Compile Data Set for Download or QSAR
Found 315 with Last Name = 'worland' and Initial = 'p'
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50093070(CHEMBL3586561)copy SMILES
Affinity DataIC50: 3nMAssay Description:Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2QRVPubMed
TargetFKBP12A/mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50093070(CHEMBL3586561)copy SMILES
Affinity DataIC50: 4nMAssay Description:Inhibition of mTORC1 in human PC3 cells assessed as inhibition of p70S6K phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2QRVPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50092785(CHEMBL3586383)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q208672FPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50092784(CHEMBL3586382)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q208672FPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50092786(CHEMBL3586384)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q208672FPubMed
TargetFKBP12A/mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50093075(CHEMBL3586566)copy SMILES
Affinity DataIC50: 6nMAssay Description:Inhibition of mTORC1 in human PC3 cells assessed as inhibition of p70S6K phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2QRVPubMed
TargetFKBP12A/mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50092782(CHEMBL3586387)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of mTORC1 in human PC3 cells assessed as inhibition of p70S6K phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2QRVPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50093075(CHEMBL3586566)copy SMILES
Affinity DataIC50: 8nMAssay Description:Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2QRVPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50431521(CHEMBL2348864)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q208672FPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM6027(N-(4-{[3-Ethyl-4-oxo-1-(2,4,6-trichlorophenyl)-4,5...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J692NPubMed
TargetFKBP12A/mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50093077(CHEMBL3586568)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of mTORC1 in human PC3 cells assessed as inhibition of p70S6K phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2QRVPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50092783(CHEMBL3586404)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q208672FPubMed
TargetFKBP12A/mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50093080(CHEMBL3586571)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of mTORC1 in human PC3 cells assessed as inhibition of p70S6K phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2QRVPubMed
TargetFKBP12A/mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50093076(CHEMBL3586567)copy SMILES
Affinity DataIC50: 12nMAssay Description:Inhibition of mTORC1 in human PC3 cells assessed as inhibition of p70S6K phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2QRVPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50093069(CHEMBL3586560)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2QRVPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50092769(CHEMBL3586397)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q208672FPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM6029(2-Amino-N-(4-{[3-ethyl-4-oxo-1-(2,4,6-trichlorophe...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J692NPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM6025(3-Ethyl-6-(3-hydroxybenzyl)-1-(2,4,6-trichlorophen...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J692NPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50092782(CHEMBL3586387)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2QRVPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50092782(CHEMBL3586387)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q208672FPubMed
TargetFKBP12A/mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50093069(CHEMBL3586560)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of mTORC1 in human PC3 cells assessed as inhibition of S6 phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2QRVPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50093074(CHEMBL3586565)copy SMILES
Affinity DataIC50: 15nMAssay Description:Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2QRVPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM6011(6-(4-Aminobenzyl)-3-ethyl-1-(2,4,6-trichlorophenyl...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J692NPubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50093082(CHEMBL3586573)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of human DNA PKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2QRVPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM6012(3-Ethyl-6-(4-methoxybenzyl)-1-(2,4,6-trichlorophen...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J692NPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM6028(2-(tert-Butoxycarbonylamino)-N-(4-{[3-ethyl-4-oxo-...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J692NPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM6013(3-Ethyl-6-(4-hydroxybenzyl)-1-(2,4,6-trichlorophen...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J692NPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM6009(3-Ethyl-6-(pyrid-3-ylmethyl)-1-(2,4,6-trichlorophe...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J692NPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50092780(CHEMBL3586385)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q208672FPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM6030(2-(Dimethylamino)-N-(4-{[3-ethyl-4-oxo-1-(2,4,6-tr...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J692NPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50093080(CHEMBL3586571)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2QRVPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50093076(CHEMBL3586567)copy SMILES
Affinity DataIC50: 19nMAssay Description:Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2QRVPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM6023(3-Ethyl-6-(3-hydroxy-4-methoxybenzyl)-1-(2,4,6-tri...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J692NPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM6004(6-(3-Amino-2-methylbenzyl)-3-ethyl-1-(2,4,6-trichl...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J692NPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM6021(6-(3,4-Dihydroxybenzyl)-3-ethyl-1-(2,4,6-trichloro...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
TargetFKBP12A/mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50093074(CHEMBL3586565)copy SMILES
Affinity DataIC50: 20nMAssay Description:Inhibition of mTORC1 in human PC3 cells assessed as inhibition of S6 phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2QRVPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50093082(CHEMBL3586573)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2QRVPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM6022(6-(3,5-Dihydroxybenzyl)-3-ethyl-1-(2,4,6-trichloro...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J692NPubMed
TargetFKBP12A/mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50093082(CHEMBL3586573)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of mTORC1 in human PC3 cells assessed as inhibition of S6 phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2QRVPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM6024(3-Ethyl-6-(3-hydroxy-4-methylbenzyl)-1-(2,4,6-tric...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J692NPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM6015(6-(4-(N,N-Dimethylamino)benzyl)-3-ethyl-1-(2,4,6-t...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J692NPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM6023(3-Ethyl-6-(3-hydroxy-4-methoxybenzyl)-1-(2,4,6-tri...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J692NPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5998(6-Benzyl-3-ethyl-1-(2,4,6-trichlorophenyl)-4,5-dih...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J692NPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50092793(CHEMBL3586380)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q208672FPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50093077(CHEMBL3586568)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2QRVPubMed
TargetFKBP12A/mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50093071(CHEMBL3586562)copy SMILES
Affinity DataIC50: 27nMAssay Description:Inhibition of mTORC1 in human PC3 cells assessed as inhibition of p70S6K phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2QRVPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM6018(3-Ethyl-6-(4-hydroxy-3-methylbenzyl)-1-(2,4,6-tric...)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J692NPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM6002(3-Ethyl-6-(2-(hydroxymethyl)benzyl)-1-(2,4,6-trich...)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J692NPubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50092783(CHEMBL3586404)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of cFMS (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q208672FPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50093078(CHEMBL3586569)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2QRVPubMed
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