Affinity DataKi: 2.43E+3nMAssay Description:Binding affinity to adenosine A3 receptor (unknown origin) by agonist displacement assayMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Schering-Plough Corporation
Curated by ChEMBL
Schering-Plough Corporation
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Compound tested in vitro for inhibition of Angiotensin I converting enzymeMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Schering-Plough Corporation
Curated by ChEMBL
Schering-Plough Corporation
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Compound tested in vitro for inhibition of Angiotensin I converting enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Compound tested in vivo for inhibition of Angiotensin I converting enzyme in ratMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Schering-Plough Corporation
Curated by ChEMBL
Schering-Plough Corporation
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Compound tested in vitro for inhibition of Angiotensin I converting enzymeMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged DYRK1A (1 to 763 residues) expressed in Sf21 cells using Ulight-glycogen synthase as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human DYRK1A (129 to 509 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Affinity DataIC50: 6.20nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged DYRK1A (1 to 763 residues) expressed in Sf21 cells using Ulight-glycogen synthase as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged DYRK1A (1 to 763 residues) expressed in Sf21 cells using Ulight-glycogen synthase as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged DYRK1A (1 to 763 residues) expressed in Sf21 cells using Ulight-glycogen synthase as substrate ...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Schering-Plough Corporation
Curated by ChEMBL
Schering-Plough Corporation
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Compound tested in vitro for inhibition of Angiotensin I converting enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged DYRK1A (1 to 763 residues) expressed in Sf21 cells using Ulight-glycogen synthase as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human GSK3beta (1 to 433 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged DYRK1A (1 to 763 residues) expressed in Sf21 cells using Ulight-glycogen synthase as substrate ...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged DYRK1A (1 to 763 residues) expressed in Sf21 cells using Ulight-glycogen synthase as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged DYRK1A (1 to 763 residues) expressed in Sf21 cells using Ulight-glycogen synthase as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant human GSK3beta (1 to 433 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-stimulated cAMP production preincubated for 30 mins follo...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged DYRK1A (1 to 763 residues) expressed in Sf21 cells using Ulight-glycogen synthase as substrate ...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged DYRK1A (1 to 763 residues) expressed in Sf21 cells using Ulight-glycogen synthase as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-stimulated cAMP production preincubated for 30 mins follo...More data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-stimulated cAMP production preincubated for 30 mins follo...More data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-stimulated cAMP production preincubated for 30 mins follo...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair