Compile Data Set for Download or QSAR
Found 1049 with Last Name = 'martin' and Initial = 'nm'
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50348452(AZD-8055 | CHEMBL1801204 | US9102670, 1a)copy SMILEScopy InChI
Affinity DataIC50: 0.130nMAssay Description:Inhibition of recombinant FLAG-tagged mTOR (1362 to 2549) (unknown origin) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z97PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174595(US9102670, 14a)copy SMILEScopy InChI
Affinity DataIC50: 0.150nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174368(US9102670, 1cg)copy SMILEScopy InChI
Affinity DataIC50: 0.260nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174414(US9102670, 1du)copy SMILEScopy InChI
Affinity DataIC50: 0.390nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetPoly [ADP-ribose] polymerase 2(Mus musculus (Mouse))
KuDOS Pharmaceuticals Ltd.

LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:A FlashPlate scintillation proximity assay has been used to identify inhibitors of PARP-2. PARP-2 protein (recombinant) was bound down by a PARP-2 sp...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174467(US9102670, 4a)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174288(US9102670, 1c)copy SMILEScopy InChI
Affinity DataIC50: 1.84nMAssay Description:For mTOR enzyme activity assays, mTOR protein was isolated from HeLa cell cytoplasmic extract by immunoprecipitation, and activity determined essenti...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174287(US9102670, 1b)copy SMILEScopy InChI
Affinity DataIC50: 1.85nMAssay Description:For mTOR enzyme activity assays, mTOR protein was isolated from HeLa cell cytoplasmic extract by immunoprecipitation, and activity determined essenti...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174471(US9102670, 4e)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174472(US9102670, 4f)copy SMILEScopy InChI
Affinity DataIC50: 1.97nMAssay Description:For mTOR enzyme activity assays, mTOR protein was isolated from HeLa cell cytoplasmic extract by immunoprecipitation, and activity determined essenti...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd

LigandPNGBDBM27542(4-(3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QPXPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd

LigandPNGBDBM27570(4-[(4-fluoro-3-{[4-(oxolan-3-ylcarbonyl)piperazin-...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd

LigandPNGBDBM27567(4-({3-[(4-cyclopentanecarbonylpiperazin-1-yl)carbo...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd

LigandPNGBDBM27546(4-[(3-{[4-(pyrimidin-2-yl)piperazin-1-yl]carbonyl}...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd

LigandPNGBDBM27545(4-[(4-fluoro-3-{[4-(pyridin-2-yl)piperazin-1-yl]ca...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd

LigandPNGBDBM27542(4-(3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174293(US9102670, 1h)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174289(US9102670, 1d)copy SMILEScopy InChI
Affinity DataIC50: 2.45nMAssay Description:For mTOR enzyme activity assays, mTOR protein was isolated from HeLa cell cytoplasmic extract by immunoprecipitation, and activity determined essenti...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50310989((5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholin...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant FLAG-tagged mTOR (1362 to 2549) (unknown origin) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z97PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174413(US9102670, 1dt)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174686(US9102670, 18ca)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174472(US9102670, 4f)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174347(US9102670, 1bl)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50429701(AZD-2014 | CHEMBL2336325 | US9102670, 1ap)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMAssay Description:Inhibition of recombinant FLAG-tagged mTOR (1362 to 2549) (unknown origin) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z97PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd

LigandPNGBDBM27547(4-[(4-fluoro-3-{[4-(pyrimidin-2-yl)piperazin-1-yl]...)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd

LigandPNGBDBM27569(4-[(4-fluoro-3-{[4-(oxolan-2-ylcarbonyl)piperazin-...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174712(US9102670, 18db)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50429706(CHEMBL2336320 | US9102670, 14b)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174418(US9102670, 1dy)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd

LigandPNGBDBM50165496(1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)m...)copy SMILEScopy InChI
Affinity DataIC50: 3.80nMAssay Description:Inhibitory concentration against human poly (ADP-ribose) polymerase 1 (PARP-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3M0BPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174514(US9102670, 4av)copy SMILEScopy InChI
Affinity DataIC50: 3.80nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd

LigandPNGBDBM27563(4-[(3-{[4-(cyclopropylmethyl)piperazin-1-yl]carbon...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd

LigandPNGBDBM50165488(1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)m...)copy SMILEScopy InChI
Affinity DataIC50: 4.10nMAssay Description:Inhibitory concentration against human poly (ADP-ribose) polymerase 1 (PARP-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3M0BPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174602(US9102670, 15a)copy SMILEScopy InChI
Affinity DataIC50: 4.30nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174290(US9102670, 1e)copy SMILEScopy InChI
Affinity DataIC50: 4.40nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174360(US9102670, 1by)copy SMILEScopy InChI
Affinity DataIC50: 4.60nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174703(US9102670, 18cs)copy SMILEScopy InChI
Affinity DataIC50: 4.70nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174439(US9102670, 3e)copy SMILEScopy InChI
Affinity DataIC50: 4.70nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174424(US9102670, 1ee)copy SMILEScopy InChI
Affinity DataIC50: 4.80nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174767(US9102670, 1de)copy SMILEScopy InChI
Affinity DataIC50: 4.90nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd

LigandPNGBDBM50177440(4-(3-(1-cyclohexyl-1,4-diazepane-4-carbonyl)-4-flu...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against PARP1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3K12PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd

LigandPNGBDBM50177446(4-(3-(1-(cyclopropylmethyl)-1,4-diazepane-4-carbon...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against PARP1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3K12PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM174291(US9102670, 1f)copy SMILEScopy InChI
Affinity DataIC50: 5nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M35MZUS Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd

LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd

LigandPNGBDBM27565(4-({4-fluoro-3-[(4-propanoylpiperazin-1-yl)carbony...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd

LigandPNGBDBM27562(4-({3-[(4-butylpiperazin-1-yl)carbonyl]-4-fluoroph...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd

LigandPNGBDBM27553(4-({4-fluoro-3-[(4-phenylpiperazin-1-yl)carbonyl]p...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP014TPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd

LigandPNGBDBM50177458(4-(4-fluoro-3-(1-propyl-1,4-diazepane-4-carbonyl)b...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against PARP1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3K12PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd

LigandPNGBDBM50165486(1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)m...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibitory concentration against human poly (ADP-ribose) polymerase 1 (PARP-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3M0BPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd

LigandPNGBDBM50165497(3-[2-Fluoro-5-(4-oxo-3,4-dihydro-phthalazin-1-ylme...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibitory concentration against human poly (ADP-ribose) polymerase 1 (PARP-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3M0BPubMed
Displayed 1 to 50 (of 1049 total ) | Next | Last >>
Jump to: