Compile Data Set for Download or QSAR
Found 102 with Last Name = 'boissin' and Initial = 'p'
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071369(CHEMBL3410220)copy SMILEScopy InChI
Affinity DataKi:  17nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071328(CHEMBL3410213)copy SMILEScopy InChI
Affinity DataKi:  18nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071375(CHEMBL3410223 | US10618900, No. CTEP)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071372(CHEMBL1946770)copy SMILEScopy InChI
Affinity DataKi:  22nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071333(CHEMBL3410215)copy SMILEScopy InChI
Affinity DataKi:  28nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071332(CHEMBL3410214)copy SMILEScopy InChI
Affinity DataKi:  29nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071371(CHEMBL3410221)copy SMILEScopy InChI
Affinity DataKi:  32nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071376(CHEMBL3410224)copy SMILEScopy InChI
Affinity DataKi:  33nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071374(Basimglurant | RG-7090 | RO-4917523)copy SMILEScopy InChI
Affinity DataKi:  36nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071324(CHEMBL3410207)copy SMILEScopy InChI
Affinity DataKi:  69nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071322(CHEMBL3410209)copy SMILEScopy InChI
Affinity DataKi:  72nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071335(CHEMBL3410217)copy SMILEScopy InChI
Affinity DataKi:  83nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071334(CHEMBL3410216)copy SMILEScopy InChI
Affinity DataKi:  90nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071326(CHEMBL3410211)copy SMILEScopy InChI
Affinity DataKi:  213nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071367(CHEMBL3410218)copy SMILEScopy InChI
Affinity DataKi:  252nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071327(CHEMBL3410212)copy SMILEScopy InChI
Affinity DataKi:  255nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071377(CHEMBL3407528)copy SMILEScopy InChI
Affinity DataKi:  368nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071378(CHEMBL3410225)copy SMILEScopy InChI
Affinity DataKi:  559nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071368(CHEMBL3410219)copy SMILEScopy InChI
Affinity DataKi:  567nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071373(CHEMBL3410222)copy SMILEScopy InChI
Affinity DataKi:  1.44E+3nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071323(CHEMBL3410208)copy SMILEScopy InChI
Affinity DataKi:  1.77E+3nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071325(CHEMBL3410210)copy SMILEScopy InChI
Affinity DataKi:  2.84E+3nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Laboratoires Glaxo

LigandPNGBDBM2685(3-(1H-indol-3-yl)-4-{1-[2-(piperidin-2-yl)ethyl]-1...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:The activity of PKC, activated by phosphatidylserine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich hi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FF3QJ4PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071374(Basimglurant | RG-7090 | RO-4917523)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071328(CHEMBL3410213)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Laboratoires Glaxo

LigandPNGBDBM2683(2-[1-(3-dimethylaminopropyl)-indol-3-yl]-3-(indol-...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The activity of PKC, activated by phosphatidylserine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich hi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FF3QJ4PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071375(CHEMBL3410223 | US10618900, No. CTEP)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071332(CHEMBL3410214)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071369(CHEMBL3410220)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Laboratoires Glaxo

LigandPNGBDBM2694(3-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:The activity of PKC, activated by phosphatidylserine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich hi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FF3QJ4PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071333(CHEMBL3410215)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071376(CHEMBL3410224)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071322(CHEMBL3410209)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Laboratoires Glaxo

LigandPNGBDBM2691(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:The activity of PKC, activated by phosphatidylserine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich hi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FF3QJ4PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071372(CHEMBL1946770)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071334(CHEMBL3410216)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Laboratoires Glaxo

LigandPNGBDBM2681(3-{1-[3-(dimethylamino)propyl]-1H-indol-3-yl}-4-(1...)copy SMILEScopy InChI
Affinity DataIC50: 40nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FF3QJ4PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Laboratoires Glaxo

LigandPNGBDBM2692(3-(1H-indol-3-yl)-4-{1-[(1-methylpiperidin-3-yl)me...)copy SMILEScopy InChI
Affinity DataIC50: 45nMAssay Description:The activity of PKC, activated by phosphatidylserine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich hi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FF3QJ4PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Laboratoires Glaxo

LigandPNGBDBM2686(3-(1H-indol-3-yl)-4-{1-[3-(piperazin-1-yl)propyl]-...)copy SMILEScopy InChI
Affinity DataIC50: 52nMAssay Description:The activity of PKC, activated by phosphatidylserine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich hi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FF3QJ4PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071335(CHEMBL3410217)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Laboratoires Glaxo

LigandPNGBDBM2693(3-(1H-indol-3-yl)-4-{1-[3-(morpholin-4-yl)propyl]-...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:The activity of PKC, activated by phosphatidylserine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich hi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FF3QJ4PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Laboratoires Glaxo

LigandPNGBDBM2690(3-(1-{2-[(dimethylamino)methyl]propyl}-1H-indol-3-...)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:The activity of PKC, activated by phosphatidylserine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich hi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FF3QJ4PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071371(CHEMBL3410221)copy SMILEScopy InChI
Affinity DataIC50: 97nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Laboratoires Glaxo

LigandPNGBDBM2682(3-{1-[3-(dimethylamino)propyl]-1H-indol-3-yl}-4-[1...)copy SMILEScopy InChI
Affinity DataIC50: 100nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FF3QJ4PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Laboratoires Glaxo

LigandPNGBDBM2583(3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(...)copy SMILEScopy InChI
Affinity DataIC50: 100nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FF3QJ4PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071367(CHEMBL3410218)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071326(CHEMBL3410211)copy SMILEScopy InChI
Affinity DataIC50: 124nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071368(CHEMBL3410219)copy SMILEScopy InChI
Affinity DataIC50: 141nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50071324(CHEMBL3410207)copy SMILEScopy InChI
Affinity DataIC50: 161nMAssay Description:Negative allosteric modulation of mGlu5 (unknown origin) expressed in HEK293 cells assessed as inhibition of L-AP4-induced calcium mobilization incub...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J96825PubMed
TargetPhosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform(Oryctolagus cuniculus (rabbit))
Laboratoires Glaxo

LigandPNGBDBM2691(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:The activity of PK is measured by its ability to transfer from [gamma-32P]ATP to phosphorylase b.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FF3QJ4PubMed
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