Compile Data Set for Download or QSAR
Found 400 with Last Name = 'bethel' and Initial = 'pa'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)copy SMILEScopy InChI
Affinity DataIC50: 0.570nMAssay Description:Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)copy SMILEScopy InChI
Affinity DataIC50: 0.630nMAssay Description:Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetProcathepsin L(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414644(CHEMBL555122)copy SMILEScopy InChI
Affinity DataIC50: 1.26nMAssay Description:Inhibition of cathepsin L assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetProcathepsin L(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414643(CHEMBL557455)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of cathepsin L assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50029670(CHEMBL2426277 | US10227342, Example 26)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2Z4CPubMed
TargetCathepsin L2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414641(CHEMBL554065)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetCathepsin S(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414636(CHEMBL559880)copy SMILEScopy InChI
Affinity DataIC50: 2.51nMAssay Description:Inhibition of cathepsin S assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetCathepsin L2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414640(CHEMBL562844)copy SMILEScopy InChI
Affinity DataIC50: 3.16nMAssay Description:Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetProcathepsin L(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414641(CHEMBL554065)copy SMILEScopy InChI
Affinity DataIC50: 3.98nMAssay Description:Inhibition of cathepsin L assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50029667(CHEMBL2426288)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2Z4CPubMed
TargetProcathepsin L(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414638(CHEMBL549378)copy SMILEScopy InChI
Affinity DataIC50: 5.01nMAssay Description:Inhibition of cathepsin L assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetProcathepsin L(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414639(CHEMBL550872)copy SMILEScopy InChI
Affinity DataIC50: 5.01nMAssay Description:Inhibition of cathepsin L assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50493289(CHEMBL2426278)copy SMILEScopy InChI
Affinity DataIC50: 5.60nMAssay Description:Inhibition of EGFR L858R/T970M double mutant phosphorylation in human NCI-H1975 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN98KQPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)copy SMILEScopy InChI
Affinity DataIC50: 5.90nMAssay Description:Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50029685(CHEMBL3353404 | US10227342, Example 52)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2Z4CPubMed
TargetCathepsin L2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414638(CHEMBL549378)copy SMILEScopy InChI
Affinity DataIC50: 6.31nMAssay Description:Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetCathepsin L2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414639(CHEMBL550872)copy SMILEScopy InChI
Affinity DataIC50: 6.31nMAssay Description:Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetProcathepsin L(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414642(CHEMBL549791)copy SMILEScopy InChI
Affinity DataIC50: 6.31nMAssay Description:Inhibition of cathepsin L assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50029684(CHEMBL3353403)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2Z4CPubMed
TargetCathepsin L2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414642(CHEMBL549791)copy SMILEScopy InChI
Affinity DataIC50: 7.94nMAssay Description:Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetCathepsin S(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414633(CHEMBL556436)copy SMILEScopy InChI
Affinity DataIC50: 7.94nMAssay Description:Inhibition of cathepsin S assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)copy SMILEScopy InChI
Affinity DataIC50: 8.70nMAssay Description:Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetInsulin receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50029685(CHEMBL3353404 | US10227342, Example 52)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of INSR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2Z4CPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of wild type EGFR phosphorylation in human LoVo cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of wild type EGFR phosphorylation in human LoVo cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetProcathepsin L(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM31993(Dipeptidyl nitrile inhibitor, 26)copy SMILEScopy InChI
Affinity DataIC50: 12.6nMAssay Description:Inhibition of cathepsin L assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetProcathepsin L(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM31992(Dipeptidyl nitrile inhibitor, 25)copy SMILEScopy InChI
Affinity DataIC50: 12.6nMAssay Description:Inhibition of cathepsin L assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31993(Dipeptidyl nitrile inhibitor, 26)copy SMILEScopy InChI
Affinity DataIC50: 13nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31992(Dipeptidyl nitrile inhibitor, 25)copy SMILEScopy InChI
Affinity DataIC50: 13nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50029669(CHEMBL2426279)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2Z4CPubMed
TargetProcathepsin L(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414629(CHEMBL563471)copy SMILEScopy InChI
Affinity DataIC50: 15.8nMAssay Description:Inhibition of cathepsin L assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetProcathepsin L(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414637(CHEMBL562915)copy SMILEScopy InChI
Affinity DataIC50: 15.8nMAssay Description:Inhibition of cathepsin L assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetCathepsin S(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414638(CHEMBL549378)copy SMILEScopy InChI
Affinity DataIC50: 15.8nMAssay Description:Inhibition of cathepsin S assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50029669(CHEMBL2426279)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN98KQPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50029670(CHEMBL2426277 | US10227342, Example 26)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of EGFR L858R/T970M double mutant phosphorylation in human NCI-H1975 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2Z4CPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50029670(CHEMBL2426277 | US10227342, Example 26)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of EGFR L858R/T970M double mutant phosphorylation in human NCI-H1975 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN98KQPubMed
TargetCathepsin L2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414637(CHEMBL562915)copy SMILEScopy InChI
Affinity DataIC50: 19.9nMAssay Description:Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetCathepsin S(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414635(CHEMBL564626)copy SMILEScopy InChI
Affinity DataIC50: 19.9nMAssay Description:Inhibition of cathepsin S assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31984(Dipeptidyl nitrile inhibitor, 17)copy SMILEScopy InChI
Affinity DataIC50: 20nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetInsulin receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50029684(CHEMBL3353403)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of INSR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2Z4CPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50493288(CHEMBL2426282)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of EGFR L858R/T970M double mutant phosphorylation in human NCI-H1975 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN98KQPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of EGFR L858R/T970M double mutant phosphorylation in human NCI-H1975 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of EGFR L858R/T970M double mutant phosphorylation in human NCI-H1975 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50493289(CHEMBL2426278)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN98KQPubMed
TargetCathepsin L2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414636(CHEMBL559880)copy SMILEScopy InChI
Affinity DataIC50: 25.1nMAssay Description:Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50029686(CHEMBL3353405 | US10227342, Example 25)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2Z4CPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50493288(CHEMBL2426282)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN98KQPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50493291(CHEMBL2426286)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:Inhibition of EGFR L858R/T970M double mutant phosphorylation in human NCI-H1975 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN98KQPubMed
TargetInsulin receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50029686(CHEMBL3353405 | US10227342, Example 25)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of INSR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2Z4CPubMed
TargetCathepsin L2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414643(CHEMBL557455)copy SMILEScopy InChI
Affinity DataIC50: 39.8nMAssay Description:Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
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