Compile Data Set for Download or QSAR
Found 110 with Last Name = 'ehmer' and Initial = 'pb'
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type 2 from human BPH tissue at 210 nM of testosteroneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMedDrugBank
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50093602(17-(1H-Imidazol-4-yl)-10,13-dimethyl-2,3,4,7,8,9,1...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of human Cytochrome P450 17More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type I in human DU-145 cell assay at 5 nM of androstenedioneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of Human steroid 5-alpha-reductase type II expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMedDrugBank
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50409034(CHEMBL2112731)copy SMILEScopy InChI
Affinity DataIC50: 77nMAssay Description:Evaluated for the inhibitory activity towards Cytochrome P450 17 human enzyme using testicular microsome at 25 uM of substrate (progesterone)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50093600(17-(1-Hydroxyimino-ethyl)-10,13-dimethyl-1,2,6,7,8...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Evaluated for the inhibitory activity towards Cytochrome P450 17 human enzyme using testicular microsome at 25 uM of substrate (progesterone)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM8935(5-[(6-methoxy-1-methyl-3,4-dihydronaphthalen-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 110nMpH: 7.4 T: 2°CAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9N9TPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM8951(4-Imidazol-1-ylmethyl-biphenyl-3,4-diol | 4-[4-(1H...)copy SMILEScopy InChI
Affinity DataIC50: 120nMpH: 7.4 T: 2°CAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9N9TPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50409033(CHEMBL2112735)copy SMILEScopy InChI
Affinity DataIC50: 140nMAssay Description:Evaluated for the inhibitory activity towards Cytochrome P450 17 rat enzyme using testicular microsome at 25 uM of substrate (progesterone)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50409032(CHEMBL2112737)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Evaluated for the inhibitory activity towards Cytochrome P450 17 human enzyme using testicular microsome at 25 uM of substrate (progesterone)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50409033(CHEMBL2112735)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Evaluated for the inhibitory activity towards Cytochrome P450 17 human enzyme using testicular microsome at 25 uM of substrate (progesterone)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50093602(17-(1H-Imidazol-4-yl)-10,13-dimethyl-2,3,4,7,8,9,1...)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Inhibition of rat Cytochrome P450 17More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50093591(17-(1-Hydroxyimino-ethyl)-10,13-dimethyl-1,2,6,7,8...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Evaluated for the inhibitory activity towards Cytochrome P450 17 human enzyme using testicular microsome at 25 uM of substrate (progesterone)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50409030(CHEMBL2112747)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Evaluated for the inhibitory activity towards Cytochrome P450 17 human enzyme using testicular microsome at 25 uM of substrate (progesterone)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50409034(CHEMBL2112731)copy SMILEScopy InChI
Affinity DataIC50: 230nMAssay Description:Inhibition of Human P450 17 and NADPH-P450 reductase co-expressed in Escherichia coli with 25 uM progesteroneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50093603((3-Hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,...)copy SMILEScopy InChI
Affinity DataIC50: 270nMAssay Description:Evaluated for the inhibitory activity towards Cytochrome P450 17 human enzyme using testicular microsome at 25 uM of substrate (progesterone)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50093590((10,13-Dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,1...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type 2 from human BPH tissue at 210 nM of testosteroneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50093590((10,13-Dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,1...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Evaluated for the inhibitory activity towards Cytochrome P450 17 rat enzyme using testicular microsome at 25 uM of substrate (progesterone)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50409030(CHEMBL2112747)copy SMILEScopy InChI
Affinity DataIC50: 420nMAssay Description:Inhibition of Human P450 17 and NADPH-P450 reductase co-expressed in Escherichia coli with 25 uM progesteroneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50093598(17-(2-Hydroxyimino-propyl)-10,13-dimethyl-1,7,8,9,...)copy SMILEScopy InChI
Affinity DataIC50: 430nMAssay Description:Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type 2 from human BPH tissue at 210 nM of testosteroneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50409033(CHEMBL2112735)copy SMILEScopy InChI
Affinity DataIC50: 430nMAssay Description:Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type 2 from human BPH tissue at 210 nM of testosteroneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50093592(17-(2-Hydroxyimino-propyl)-10,13-dimethyl-1,2,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 470nMAssay Description:Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type 2 from human BPH tissue at 210 nM of testosteroneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM8946(3,4-Dihydro-2-(5-imidazolyl)-6,7-dimethoxy-1-methy...)copy SMILEScopy InChI
Affinity DataIC50: 490nMpH: 7.4 T: 2°CAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9N9TPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50409032(CHEMBL2112737)copy SMILEScopy InChI
Affinity DataIC50: 520nMAssay Description:Inhibition of Human P450 17 and NADPH-P450 reductase co-expressed in Escherichia coli with 25 uM progesteroneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50093590((10,13-Dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,1...)copy SMILEScopy InChI
Affinity DataIC50: 520nMAssay Description:Evaluated for the inhibitory activity towards Cytochrome P450 17 human enzyme using testicular microsome at 25 uM of substrate (progesterone)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50409034(CHEMBL2112731)copy SMILEScopy InChI
Affinity DataIC50: 520nMAssay Description:Evaluated for the inhibitory activity towards Cytochrome P450 17 rat enzyme using testicular microsome at 25 uM of substrate (progesterone)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)copy SMILEScopy InChI
Affinity DataIC50: 540nMAssay Description:Inhibition of Human steroid 5-alpha-reductase type I expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50093594(17-(1-Hydroxyimino-ethyl)-10,13-dimethyl-1,2,6,7,8...)copy SMILEScopy InChI
Affinity DataIC50: 580nMAssay Description:Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type 2 from human BPH tissue at 210 nM of testosteroneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50093594(17-(1-Hydroxyimino-ethyl)-10,13-dimethyl-1,2,6,7,8...)copy SMILEScopy InChI
Affinity DataIC50: 580nMAssay Description:Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type 2 from human BPH tissue at 210 nM of testosteroneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)copy SMILEScopy InChI
Affinity DataIC50: 740nMAssay Description:Evaluated for the inhibitory activity towards Cytochrome P450 17 human enzyme using testicular microsome at 25 uM of substrate (progesterone)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50093598(17-(2-Hydroxyimino-propyl)-10,13-dimethyl-1,7,8,9,...)copy SMILEScopy InChI
Affinity DataIC50: 860nMAssay Description:Inhibition of Human steroid 5-alpha-reductase type II expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50093590((10,13-Dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,1...)copy SMILEScopy InChI
Affinity DataIC50: 890nMAssay Description:Inhibition of Human steroid 5-alpha-reductase type II expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50093592(17-(2-Hydroxyimino-propyl)-10,13-dimethyl-1,2,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 900nMAssay Description:Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type I in human DU-145 cell assay at 5 nM of androstenedioneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50093598(17-(2-Hydroxyimino-propyl)-10,13-dimethyl-1,7,8,9,...)copy SMILEScopy InChI
Affinity DataIC50: 900nMAssay Description:Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type I in human DU-145 cell assay at 5 nM of androstenedioneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM8937(7-(1H-imidazol-5-ylmethyl)-3-methoxy-8-methyl-5,6-...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+3nMpH: 7.4 T: 2°CAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9N9TPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50093596(1-(3-Hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,1...)copy SMILEScopy InChI
Affinity DataIC50: 1.18E+3nMAssay Description:Evaluated for the inhibitory activity towards Cytochrome P450 17 human enzyme using testicular microsome at 25 uM of substrate (progesterone)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
TargetAromatase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8953(4-Imidazol-1-ylmethyl-biphenyl-3,4,5-triol | 5-[4-...)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H]androstenedione during aromatization. After incubation, the rea...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9N9TPubMed
TargetAromatase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8933((2E)-2-(1H-imidazol-5-ylmethylidene)-6-methoxy-1,2...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H]androstenedione during aromatization. After incubation, the rea...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9N9TPubMed
TargetAromatase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8935(5-[(6-methoxy-1-methyl-3,4-dihydronaphthalen-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+3nMAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H]androstenedione during aromatization. After incubation, the rea...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9N9TPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50093594(17-(1-Hydroxyimino-ethyl)-10,13-dimethyl-1,2,6,7,8...)copy SMILEScopy InChI
Affinity DataIC50: 1.63E+3nMAssay Description:Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type I in human DU-145 cell assay at 5 nM of androstenedioneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50409031(CHEMBL2112746)copy SMILEScopy InChI
Affinity DataIC50: 1.65E+3nMAssay Description:Inhibition of Cytochrome P450 17 of human testicular microsomes at 25 uM progesteroneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
TargetAromatase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8937(7-(1H-imidazol-5-ylmethyl)-3-methoxy-8-methyl-5,6-...)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+3nMAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H]androstenedione during aromatization. After incubation, the rea...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9N9TPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50093594(17-(1-Hydroxyimino-ethyl)-10,13-dimethyl-1,2,6,7,8...)copy SMILEScopy InChI
Affinity DataIC50: 1.77E+3nMAssay Description:Inhibition of Human steroid 5-alpha-reductase type I expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
TargetAromatase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8951(4-Imidazol-1-ylmethyl-biphenyl-3,4-diol | 4-[4-(1H...)copy SMILEScopy InChI
Affinity DataIC50: 1.80E+3nMAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H]androstenedione during aromatization. After incubation, the rea...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9N9TPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50093590((10,13-Dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,1...)copy SMILEScopy InChI
Affinity DataIC50: 1.95E+3nMAssay Description:Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type I in human DU-145 cell assay at 5 nM of androstenedioneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
TargetAromatase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8941((2E)-6-hydroxy-2-(1H-imidazol-5-ylmethylidene)-1,2...)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+3nMAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H]androstenedione during aromatization. After incubation, the rea...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9N9TPubMed
TargetAromatase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8942((2E)-2-(1H-imidazol-5-ylmethylidene)-6,7-dimethoxy...)copy SMILEScopy InChI
Affinity DataIC50: 2.20E+3nMAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H]androstenedione during aromatization. After incubation, the rea...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9N9TPubMed
TargetAromatase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8936(6-(1H-imidazol-5-ylmethyl)-5-methyl-7,8-dihydronap...)copy SMILEScopy InChI
Affinity DataIC50: 2.30E+3nMAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H]androstenedione during aromatization. After incubation, the rea...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9N9TPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50093590((10,13-Dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,1...)copy SMILEScopy InChI
Affinity DataIC50: 2.44E+3nMAssay Description:Inhibition of Human steroid 5-alpha-reductase type I expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of the Saarland

Curated by ChEMBL
LigandPNGBDBM50093605(1-(3-Hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,1...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Evaluated for the inhibitory activity towards Cytochrome P450 17 human enzyme using testicular microsome at 25 uM of substrate (progesterone)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1SSVPubMed
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