Compile Data Set for Download or QSAR
Found 303 with Last Name = 'curtis' and Initial = 'nr'
TargetD(4) dopamine receptor(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM85093(CAS_3853 | CHEMBL267014 | CHEMBL555670 | L 745,870...)copy SMILEScopy InChI
Affinity DataKi:  0.430nMAssay Description:Binding affinity towards cloned human Dopamine receptor D4 stably expressed in CHO cells was evaluated using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MW2G6DPubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM85093(CAS_3853 | CHEMBL267014 | CHEMBL555670 | L 745,870...)copy SMILEScopy InChI
Affinity DataKi:  0.430nMAssay Description:Ability to displace [3H]-spiperone from cloned human dopamine D4 receptor stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9HD4PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451786(CHEMBL423244)copy SMILEScopy InChI
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KK9D95PubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50050465(3-[4-(4-Iodo-phenyl)-piperazin-1-ylmethyl]-1H-pyrr...)copy SMILEScopy InChI
Affinity DataKi:  0.510nMAssay Description:Binding affinity towards cloned human Dopamine receptor D4 stably expressed in CHO cells was evaluated using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MW2G6DPubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124914(CHEMBL161180 | N-(3,5-Dichloro-benzyl)-4-trifluoro...)copy SMILEScopy InChI
Affinity DataKi:  0.600nMAssay Description:Displacement of NMDA receptor-specific [3H]-ifenprodil binding to recombinant human NMDA receptor, NR2B subtype expressed in L cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FX78TPPubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139355(2-(6-Phenylpyridin-2-ylthio)-N,N-dimethylethan-ami...)copy SMILEScopy InChI
Affinity DataKi:  0.600nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CJ8CWSPubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451785(CHEMBL159675)copy SMILEScopy InChI
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KK9D95PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124885((E)-N-(2-Methoxy-benzyl)-3-phenyl-acrylamidine | C...)copy SMILEScopy InChI
Affinity DataKi:  0.700nMAssay Description:Displacement of NMDA receptor-specific [3H]-ifenprodil binding to recombinant human NMDA receptor, NR2B subtype expressed in L cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FX78TPPubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139351(2-(6-cyclohexylpyridin-2-ylthio)-N,N-dimethylethan...)copy SMILEScopy InChI
Affinity DataKi:  0.700nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CJ8CWSPubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124885((E)-N-(2-Methoxy-benzyl)-3-phenyl-acrylamidine | C...)copy SMILEScopy InChI
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KK9D95PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451789(CHEMBL159762)copy SMILEScopy InChI
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KK9D95PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451766(CHEMBL159761)copy SMILEScopy InChI
Affinity DataKi:  1nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KK9D95PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124909(CHEMBL159744 | N-(3,5-Dimethyl-benzyl)-4-trifluoro...)copy SMILEScopy InChI
Affinity DataKi:  1.20nMAssay Description:Displacement of NMDA receptor-specific [3H]-ifenprodil binding to recombinant human NMDA receptor, NR2B subtype expressed in L cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FX78TPPubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451778(CHEMBL159416)copy SMILEScopy InChI
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KK9D95PubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139353((2-tert-Butylsulfanyl-ethyl)-dimethyl-amine | CHEM...)copy SMILEScopy InChI
Affinity DataKi:  1.30nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CJ8CWSPubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075360(3-[4-(4-Methoxy-phenyl)-piperazin-1-ylmethyl]-1H-p...)copy SMILEScopy InChI
Affinity DataKi:  1.30nMAssay Description:Ability to displace [3H]-spiperone from cloned human dopamine D4 receptor stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9HD4PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451769(CHEMBL159902)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KK9D95PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451772(CHEMBL159453)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KK9D95PubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:Binding affinity towards cloned human Dopamine receptor D2 stably expressed in CHO cells was evaluated using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MW2G6DPubMedDrugBank
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451784(CHEMBL159790)copy SMILEScopy InChI
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KK9D95PubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50050462(3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-1H-in...)copy SMILEScopy InChI
Affinity DataKi:  1.60nMAssay Description:Binding affinity towards cloned human Dopamine receptor D4 stably expressed in CHO cells was evaluated using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MW2G6DPubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451779(CHEMBL160027)copy SMILEScopy InChI
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KK9D95PubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075362(3-(4-Phenethyl-piperidin-1-ylmethyl)-1H-pyrrolo[2,...)copy SMILEScopy InChI
Affinity DataKi:  1.80nMAssay Description:Ability to displace [3H]-spiperone from cloned human dopamine D4 receptor stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9HD4PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451780(CHEMBL161859)copy SMILEScopy InChI
Affinity DataKi:  1.90nMAssay Description:Selectivity for inhibition of the response to glutamate/glycine in NR1a/NR2A expressing cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KK9D95PubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075357(2-(4-Phenethyl-piperidin-1-ylmethyl)-1H-pyrrolo[2,...)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Ability to displace [3H]-spiperone from cloned human dopamine D4 receptor stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9HD4PubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Binding affinity towards cloned human Dopamine receptor D3 stably expressed in CHO cells was evaluated using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MW2G6DPubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)copy SMILEScopy InChI
Affinity DataKi:  2.30nMAssay Description:Binding affinity towards cloned human Dopamine receptor D4 stably expressed in CHO cells was evaluated using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MW2G6DPubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50050467(1-((1H-indol-3-yl)methyl)-4-(4-chlorophenyl)piperi...)copy SMILEScopy InChI
Affinity DataKi:  2.40nMAssay Description:Binding affinity towards cloned human Dopamine receptor D2 stably expressed in CHO cells was evaluated using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MW2G6DPubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451764(CHEMBL159425)copy SMILEScopy InChI
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KK9D95PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451770(CHEMBL350614)copy SMILEScopy InChI
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KK9D95PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124923(CHEMBL162080 | N-(3,5-Dimethyl-benzyl)-4-trifluoro...)copy SMILEScopy InChI
Affinity DataKi:  3.90nMAssay Description:Displacement of NMDA receptor-specific [3H]-ifenprodil binding to recombinant human NMDA receptor, NR2B subtype expressed in L cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FX78TPPubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139361(2-(6-Bromopyridin-2-ylthio)-N,N-dimethylethanamine...)copy SMILEScopy InChI
Affinity DataKi:  4.10nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CJ8CWSPubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451783(CHEMBL348727)copy SMILEScopy InChI
Affinity DataKi:  5.70nMAssay Description:Inhibition of the response to glutamate/glycine in NR1a/NR2B expressing cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KK9D95PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124908(CHEMBL159560 | N-(2-Methoxy-benzyl)-4-trifluoromet...)copy SMILEScopy InChI
Affinity DataKi:  5.70nMAssay Description:Displacement of NMDA receptor-specific [3H]-ifenprodil binding to recombinant human NMDA receptor, NR2B subtype expressed in L cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FX78TPPubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50450987(CHEMBL2112913)copy SMILEScopy InChI
Affinity DataKi:  6.5nMAssay Description:Ability to displace [3H]-spiperone from cloned human dopamine D4 receptor stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9HD4PubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075363(2-(1H-Pyrrolo[2,3-b]pyridin-3-ylmethyl)-1,2,3,4-te...)copy SMILEScopy InChI
Affinity DataKi:  7nMAssay Description:Ability to displace [3H]-spiperone from cloned human dopamine D4 receptor stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9HD4PubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139354(1-[6-(2-Dimethylamino-ethylsulfanyl)-pyridin-2-yl]...)copy SMILEScopy InChI
Affinity DataKi:  7.20nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CJ8CWSPubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451777(CHEMBL159306)copy SMILEScopy InChI
Affinity DataKi:  7.30nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KK9D95PubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50050464(3-(4-Phenyl-piperazin-1-ylmethyl)-1H-indole | CHEM...)copy SMILEScopy InChI
Affinity DataKi:  8nMAssay Description:Binding affinity towards cloned human Dopamine receptor D4 stably expressed in CHO cells was evaluated using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MW2G6DPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139351(2-(6-cyclohexylpyridin-2-ylthio)-N,N-dimethylethan...)copy SMILEScopy InChI
Affinity DataKi:  8.70nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1A receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in HeL...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CJ8CWSPubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124892((E)-N-Benzyl-3-phenyl-acrylamidine | CHEMBL158874)copy SMILEScopy InChI
Affinity DataKi:  9nMAssay Description:Displacement of NMDA receptor-specific [3H]-ifenprodil binding to recombinant human NMDA receptor, NR2B subtype expressed in L cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FX78TPPubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124892((E)-N-Benzyl-3-phenyl-acrylamidine | CHEMBL158874)copy SMILEScopy InChI
Affinity DataKi:  9nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KK9D95PubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50450988(CHEMBL2112912)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:Ability to displace [3H]-spiperone from cloned human dopamine D3 receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9HD4PubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:Binding affinity towards cloned human Dopamine receptor D4 stably expressed in CHO cells was evaluated using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MW2G6DPubMedDrugBank
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50080029(4-((1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-...)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50032651(1-((1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-y...)copy SMILEScopy InChI
Affinity DataKi:  11nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KK9D95PubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075359(2-{2-[4-(4-Chloro-phenyl)-piperazin-1-yl]-ethyl}-1...)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Ability to displace [3H]-spiperone from cloned human dopamine D4 receptor stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NV9HD4PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124918(3,4-Dichloro-N-(2-trifluoromethoxy-benzyl)-benzami...)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Displacement of NMDA receptor-specific [3H]-ifenprodil binding to recombinant human NMDA receptor, NR2B subtype expressed in L cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FX78TPPubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451782(CHEMBL159894)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KK9D95PubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139357(CHEMBL345803 | Dimethyl-[2-(4-phenyl-thiazol-2-yls...)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CJ8CWSPubMed
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