyl-3,13,18-triazahexacyclo[14.7.0.0^{2,10}.0...)copy SMILEScopy InChI
Affinity DataIC50: 19nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6851(5-{3-[(4-hydroxycyclohexyl)amino]propyl}-18-methyl...)copy SMILEScopy InChI
Affinity DataIC50: 19nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6848(5-{3-[(2-hydroxyethyl)amino]propyl}-18-methyl-3,13...)copy SMILEScopy InChI
Affinity DataIC50: 19nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6829(3-{2-[(2-hydroxyethyl)amino]ethyl}-6-methoxy-18-me...)copy SMILEScopy InChI
Affinity DataIC50: 21nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6835(6-methoxy-18-methyl-3-[3-(morpholin-4-yl)propyl]-3...)copy SMILEScopy InChI
Affinity DataIC50: 21nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6782(3,13,18-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^...)copy SMILEScopy InChI
Affinity DataIC50: 22nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6783(18-methyl-3,13,18-triazahexacyclo[14.7.0.0^{2,10}....)copy SMILEScopy InChI
Affinity DataIC50: 22nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6799(6-ethyl-18-methyl-3,13,18-triazahexacyclo[14.7.0.0...)copy SMILEScopy InChI
Affinity DataIC50: 22nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6827(3-{2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethyl}...)copy SMILEScopy InChI
Affinity DataIC50: 23nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6830(3-{2-[(4-hydroxycyclohexyl)amino]ethyl}-6-methoxy-...)copy SMILEScopy InChI
Affinity DataIC50: 23nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6841(5-{2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethyl}...)copy SMILEScopy InChI
Affinity DataIC50: 23nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6815(6-fluoro-18,23-dimethyl-3,13,18-triazahexacyclo[14...)copy SMILEScopy InChI
Affinity DataIC50: 23nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM6821(3-(2-hydroxyethyl)-6-methoxy-18-methyl-3,13,18-tri...)copy SMILEScopy InChI
Affinity DataIC50: 24nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0CPWPubMed
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