Compile Data Set for Download or QSAR
Found 367 with Last Name = 'broadbent' and Initial = 'nj'
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236228(CHEMBL4076035 | US11186582, Example 6)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236235(CHEMBL4066029 | US11186582, Example 4)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM107767(US11419874, PF-05180999 | US8598155, 2)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human full length PDE2a using cGMP as substrate by Scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236271(CHEMBL4103411 | US11186582, Example 225)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50166893(2-(3,4-Dimethoxy-benzyl)-7-[(R)-1-((R)-1-hydroxy-e...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of PDE2a (unknown origin) using cAMP as substrate after 30 mins by Scintillation proximity assayMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457704(CHEMBL4202565)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236243(CHEMBL4059930 | US11186582, Example 340)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236231(CHEMBL4087945 | US11186582, Example 349 | US114198...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Tested for the inhibitory activity against pepsin (Second pure eluting diastereomer )More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236242(CHEMBL4093237 | US11186582, Example 516)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457706(CHEMBL4216391)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457693(CHEMBL4218366)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236226(CHEMBL4087412 | US11186582, Example 378 | US114198...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457692(CHEMBL4211012)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457689(CHEMBL4206403)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457695(CHEMBL4217712)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457685(CHEMBL4210484)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457694(CHEMBL4211535)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457704(CHEMBL4202565)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human GlyT1c expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50543922(CHEMBL4640428)copy SMILEScopy InChI
Affinity DataIC50: 5.10nMAssay Description:Inhibition of GlyT1 in rat primary cortical neurons assessed as reduction in radiolabeled glycine uptake by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29027C0PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457703(CHEMBL4214250)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human GlyT1c expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50543917(CHEMBL4638182)copy SMILEScopy InChI
Affinity DataIC50: 6.70nMAssay Description:Inhibition of GlyT1 in rat primary cortical neurons assessed as reduction in radiolabeled glycine uptake by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29027C0PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236236(CHEMBL4095099 | US11186582, Example 5)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457695(CHEMBL4217712)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human GlyT1c expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457714(CHEMBL4214756)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457692(CHEMBL4211012)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human GlyT1c expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457691(CHEMBL4209849)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457688(CHEMBL4206639)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236241(CHEMBL4069050 | US11186582, Example 481)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457710(CHEMBL4210353)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457703(CHEMBL4214250)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50543918(CHEMBL4646639)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of GlyT1 in rat primary cortical neurons assessed as reduction in radiolabeled glycine uptake by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29027C0PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457702(CHEMBL4205995)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human GlyT1c expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457710(CHEMBL4210353)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human GlyT1c expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457706(CHEMBL4216391)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human GlyT1c expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457712(CHEMBL4206122)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457689(CHEMBL4206403)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human GlyT1c expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457687(CHEMBL4205471)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457702(CHEMBL4205995)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457693(CHEMBL4218366)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human GlyT1c expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50543920(CHEMBL4638896)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of GlyT1 in rat primary cortical neurons assessed as reduction in radiolabeled glycine uptake by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29027C0PubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50543921(CHEMBL4634285)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of GlyT1 in rat primary cortical neurons assessed as reduction in radiolabeled glycine uptake by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29027C0PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236275(CHEMBL4081851 | US11186582, Example 235)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50543922(CHEMBL4640428)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of human GlyT1 expressed in human HEK cells assessed as reduction in radiolabeled glycine uptake by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29027C0PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457685(CHEMBL4210484)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human GlyT1c expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457687(CHEMBL4205471)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human GlyT1c expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457713(CHEMBL4218894)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human GlyT1c expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457697(CHEMBL4215015)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human GlyT1c expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457713(CHEMBL4218894)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457698(CHEMBL4213968)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
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